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Ultrasound features in the diagnosis of biliary atresia

Objective: To assess the role of ultrasound (US) in the diagnosis of biliary atresia. Methodology: Fasting infants with conjugated hyperbilirubinemia were subjected for US examination in Hospital Sultanah Bahiyah, Kedah. The patients were grouped into biliary atresia (BA) and non-biliary atresia...

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Main Author: Khim, Sim See
Format: Thesis
Language:English
Published: 2017
Subjects:
R Medicine (General)
Online Access:http://eprints.usm.my/44632/1/Dr.%20Sim%20See%20Khim-24%20pages.pdf
http://eprints.usm.my/44632/
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spelling my.usm.eprints.44632 http://eprints.usm.my/44632/ Ultrasound features in the diagnosis of biliary atresia Khim, Sim See R Medicine (General) Objective: To assess the role of ultrasound (US) in the diagnosis of biliary atresia. Methodology: Fasting infants with conjugated hyperbilirubinemia were subjected for US examination in Hospital Sultanah Bahiyah, Kedah. The patients were grouped into biliary atresia (BA) and non-biliary atresia (non-BA) based on the surgical findings and clinical follow up. The following features were recorded: tri-angular cord sign, gall bladder morphology, liver size, and echotexture, splenic size, hepatic artery size, hepatic artery to portal vein ratio, presence of a common bile duct, and presence of subcapsular flow on colour Doppler. Sensitivity, specificity, positive and negative predictive values were calculated for each US variable. BA and non-BA groups were compared by using the Fisher exact test for categorical variables and an unpaired t test for continues variable. Results: A total of 82 infants were included in the study; 42 had surgically confirmed BA and 40 had other documented causes of neonatal jaundice. Nine US features showed a significant different between BA and non-BA group. Ultrasound able to correctly classified 82 infants into BA and non-BA group with 98% accuracy. Conclusions: BA can be diagnosed with US from other cause of conjugated hyperbilirubinemia in 98% of patients if multiple US features are carefully evaluated. These ultrasound variables may serve as independent predictors of BA. 2017 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/44632/1/Dr.%20Sim%20See%20Khim-24%20pages.pdf Khim, Sim See (2017) Ultrasound features in the diagnosis of biliary atresia. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Khim, Sim See
Ultrasound features in the diagnosis of biliary atresia
description Objective: To assess the role of ultrasound (US) in the diagnosis of biliary atresia. Methodology: Fasting infants with conjugated hyperbilirubinemia were subjected for US examination in Hospital Sultanah Bahiyah, Kedah. The patients were grouped into biliary atresia (BA) and non-biliary atresia (non-BA) based on the surgical findings and clinical follow up. The following features were recorded: tri-angular cord sign, gall bladder morphology, liver size, and echotexture, splenic size, hepatic artery size, hepatic artery to portal vein ratio, presence of a common bile duct, and presence of subcapsular flow on colour Doppler. Sensitivity, specificity, positive and negative predictive values were calculated for each US variable. BA and non-BA groups were compared by using the Fisher exact test for categorical variables and an unpaired t test for continues variable. Results: A total of 82 infants were included in the study; 42 had surgically confirmed BA and 40 had other documented causes of neonatal jaundice. Nine US features showed a significant different between BA and non-BA group. Ultrasound able to correctly classified 82 infants into BA and non-BA group with 98% accuracy. Conclusions: BA can be diagnosed with US from other cause of conjugated hyperbilirubinemia in 98% of patients if multiple US features are carefully evaluated. These ultrasound variables may serve as independent predictors of BA.
format Thesis
author Khim, Sim See
author_facet Khim, Sim See
author_sort Khim, Sim See
title Ultrasound features in the diagnosis of biliary atresia
title_short Ultrasound features in the diagnosis of biliary atresia
title_full Ultrasound features in the diagnosis of biliary atresia
title_fullStr Ultrasound features in the diagnosis of biliary atresia
title_full_unstemmed Ultrasound features in the diagnosis of biliary atresia
title_sort ultrasound features in the diagnosis of biliary atresia
publishDate 2017
url http://eprints.usm.my/44632/1/Dr.%20Sim%20See%20Khim-24%20pages.pdf
http://eprints.usm.my/44632/
_version_ 1681490156872269824
score 13.211869

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