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Molecular Epidemiology Of Salmonella Enterica Subspecies Enterica Serovar Typhi Isolates From Kelantan Using Random Amplified Polymorphic Dna And Single Nucleotide Polymorphism

Typhoid fever is an acute systemic infection of humans caused by Salmonella enterica subspecies enterica serovar Typhi (S. Typhi). Typhoid fever is endemic in Kelantan, a North-eastern state in Peninsular Malaysia. In spite of extensive intervention by the state‘s Public Health Department, outbreaks...

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Main Author: Ja’afar, Ja’afar Nuhu
Format: Thesis
Language:English
Published: 2014
Subjects:
R5-920 Medicine (General)
Online Access:http://eprints.usm.my/46114/1/Ja%E2%80%99afar%20Nuhu%20Ja%E2%80%99afar24.pdf
http://eprints.usm.my/46114/
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spelling my.usm.eprints.46114 http://eprints.usm.my/46114/ Molecular Epidemiology Of Salmonella Enterica Subspecies Enterica Serovar Typhi Isolates From Kelantan Using Random Amplified Polymorphic Dna And Single Nucleotide Polymorphism Ja’afar, Ja’afar Nuhu R5-920 Medicine (General) Typhoid fever is an acute systemic infection of humans caused by Salmonella enterica subspecies enterica serovar Typhi (S. Typhi). Typhoid fever is endemic in Kelantan, a North-eastern state in Peninsular Malaysia. In spite of extensive intervention by the state‘s Public Health Department, outbreaks of typhoid fever continue to occur with the emergence of multi-drug resistant strains. An important strategy to eradicate this persistent disease is to identify the sources and distribution of infection; and for this, a reliable S. Typhi fingerprinting method is needed. Confirmation of the bacteria by phenotypic techniques is difficult due to the vast number of serovars (>1,500) within the subspecies enterica. Current molecular typing methods offer very high discriminatory resolutions; however, the majority are limited in identifying phylogenetic relationships, evolutionary trends or genotypic characteristics. Thus, the main objective of this study was to investigate the effect of nucleotide sequence variations in S. Typhi in relation to its phylogenetic diversity, and to identify possible epidemiological markers for easy identification and confirmation of this pathogen. Two methods were used in this study. 2014-02 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/46114/1/Ja%E2%80%99afar%20Nuhu%20Ja%E2%80%99afar24.pdf Ja’afar, Ja’afar Nuhu (2014) Molecular Epidemiology Of Salmonella Enterica Subspecies Enterica Serovar Typhi Isolates From Kelantan Using Random Amplified Polymorphic Dna And Single Nucleotide Polymorphism. PhD thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic R5-920 Medicine (General)
spellingShingle R5-920 Medicine (General)
Ja’afar, Ja’afar Nuhu
Molecular Epidemiology Of Salmonella Enterica Subspecies Enterica Serovar Typhi Isolates From Kelantan Using Random Amplified Polymorphic Dna And Single Nucleotide Polymorphism
description Typhoid fever is an acute systemic infection of humans caused by Salmonella enterica subspecies enterica serovar Typhi (S. Typhi). Typhoid fever is endemic in Kelantan, a North-eastern state in Peninsular Malaysia. In spite of extensive intervention by the state‘s Public Health Department, outbreaks of typhoid fever continue to occur with the emergence of multi-drug resistant strains. An important strategy to eradicate this persistent disease is to identify the sources and distribution of infection; and for this, a reliable S. Typhi fingerprinting method is needed. Confirmation of the bacteria by phenotypic techniques is difficult due to the vast number of serovars (>1,500) within the subspecies enterica. Current molecular typing methods offer very high discriminatory resolutions; however, the majority are limited in identifying phylogenetic relationships, evolutionary trends or genotypic characteristics. Thus, the main objective of this study was to investigate the effect of nucleotide sequence variations in S. Typhi in relation to its phylogenetic diversity, and to identify possible epidemiological markers for easy identification and confirmation of this pathogen. Two methods were used in this study.
format Thesis
author Ja’afar, Ja’afar Nuhu
author_facet Ja’afar, Ja’afar Nuhu
author_sort Ja’afar, Ja’afar Nuhu
title Molecular Epidemiology Of Salmonella Enterica Subspecies Enterica Serovar Typhi Isolates From Kelantan Using Random Amplified Polymorphic Dna And Single Nucleotide Polymorphism
title_short Molecular Epidemiology Of Salmonella Enterica Subspecies Enterica Serovar Typhi Isolates From Kelantan Using Random Amplified Polymorphic Dna And Single Nucleotide Polymorphism
title_full Molecular Epidemiology Of Salmonella Enterica Subspecies Enterica Serovar Typhi Isolates From Kelantan Using Random Amplified Polymorphic Dna And Single Nucleotide Polymorphism
title_fullStr Molecular Epidemiology Of Salmonella Enterica Subspecies Enterica Serovar Typhi Isolates From Kelantan Using Random Amplified Polymorphic Dna And Single Nucleotide Polymorphism
title_full_unstemmed Molecular Epidemiology Of Salmonella Enterica Subspecies Enterica Serovar Typhi Isolates From Kelantan Using Random Amplified Polymorphic Dna And Single Nucleotide Polymorphism
title_sort molecular epidemiology of salmonella enterica subspecies enterica serovar typhi isolates from kelantan using random amplified polymorphic dna and single nucleotide polymorphism
publishDate 2014
url http://eprints.usm.my/46114/1/Ja%E2%80%99afar%20Nuhu%20Ja%E2%80%99afar24.pdf
http://eprints.usm.my/46114/
_version_ 1662755740745465856
score 13.211869

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