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Defeciancy Of Puma And Noxa For Melanomagenesis In A Mouse Model Of Melanoma

It is commonly believed without sufficient evidence that the impairment of the ability to undergo apoptosis (a mode of programmed cell death) in response to conventional treatment such as cytotoxic drugs, gained melanoma its notorious resistance to therapy. Studies to determine the contribution of t...

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Main Author: Phang,, Su Ling
Format: Thesis
Language:English
Published: 2017
Subjects:
QH1 Natural history (General - Including nature conservation, geographical distribution)
Online Access:http://eprints.usm.my/45479/1/PHANG%20SU%20LING.pdf
http://eprints.usm.my/45479/
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spelling my.usm.eprints.45479 http://eprints.usm.my/45479/ Defeciancy Of Puma And Noxa For Melanomagenesis In A Mouse Model Of Melanoma Phang,, Su Ling QH1 Natural history (General - Including nature conservation, geographical distribution) It is commonly believed without sufficient evidence that the impairment of the ability to undergo apoptosis (a mode of programmed cell death) in response to conventional treatment such as cytotoxic drugs, gained melanoma its notorious resistance to therapy. Studies to determine the contribution of the intrinsic apoptosis pathway for melanomagenesis are often deterred by utilisation of in vitro cell culture models and xenograft models. An established mouse model of melanoma, the Cdkn2a -/-, Tyr-HRASG12V, was utilised in this study to obviate limitations posted by the usage of in vitro and xenograft models. 2017-07 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/45479/1/PHANG%20SU%20LING.pdf Phang,, Su Ling (2017) Defeciancy Of Puma And Noxa For Melanomagenesis In A Mouse Model Of Melanoma. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic QH1 Natural history (General - Including nature conservation, geographical distribution)
spellingShingle QH1 Natural history (General - Including nature conservation, geographical distribution)
Phang,, Su Ling
Defeciancy Of Puma And Noxa For Melanomagenesis In A Mouse Model Of Melanoma
description It is commonly believed without sufficient evidence that the impairment of the ability to undergo apoptosis (a mode of programmed cell death) in response to conventional treatment such as cytotoxic drugs, gained melanoma its notorious resistance to therapy. Studies to determine the contribution of the intrinsic apoptosis pathway for melanomagenesis are often deterred by utilisation of in vitro cell culture models and xenograft models. An established mouse model of melanoma, the Cdkn2a -/-, Tyr-HRASG12V, was utilised in this study to obviate limitations posted by the usage of in vitro and xenograft models.
format Thesis
author Phang,, Su Ling
author_facet Phang,, Su Ling
author_sort Phang,, Su Ling
title Defeciancy Of Puma And Noxa For Melanomagenesis In A Mouse Model Of Melanoma
title_short Defeciancy Of Puma And Noxa For Melanomagenesis In A Mouse Model Of Melanoma
title_full Defeciancy Of Puma And Noxa For Melanomagenesis In A Mouse Model Of Melanoma
title_fullStr Defeciancy Of Puma And Noxa For Melanomagenesis In A Mouse Model Of Melanoma
title_full_unstemmed Defeciancy Of Puma And Noxa For Melanomagenesis In A Mouse Model Of Melanoma
title_sort defeciancy of puma and noxa for melanomagenesis in a mouse model of melanoma
publishDate 2017
url http://eprints.usm.my/45479/1/PHANG%20SU%20LING.pdf
http://eprints.usm.my/45479/
_version_ 1646011364491132928
score 13.211869

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