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Tualang honey improves memory performance and decreases depressive-like behavior in rats exposed to loud noise stress

Recent evidence has exhibited dietary influence on the manifestation of different types of behavior induced by stressor tasks.The present study examined the effects of Tualang honey supplement administered with the goal of preventing or attenuating the occurrence of stress-related behaviors in male...

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Main Authors: Azman, Khairunnuur Fairuz, Zakaria, Rahimah, Aziz, Che Badariah Abd, Othman, Zahiruddin, Al-Rahbi, Badriya
Format: Article
Language:English
Published: Medknow Publications 2015
Subjects:
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Online Access:http://eprints.usm.my/45324/1/NoiseHealth_2015_17_75_83_153388%20%281%29.pdf
http://eprints.usm.my/45324/
https://doi.org/10.4103/1463-1741.153388
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spelling my.usm.eprints.45324 http://eprints.usm.my/45324/ Tualang honey improves memory performance and decreases depressive-like behavior in rats exposed to loud noise stress Azman, Khairunnuur Fairuz Zakaria, Rahimah Aziz, Che Badariah Abd Othman, Zahiruddin Al-Rahbi, Badriya RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Recent evidence has exhibited dietary influence on the manifestation of different types of behavior induced by stressor tasks.The present study examined the effects of Tualang honey supplement administered with the goal of preventing or attenuating the occurrence of stress-related behaviors in male rats subjected to noise stress. Forty-eight adult male rats were randomly divided into the following four groups: i) nonstressed with vehicle, ii) nonstressed with Tualang honey, iii) stressed with vehicle, and iv) stressed with honey. The supplement was given once daily via oral gavage at 0.2 g/kg body weight. Two types of behavioral tests were performed, namely, the novel object recognition test to evaluate working memory and the forced swimming test to evaluate depressive-like behavior. Data were analyzed by a two-way analysis of variance (ANOVA) using IBM SPSS 18.0. It was observed that the rats subjected to noise stress expressed higher levels of depressive-like behavior and lower memory functions compared to the unexposed control rats. In addition, our results indicated that the supplementation regimen successfully counteracted the effects of noise stress. The forced swimming test indicated that climbing and swimming times were significantly increased and immobility times significantly decreased in honey-supplemented rats, thereby demonstrating an antidepressant-like effect. Furthermore, cognitive function was shown to be intensely affected by noise stress, but the effects were counteracted by the honey supplement. These findings suggest that subchronic exposure to noise stress induces depressive-like behavior and reduces cognitive functions, and that these effects can be attenuated by Tualang honey supplementation. This warrants further studies to examine the role of Tulang honey in mediating such effects. Medknow Publications 2015 Article PeerReviewed application/pdf en http://eprints.usm.my/45324/1/NoiseHealth_2015_17_75_83_153388%20%281%29.pdf Azman, Khairunnuur Fairuz and Zakaria, Rahimah and Aziz, Che Badariah Abd and Othman, Zahiruddin and Al-Rahbi, Badriya (2015) Tualang honey improves memory performance and decreases depressive-like behavior in rats exposed to loud noise stress. Noise and Health, 17 (75). pp. 83-89. ISSN 1463-1741 https://doi.org/10.4103/1463-1741.153388
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
spellingShingle RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Azman, Khairunnuur Fairuz
Zakaria, Rahimah
Aziz, Che Badariah Abd
Othman, Zahiruddin
Al-Rahbi, Badriya
Tualang honey improves memory performance and decreases depressive-like behavior in rats exposed to loud noise stress
description Recent evidence has exhibited dietary influence on the manifestation of different types of behavior induced by stressor tasks.The present study examined the effects of Tualang honey supplement administered with the goal of preventing or attenuating the occurrence of stress-related behaviors in male rats subjected to noise stress. Forty-eight adult male rats were randomly divided into the following four groups: i) nonstressed with vehicle, ii) nonstressed with Tualang honey, iii) stressed with vehicle, and iv) stressed with honey. The supplement was given once daily via oral gavage at 0.2 g/kg body weight. Two types of behavioral tests were performed, namely, the novel object recognition test to evaluate working memory and the forced swimming test to evaluate depressive-like behavior. Data were analyzed by a two-way analysis of variance (ANOVA) using IBM SPSS 18.0. It was observed that the rats subjected to noise stress expressed higher levels of depressive-like behavior and lower memory functions compared to the unexposed control rats. In addition, our results indicated that the supplementation regimen successfully counteracted the effects of noise stress. The forced swimming test indicated that climbing and swimming times were significantly increased and immobility times significantly decreased in honey-supplemented rats, thereby demonstrating an antidepressant-like effect. Furthermore, cognitive function was shown to be intensely affected by noise stress, but the effects were counteracted by the honey supplement. These findings suggest that subchronic exposure to noise stress induces depressive-like behavior and reduces cognitive functions, and that these effects can be attenuated by Tualang honey supplementation. This warrants further studies to examine the role of Tulang honey in mediating such effects.
format Article
author Azman, Khairunnuur Fairuz
Zakaria, Rahimah
Aziz, Che Badariah Abd
Othman, Zahiruddin
Al-Rahbi, Badriya
author_facet Azman, Khairunnuur Fairuz
Zakaria, Rahimah
Aziz, Che Badariah Abd
Othman, Zahiruddin
Al-Rahbi, Badriya
author_sort Azman, Khairunnuur Fairuz
title Tualang honey improves memory performance and decreases depressive-like behavior in rats exposed to loud noise stress
title_short Tualang honey improves memory performance and decreases depressive-like behavior in rats exposed to loud noise stress
title_full Tualang honey improves memory performance and decreases depressive-like behavior in rats exposed to loud noise stress
title_fullStr Tualang honey improves memory performance and decreases depressive-like behavior in rats exposed to loud noise stress
title_full_unstemmed Tualang honey improves memory performance and decreases depressive-like behavior in rats exposed to loud noise stress
title_sort tualang honey improves memory performance and decreases depressive-like behavior in rats exposed to loud noise stress
publisher Medknow Publications
publishDate 2015
url http://eprints.usm.my/45324/1/NoiseHealth_2015_17_75_83_153388%20%281%29.pdf
http://eprints.usm.my/45324/
https://doi.org/10.4103/1463-1741.153388
_version_ 1646011319508271104
score 13.211869

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