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Survival time and prognostic factors of AIDS patients in Kelantan : 2010-2014

Background: The AIDS death is still a worldwide concern as well as in Kelantan. However, the median survival time and predictor factors that contributing to risk of death among AIDS patients in Kelantan were unknown. Objectives: To determine the overall median survival time and survival rate of A...

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Main Author: Ngah, Hamiza
Format: Thesis
Language:English
Published: 2018
Subjects:
RA643-645 Disease (Communicable and noninfectious) and public health
Online Access:http://eprints.usm.my/45899/1/Dr.%20Hamiza%20Ngah-24%20pages.pdf
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spelling my.usm.eprints.45899 http://eprints.usm.my/45899/ Survival time and prognostic factors of AIDS patients in Kelantan : 2010-2014 Ngah, Hamiza RA643-645 Disease (Communicable and noninfectious) and public health Background: The AIDS death is still a worldwide concern as well as in Kelantan. However, the median survival time and predictor factors that contributing to risk of death among AIDS patients in Kelantan were unknown. Objectives: To determine the overall median survival time and survival rate of AIDS patients and predictors factors of death in Kelantan population from 2010 to 2014. Methodology: A retrospective cohort study was conducted in January 2018 using secondary data obtained from National AIDS Registry for the period of 1st January 2010 to 31st December 2014 and followed-up until 31st Mac 2015. A complete 1073 data was selected for descriptive analysis and survival analysis. Kaplan- Meier survival analysis and Cox’s proportional hazard regression model with estimates of hazard ratio and 95% confidence interval were used. Result: The mean (SD) age was 37.08 (7.37). The patients were predominantly males (87.0%), Malays (87.5%), single (62.3%), unemployed (38.0%), with background of secondary education (78.1%) and cases without HIV-TB co-infection (62.8%). Approximately 53% of the patients death during follow-up. The overall median survival time was 11 months. The probability of survival in 1-year, 2-year and 5-year were 49.1%, 47.8%, and 46.7% respectively. Multivariate Cox regression showed that significant prognostic factors were age 30-49 years (Adj. HR 1.57; 95% CI: 1.14, 2.16; p=0.006), male (Adj. HR 1.39; 95% CI: 1.07, 1.79; p=0.012), unemployed (Adj. HR1.40; 95% CI: 1.12, 1.75; p=0.003) and HIV-TB co-infection (Adj. HR 1.78; 95% CI: 1.37, 2.31; p<0.001). Conclusion: The overall median survival time among AIDS patients in Kelantan was still low. To increase the survival among AIDS patients, every effort need to be made to ensure early screening, early diagnosis, early intervention and comprehensive management involving initiating HAART treatment as soon as possible in treating HIV/AIDS patients before they progress to AIDS-related death. 2018-05 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/45899/1/Dr.%20Hamiza%20Ngah-24%20pages.pdf Ngah, Hamiza (2018) Survival time and prognostic factors of AIDS patients in Kelantan : 2010-2014. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RA643-645 Disease (Communicable and noninfectious) and public health
spellingShingle RA643-645 Disease (Communicable and noninfectious) and public health
Ngah, Hamiza
Survival time and prognostic factors of AIDS patients in Kelantan : 2010-2014
description Background: The AIDS death is still a worldwide concern as well as in Kelantan. However, the median survival time and predictor factors that contributing to risk of death among AIDS patients in Kelantan were unknown. Objectives: To determine the overall median survival time and survival rate of AIDS patients and predictors factors of death in Kelantan population from 2010 to 2014. Methodology: A retrospective cohort study was conducted in January 2018 using secondary data obtained from National AIDS Registry for the period of 1st January 2010 to 31st December 2014 and followed-up until 31st Mac 2015. A complete 1073 data was selected for descriptive analysis and survival analysis. Kaplan- Meier survival analysis and Cox’s proportional hazard regression model with estimates of hazard ratio and 95% confidence interval were used. Result: The mean (SD) age was 37.08 (7.37). The patients were predominantly males (87.0%), Malays (87.5%), single (62.3%), unemployed (38.0%), with background of secondary education (78.1%) and cases without HIV-TB co-infection (62.8%). Approximately 53% of the patients death during follow-up. The overall median survival time was 11 months. The probability of survival in 1-year, 2-year and 5-year were 49.1%, 47.8%, and 46.7% respectively. Multivariate Cox regression showed that significant prognostic factors were age 30-49 years (Adj. HR 1.57; 95% CI: 1.14, 2.16; p=0.006), male (Adj. HR 1.39; 95% CI: 1.07, 1.79; p=0.012), unemployed (Adj. HR1.40; 95% CI: 1.12, 1.75; p=0.003) and HIV-TB co-infection (Adj. HR 1.78; 95% CI: 1.37, 2.31; p<0.001). Conclusion: The overall median survival time among AIDS patients in Kelantan was still low. To increase the survival among AIDS patients, every effort need to be made to ensure early screening, early diagnosis, early intervention and comprehensive management involving initiating HAART treatment as soon as possible in treating HIV/AIDS patients before they progress to AIDS-related death.
format Thesis
author Ngah, Hamiza
author_facet Ngah, Hamiza
author_sort Ngah, Hamiza
title Survival time and prognostic factors of AIDS patients in Kelantan : 2010-2014
title_short Survival time and prognostic factors of AIDS patients in Kelantan : 2010-2014
title_full Survival time and prognostic factors of AIDS patients in Kelantan : 2010-2014
title_fullStr Survival time and prognostic factors of AIDS patients in Kelantan : 2010-2014
title_full_unstemmed Survival time and prognostic factors of AIDS patients in Kelantan : 2010-2014
title_sort survival time and prognostic factors of aids patients in kelantan : 2010-2014
publishDate 2018
url http://eprints.usm.my/45899/1/Dr.%20Hamiza%20Ngah-24%20pages.pdf
http://eprints.usm.my/45899/
_version_ 1657488783688335360
score 13.211869

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