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Retrospective study of the outcomes of necrotizing fasciitis in intensive care unit, Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan

Background: Necrotizing fasciitis is a rapidly progressive soft tissue infection involving deep fascia which carries relatively high mortality rate worldwide. The aim of this study is to determine the mortality rate in our local general hospital and to investigate the factors that determine the p...

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Main Author: Mustapa, Noor Shazlini
Format: Thesis
Language:English
Published: 2016
Subjects:
RE Ophthalmology
Online Access:http://eprints.usm.my/43620/1/Dr.%20Noor%20Shazlini%20Bt%20Mustapa-24%20pages.pdf
http://eprints.usm.my/43620/
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spelling my.usm.eprints.43620 http://eprints.usm.my/43620/ Retrospective study of the outcomes of necrotizing fasciitis in intensive care unit, Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan Mustapa, Noor Shazlini RE Ophthalmology Background: Necrotizing fasciitis is a rapidly progressive soft tissue infection involving deep fascia which carries relatively high mortality rate worldwide. The aim of this study is to determine the mortality rate in our local general hospital and to investigate the factors that determine the primary outcome (mortality) of the necrotizing fasciitis patients treated in Intensive Care Unit. Methods: This is retrospective cross sectional study involved 71 patients admitted to intensive care unit (ICU) HRPZ II from January 2012 to December 2015. Patients were analyzed for presence of co-morbidities, Acute Physiology and Chronic Health Evaluation (APACHE II score), factors important in pathogenesis and treatment, and mortality. Results: The overall mortality was 22/71(31%). The mean APACHE II score was 19.2 (SD=6.57) and the median time to operation was 50 hours (IQR=70.0). Factors directly contributing towards mortality were higher APACHE II score (adjusted OR 1.41, 95%CI: 1.20, 1.66, P< 0.001) and an increase in time to surgical debridement (adjusted OR 1.03, 95%CI: 1.01, 1.05, P=0.003) Conclusion: Early surgical debridement was crucial in the treating the necrotizing fasciitis. High APACHE 11 score during admission was associated with increase mortality. 2016 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/43620/1/Dr.%20Noor%20Shazlini%20Bt%20Mustapa-24%20pages.pdf Mustapa, Noor Shazlini (2016) Retrospective study of the outcomes of necrotizing fasciitis in intensive care unit, Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RE Ophthalmology
spellingShingle RE Ophthalmology
Mustapa, Noor Shazlini
Retrospective study of the outcomes of necrotizing fasciitis in intensive care unit, Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan
description Background: Necrotizing fasciitis is a rapidly progressive soft tissue infection involving deep fascia which carries relatively high mortality rate worldwide. The aim of this study is to determine the mortality rate in our local general hospital and to investigate the factors that determine the primary outcome (mortality) of the necrotizing fasciitis patients treated in Intensive Care Unit. Methods: This is retrospective cross sectional study involved 71 patients admitted to intensive care unit (ICU) HRPZ II from January 2012 to December 2015. Patients were analyzed for presence of co-morbidities, Acute Physiology and Chronic Health Evaluation (APACHE II score), factors important in pathogenesis and treatment, and mortality. Results: The overall mortality was 22/71(31%). The mean APACHE II score was 19.2 (SD=6.57) and the median time to operation was 50 hours (IQR=70.0). Factors directly contributing towards mortality were higher APACHE II score (adjusted OR 1.41, 95%CI: 1.20, 1.66, P< 0.001) and an increase in time to surgical debridement (adjusted OR 1.03, 95%CI: 1.01, 1.05, P=0.003) Conclusion: Early surgical debridement was crucial in the treating the necrotizing fasciitis. High APACHE 11 score during admission was associated with increase mortality.
format Thesis
author Mustapa, Noor Shazlini
author_facet Mustapa, Noor Shazlini
author_sort Mustapa, Noor Shazlini
title Retrospective study of the outcomes of necrotizing fasciitis in intensive care unit, Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan
title_short Retrospective study of the outcomes of necrotizing fasciitis in intensive care unit, Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan
title_full Retrospective study of the outcomes of necrotizing fasciitis in intensive care unit, Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan
title_fullStr Retrospective study of the outcomes of necrotizing fasciitis in intensive care unit, Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan
title_full_unstemmed Retrospective study of the outcomes of necrotizing fasciitis in intensive care unit, Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan
title_sort retrospective study of the outcomes of necrotizing fasciitis in intensive care unit, hospital raja perempuan zainab ii, kota bharu, kelantan
publishDate 2016
url http://eprints.usm.my/43620/1/Dr.%20Noor%20Shazlini%20Bt%20Mustapa-24%20pages.pdf
http://eprints.usm.my/43620/
_version_ 1643710790037929984
score 13.211869

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