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Association between index-to-ring finger length ratio (2D:4D) in female with knee osteoarthritis

Introduction: Osteoarthritis (OA) is a major public health problem and the most common cause of disability. There are gender differences in the prevalence, incidence and severity of knee and hip OA, especially knee OA affecting more women than men. Digit ratio (2D:4D) is defined as the ratio of t...

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Main Author: Mustapha, Mawardi
Format: Thesis
Language:English
Published: 2017
Subjects:
RC Internal medicine
Online Access:http://eprints.usm.my/45200/1/Dr.%20Mawardi%20Mustapha-24%20pages.pdf
http://eprints.usm.my/45200/
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spelling my.usm.eprints.45200 http://eprints.usm.my/45200/ Association between index-to-ring finger length ratio (2D:4D) in female with knee osteoarthritis Mustapha, Mawardi RC Internal medicine Introduction: Osteoarthritis (OA) is a major public health problem and the most common cause of disability. There are gender differences in the prevalence, incidence and severity of knee and hip OA, especially knee OA affecting more women than men. Digit ratio (2D:4D) is defined as the ratio of the length of index finger to length of ring finger. Lower digit ratio (2D:4D), is a proxy indicator of in-utero testosterone exposure, which was associated with aggression, risk taking behaviour as well as risk of total knee replacement for osteoarthritis. Objective: To determine the association of index-to-ring finger length ratio (2D:4D) in female with knee osteoarthritis and non-osteoarthritis (control) Methods: Comparative case control study was conducted, in which female patient with Osteoarthritis knees were compared with non-osteoarthritic female (control). Measurements will be taken from the tip of the respective finger to the basal crease. The length of the index finger (2D) will be divided by the length of the ring finger (4D) to obtain the 2D:4D ratio. The ratio was classified into 3 types. Type I (index longer than ring) common female pattern, type II (index=ring) intermediate pattern and type III (index shorter than ring) common male pattern. Results: A total of 136 female patients of OA and non OA each were selected in the study. In the OA, 48% (n = 66) were Type III 2D:4D ratio followed by Type I, 28% (n= 38) and Type II, 24% (n=32). Whereas, among non-osteoarthritis the highest 2D:4D ratio type was Type I which were 46%. With Pearson Chi Square Test, P-value obtained from the test was p < 0.001 which means there was statistically significant difference between 2D:4D ratio in female with knee OA and control. 2017 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/45200/1/Dr.%20Mawardi%20Mustapha-24%20pages.pdf Mustapha, Mawardi (2017) Association between index-to-ring finger length ratio (2D:4D) in female with knee osteoarthritis. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RC Internal medicine
spellingShingle RC Internal medicine
Mustapha, Mawardi
Association between index-to-ring finger length ratio (2D:4D) in female with knee osteoarthritis
description Introduction: Osteoarthritis (OA) is a major public health problem and the most common cause of disability. There are gender differences in the prevalence, incidence and severity of knee and hip OA, especially knee OA affecting more women than men. Digit ratio (2D:4D) is defined as the ratio of the length of index finger to length of ring finger. Lower digit ratio (2D:4D), is a proxy indicator of in-utero testosterone exposure, which was associated with aggression, risk taking behaviour as well as risk of total knee replacement for osteoarthritis. Objective: To determine the association of index-to-ring finger length ratio (2D:4D) in female with knee osteoarthritis and non-osteoarthritis (control) Methods: Comparative case control study was conducted, in which female patient with Osteoarthritis knees were compared with non-osteoarthritic female (control). Measurements will be taken from the tip of the respective finger to the basal crease. The length of the index finger (2D) will be divided by the length of the ring finger (4D) to obtain the 2D:4D ratio. The ratio was classified into 3 types. Type I (index longer than ring) common female pattern, type II (index=ring) intermediate pattern and type III (index shorter than ring) common male pattern. Results: A total of 136 female patients of OA and non OA each were selected in the study. In the OA, 48% (n = 66) were Type III 2D:4D ratio followed by Type I, 28% (n= 38) and Type II, 24% (n=32). Whereas, among non-osteoarthritis the highest 2D:4D ratio type was Type I which were 46%. With Pearson Chi Square Test, P-value obtained from the test was p < 0.001 which means there was statistically significant difference between 2D:4D ratio in female with knee OA and control.
format Thesis
author Mustapha, Mawardi
author_facet Mustapha, Mawardi
author_sort Mustapha, Mawardi
title Association between index-to-ring finger length ratio (2D:4D) in female with knee osteoarthritis
title_short Association between index-to-ring finger length ratio (2D:4D) in female with knee osteoarthritis
title_full Association between index-to-ring finger length ratio (2D:4D) in female with knee osteoarthritis
title_fullStr Association between index-to-ring finger length ratio (2D:4D) in female with knee osteoarthritis
title_full_unstemmed Association between index-to-ring finger length ratio (2D:4D) in female with knee osteoarthritis
title_sort association between index-to-ring finger length ratio (2d:4d) in female with knee osteoarthritis
publishDate 2017
url http://eprints.usm.my/45200/1/Dr.%20Mawardi%20Mustapha-24%20pages.pdf
http://eprints.usm.my/45200/
_version_ 1681490162763169792
score 13.211869

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