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Tualang Honey Attenuates Noise Stress-Induced Memory Deficits in Aged Rats

Ageing and stress exposure may lead to memory impairment while oxidative stress is thought to be one of the underlying mechanisms involved.This study aimed to investigate the potential protective effects of Tualang honey supplementation on memory performance in aged rats exposed to noise stress. T...

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Main Authors: Azman, Khairunnuur Fairuz, Zakaria, Rahimah, Aziz, Che Badariah Abdul, Othman, Zahiruddin
Format: Article
Language:English
Published: Hindawi Publishing Corporation 2016
Subjects:
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Online Access:http://eprints.usm.my/45334/1/OMCL2016%20-%20TH.pdf
http://eprints.usm.my/45334/
http://dx.doi.org/10.1155/2016/1549158
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spelling my.usm.eprints.45334 http://eprints.usm.my/45334/ Tualang Honey Attenuates Noise Stress-Induced Memory Deficits in Aged Rats Azman, Khairunnuur Fairuz Zakaria, Rahimah Aziz, Che Badariah Abdul Othman, Zahiruddin RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Ageing and stress exposure may lead to memory impairment while oxidative stress is thought to be one of the underlying mechanisms involved.This study aimed to investigate the potential protective effects of Tualang honey supplementation on memory performance in aged rats exposed to noise stress. Tualang honey supplementation was given orally, 200mg/kg body weight for 28 days. Rats in the stress groupwere subjected to loud noise, 100 dB(A), 4 hours daily for 14 days.All ratswere subjected to novel object recognition test for evaluation of memory performance. It was observed that the rats subjected to noise stress exhibited significantly lower memory performance and higher oxidative stress as evident by elevated malondialdehyde and protein carbonyl levels and reduction of antioxidant enzymes activities compared to the nonstressed rats. Tualang honey supplementation was able to improve memory performance, decrease oxidative stress levels, increase brain-derived neurotrophic factor (BDNF) concentration, decrease acetylcholinesterase activity, and enhance neuronal proliferation in the medial prefrontal cortex (mPFC) and hippocampus. In conclusion, Tualang honey protects against memory decline due to stress exposure and/or ageing via enhancement of mPFC and hippocampal morphology possibly secondary to reduction in brain oxidative stress and/or upregulation of BDNF concentration and cholinergic system. Hindawi Publishing Corporation 2016 Article PeerReviewed application/pdf en http://eprints.usm.my/45334/1/OMCL2016%20-%20TH.pdf Azman, Khairunnuur Fairuz and Zakaria, Rahimah and Aziz, Che Badariah Abdul and Othman, Zahiruddin (2016) Tualang Honey Attenuates Noise Stress-Induced Memory Deficits in Aged Rats. Oxidative Medicine and Cellular Longevity, 2016 (154915). pp. 1-11. ISSN 1942-0900 http://dx.doi.org/10.1155/2016/1549158
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
spellingShingle RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Azman, Khairunnuur Fairuz
Zakaria, Rahimah
Aziz, Che Badariah Abdul
Othman, Zahiruddin
Tualang Honey Attenuates Noise Stress-Induced Memory Deficits in Aged Rats
description Ageing and stress exposure may lead to memory impairment while oxidative stress is thought to be one of the underlying mechanisms involved.This study aimed to investigate the potential protective effects of Tualang honey supplementation on memory performance in aged rats exposed to noise stress. Tualang honey supplementation was given orally, 200mg/kg body weight for 28 days. Rats in the stress groupwere subjected to loud noise, 100 dB(A), 4 hours daily for 14 days.All ratswere subjected to novel object recognition test for evaluation of memory performance. It was observed that the rats subjected to noise stress exhibited significantly lower memory performance and higher oxidative stress as evident by elevated malondialdehyde and protein carbonyl levels and reduction of antioxidant enzymes activities compared to the nonstressed rats. Tualang honey supplementation was able to improve memory performance, decrease oxidative stress levels, increase brain-derived neurotrophic factor (BDNF) concentration, decrease acetylcholinesterase activity, and enhance neuronal proliferation in the medial prefrontal cortex (mPFC) and hippocampus. In conclusion, Tualang honey protects against memory decline due to stress exposure and/or ageing via enhancement of mPFC and hippocampal morphology possibly secondary to reduction in brain oxidative stress and/or upregulation of BDNF concentration and cholinergic system.
format Article
author Azman, Khairunnuur Fairuz
Zakaria, Rahimah
Aziz, Che Badariah Abdul
Othman, Zahiruddin
author_facet Azman, Khairunnuur Fairuz
Zakaria, Rahimah
Aziz, Che Badariah Abdul
Othman, Zahiruddin
author_sort Azman, Khairunnuur Fairuz
title Tualang Honey Attenuates Noise Stress-Induced Memory Deficits in Aged Rats
title_short Tualang Honey Attenuates Noise Stress-Induced Memory Deficits in Aged Rats
title_full Tualang Honey Attenuates Noise Stress-Induced Memory Deficits in Aged Rats
title_fullStr Tualang Honey Attenuates Noise Stress-Induced Memory Deficits in Aged Rats
title_full_unstemmed Tualang Honey Attenuates Noise Stress-Induced Memory Deficits in Aged Rats
title_sort tualang honey attenuates noise stress-induced memory deficits in aged rats
publisher Hindawi Publishing Corporation
publishDate 2016
url http://eprints.usm.my/45334/1/OMCL2016%20-%20TH.pdf
http://eprints.usm.my/45334/
http://dx.doi.org/10.1155/2016/1549158
_version_ 1646011322444283904
score 13.211869

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