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Clozapine-Induced Myocarditis and Pericarditis

Objective: Clozapine is known to cause cardiac side-effects, including myocarditis, pericarditis and cardiomyopathy. A 50-year-old Malay man with schizoaffective disorder and tardive dyskinesia who developed transient tachycardia, low blood pressure and fever after 17 days of starting clozapine wa...

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Main Authors: Othman, Zahiruddin, Ahmad, Fazil, Halim, Ahmad Shahril Abdul, Ismail, Nurul Nadia
Format: Article
Language:English
Published: Japan International Cultural Exchange Foundation 2014
Subjects:
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Online Access:http://eprints.usm.my/44712/1/Clozapine-Induced%20Myocarditis%20and%20Pericarditis%20%282014%29.pdf
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spelling my.usm.eprints.44712 http://eprints.usm.my/44712/ Clozapine-Induced Myocarditis and Pericarditis Othman, Zahiruddin Ahmad, Fazil Halim, Ahmad Shahril Abdul Ismail, Nurul Nadia RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Objective: Clozapine is known to cause cardiac side-effects, including myocarditis, pericarditis and cardiomyopathy. A 50-year-old Malay man with schizoaffective disorder and tardive dyskinesia who developed transient tachycardia, low blood pressure and fever after 17 days of starting clozapine was studied. Result: Elevated creatinine kinase at 532 U/l along with WBC and neutrophil count at 21.40 and 16.83 x 1071 respectively indicated an acute myocarditis. Additionally, pericardium involvement was suggested by V1-V4 ST elevation and absence of T wave inversion. Conclusion: The emergence of tachycardia, low blood pressure and fever in patient who is recently started on clozapine treatment should be investigated for cardiac complications. Old age and concomitant treatment with sodium valproate possibly increased the risk of clozapine-induced cardiac side-effects Japan International Cultural Exchange Foundation 2014-12 Article PeerReviewed application/pdf en http://eprints.usm.my/44712/1/Clozapine-Induced%20Myocarditis%20and%20Pericarditis%20%282014%29.pdf Othman, Zahiruddin and Ahmad, Fazil and Halim, Ahmad Shahril Abdul and Ismail, Nurul Nadia (2014) Clozapine-Induced Myocarditis and Pericarditis. International Medical Journal, 21 (6). pp. 539-540. ISSN 1341-2051 http://www.seronjihou.co.jp/IMJ/backnumber-IMJ.html
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
spellingShingle RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Othman, Zahiruddin
Ahmad, Fazil
Halim, Ahmad Shahril Abdul
Ismail, Nurul Nadia
Clozapine-Induced Myocarditis and Pericarditis
description Objective: Clozapine is known to cause cardiac side-effects, including myocarditis, pericarditis and cardiomyopathy. A 50-year-old Malay man with schizoaffective disorder and tardive dyskinesia who developed transient tachycardia, low blood pressure and fever after 17 days of starting clozapine was studied. Result: Elevated creatinine kinase at 532 U/l along with WBC and neutrophil count at 21.40 and 16.83 x 1071 respectively indicated an acute myocarditis. Additionally, pericardium involvement was suggested by V1-V4 ST elevation and absence of T wave inversion. Conclusion: The emergence of tachycardia, low blood pressure and fever in patient who is recently started on clozapine treatment should be investigated for cardiac complications. Old age and concomitant treatment with sodium valproate possibly increased the risk of clozapine-induced cardiac side-effects
format Article
author Othman, Zahiruddin
Ahmad, Fazil
Halim, Ahmad Shahril Abdul
Ismail, Nurul Nadia
author_facet Othman, Zahiruddin
Ahmad, Fazil
Halim, Ahmad Shahril Abdul
Ismail, Nurul Nadia
author_sort Othman, Zahiruddin
title Clozapine-Induced Myocarditis and Pericarditis
title_short Clozapine-Induced Myocarditis and Pericarditis
title_full Clozapine-Induced Myocarditis and Pericarditis
title_fullStr Clozapine-Induced Myocarditis and Pericarditis
title_full_unstemmed Clozapine-Induced Myocarditis and Pericarditis
title_sort clozapine-induced myocarditis and pericarditis
publisher Japan International Cultural Exchange Foundation
publishDate 2014
url http://eprints.usm.my/44712/1/Clozapine-Induced%20Myocarditis%20and%20Pericarditis%20%282014%29.pdf
http://eprints.usm.my/44712/
http://www.seronjihou.co.jp/IMJ/backnumber-IMJ.html
_version_ 1643711084227461120
score 13.211869

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