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Neuroticism Is Associated with Chronic Severe Pain among Ex-Opioid Users on Methadone Maintenance Therapy

Introduction: Among ex-opioid users on methadone maintenance therapy (MMT), the prevalence of chronic severe pain (CSP) was reported as 37-48.2%. The CSP causes distress, adversely affects quality of life, addiction treatment outcome and exacerbates patients ambivalence towards MMT. Neuroticism pe...

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Main Authors: Chin, Hong Koh, Othman, Zahiruddin
Format: Article
Language:English
Published: Japan International Cultural Exchange Foundation 2019
Subjects:
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Online Access:http://eprints.usm.my/45294/1/15-Koh.pdf
http://eprints.usm.my/45294/
http://www.seronjihou.co.jp/IMJ/backnumber-IMJ.html
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spelling my.usm.eprints.45294 http://eprints.usm.my/45294/ Neuroticism Is Associated with Chronic Severe Pain among Ex-Opioid Users on Methadone Maintenance Therapy Chin, Hong Koh Othman, Zahiruddin RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Introduction: Among ex-opioid users on methadone maintenance therapy (MMT), the prevalence of chronic severe pain (CSP) was reported as 37-48.2%. The CSP causes distress, adversely affects quality of life, addiction treatment outcome and exacerbates patients ambivalence towards MMT. Neuroticism personality trait is associated with CSP, but the similar association has yet to be explored in ex-opioid users on MMT. Objectives: This study aims to determine the prevalence of CSP among ex-opioid users on MMT, and to examine whether neuroticism is significantly associated with CSP. Methods: In this cross-sectional study, validated Malay version of big five inventory (BFI), brief pain inventory (BPI), Beck's depression inventory (BDI), and Beck's anxiety inventory (BAI) were utilized for measurement of neuroticism, pain, depression and anxiety symptoms, respectively. Subjects were recruited from two MMT centres in Alor Star, Malaysia. Results: A total of 151 subjects were recruited, consisting of 104 from Klinik Kesihatan Bandar Alor Setar, and 47 from Hospital Sultanah Bahiyah. The prevalence of CSP, regular use of over-the-counter (OTC) analgesics and kratom product were 22.5%, 28.5%, and 40.4%, respectively. Using multiple logistic regression analyses, neuroticism score (p < 0.001), BAI score (p = 0.012) and regular OTC analgesic use (p = 0.016) were found to be statistically significant in association with CSP, with adjusted odds ratio of 1.60 (95% CI 1.27, 2.12), 1.44 (95% CI 1.08, 1.93), and 3.56 (95% CI 1.27, 10.01), respectively. Conclusion: Neuroticism, anxiety and regular use of OTC analgesics were independently associated with CSP among ex-opioid users on MMT. Otherwise, no significant association was observed for depression, HIV status, regular use of kratom, and other socio-demographic or clinical characteristics. Japan International Cultural Exchange Foundation 2019-02 Article PeerReviewed application/pdf en http://eprints.usm.my/45294/1/15-Koh.pdf Chin, Hong Koh and Othman, Zahiruddin (2019) Neuroticism Is Associated with Chronic Severe Pain among Ex-Opioid Users on Methadone Maintenance Therapy. International Medical Journal, 26 (1). pp. 15-18. ISSN 1341-2051 http://www.seronjihou.co.jp/IMJ/backnumber-IMJ.html
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
spellingShingle RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Chin, Hong Koh
Othman, Zahiruddin
Neuroticism Is Associated with Chronic Severe Pain among Ex-Opioid Users on Methadone Maintenance Therapy
description Introduction: Among ex-opioid users on methadone maintenance therapy (MMT), the prevalence of chronic severe pain (CSP) was reported as 37-48.2%. The CSP causes distress, adversely affects quality of life, addiction treatment outcome and exacerbates patients ambivalence towards MMT. Neuroticism personality trait is associated with CSP, but the similar association has yet to be explored in ex-opioid users on MMT. Objectives: This study aims to determine the prevalence of CSP among ex-opioid users on MMT, and to examine whether neuroticism is significantly associated with CSP. Methods: In this cross-sectional study, validated Malay version of big five inventory (BFI), brief pain inventory (BPI), Beck's depression inventory (BDI), and Beck's anxiety inventory (BAI) were utilized for measurement of neuroticism, pain, depression and anxiety symptoms, respectively. Subjects were recruited from two MMT centres in Alor Star, Malaysia. Results: A total of 151 subjects were recruited, consisting of 104 from Klinik Kesihatan Bandar Alor Setar, and 47 from Hospital Sultanah Bahiyah. The prevalence of CSP, regular use of over-the-counter (OTC) analgesics and kratom product were 22.5%, 28.5%, and 40.4%, respectively. Using multiple logistic regression analyses, neuroticism score (p < 0.001), BAI score (p = 0.012) and regular OTC analgesic use (p = 0.016) were found to be statistically significant in association with CSP, with adjusted odds ratio of 1.60 (95% CI 1.27, 2.12), 1.44 (95% CI 1.08, 1.93), and 3.56 (95% CI 1.27, 10.01), respectively. Conclusion: Neuroticism, anxiety and regular use of OTC analgesics were independently associated with CSP among ex-opioid users on MMT. Otherwise, no significant association was observed for depression, HIV status, regular use of kratom, and other socio-demographic or clinical characteristics.
format Article
author Chin, Hong Koh
Othman, Zahiruddin
author_facet Chin, Hong Koh
Othman, Zahiruddin
author_sort Chin, Hong Koh
title Neuroticism Is Associated with Chronic Severe Pain among Ex-Opioid Users on Methadone Maintenance Therapy
title_short Neuroticism Is Associated with Chronic Severe Pain among Ex-Opioid Users on Methadone Maintenance Therapy
title_full Neuroticism Is Associated with Chronic Severe Pain among Ex-Opioid Users on Methadone Maintenance Therapy
title_fullStr Neuroticism Is Associated with Chronic Severe Pain among Ex-Opioid Users on Methadone Maintenance Therapy
title_full_unstemmed Neuroticism Is Associated with Chronic Severe Pain among Ex-Opioid Users on Methadone Maintenance Therapy
title_sort neuroticism is associated with chronic severe pain among ex-opioid users on methadone maintenance therapy
publisher Japan International Cultural Exchange Foundation
publishDate 2019
url http://eprints.usm.my/45294/1/15-Koh.pdf
http://eprints.usm.my/45294/
http://www.seronjihou.co.jp/IMJ/backnumber-IMJ.html
_version_ 1643711244399542272
score 13.211869

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