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Magnetic resonance imaging evaluation of the effect of tualang honey in breast tissue among postmenopausal breast cancer patient treated with anastrazole in HUSM

Objective: To investigate whether the combination treatment with Tualang honey (TH) influences the background parenchymal enhancement (BPE) at breast magnetic resonance imaging (MRI) in postmenopausal women with history of breast cancer treated with anastrozole. Methodology: A total of 22 patien...

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Main Author: Nik Lah, Nik Shah Hizan
Format: Thesis
Language:English
Published: 2016
Subjects:
R Medicine (General)
Online Access:http://eprints.usm.my/43499/1/Dr.%20Nik%20Shah%20Hizan-24%20pages.pdf
http://eprints.usm.my/43499/
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spelling my.usm.eprints.43499 http://eprints.usm.my/43499/ Magnetic resonance imaging evaluation of the effect of tualang honey in breast tissue among postmenopausal breast cancer patient treated with anastrazole in HUSM Nik Lah, Nik Shah Hizan R Medicine (General) Objective: To investigate whether the combination treatment with Tualang honey (TH) influences the background parenchymal enhancement (BPE) at breast magnetic resonance imaging (MRI) in postmenopausal women with history of breast cancer treated with anastrozole. Methodology: A total of 22 patients were recruited for both control (1 mg anastrozole daily) and intervention (1 mg anastrozole daily + 20 mg TH daily) groups from Oncology Clinic, Hospital USM, Kubang Kerian, Kelantan. Inclusive criteria included postmenopausal women with unilateral breast cancer stages I, II, or III, oestrogen receptor (ER) positive and/or progesterone receptor (PgR) positive and receiving anastrazole as treatment for or less a year were included. The BPE of contralateral breast before and 6 months after treatment was compared side by side using sign test. Results: A decrease in BPE was noted in 10% of women (p = 0.317) on anastrozole treatment, resulted in a category change of BPE from moderate to mild. The combination of anastrozole and TH treatment showed a decrease in BPE in 42% (p = 0.034) of postmenopausal breast cancer women. BPE decreased by one category of assessment in four women and by two categories of assessment in one woman. Conclusions: The combination of TH and anastrozole is more efficacious than anastrozole alone in decreasing breast BPE of ER-positive postmenopausal breast cancer women and thus reducing the risk of cancer recurrence. These findings further support the medicinal value of TH. 2016 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/43499/1/Dr.%20Nik%20Shah%20Hizan-24%20pages.pdf Nik Lah, Nik Shah Hizan (2016) Magnetic resonance imaging evaluation of the effect of tualang honey in breast tissue among postmenopausal breast cancer patient treated with anastrazole in HUSM. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Nik Lah, Nik Shah Hizan
Magnetic resonance imaging evaluation of the effect of tualang honey in breast tissue among postmenopausal breast cancer patient treated with anastrazole in HUSM
description Objective: To investigate whether the combination treatment with Tualang honey (TH) influences the background parenchymal enhancement (BPE) at breast magnetic resonance imaging (MRI) in postmenopausal women with history of breast cancer treated with anastrozole. Methodology: A total of 22 patients were recruited for both control (1 mg anastrozole daily) and intervention (1 mg anastrozole daily + 20 mg TH daily) groups from Oncology Clinic, Hospital USM, Kubang Kerian, Kelantan. Inclusive criteria included postmenopausal women with unilateral breast cancer stages I, II, or III, oestrogen receptor (ER) positive and/or progesterone receptor (PgR) positive and receiving anastrazole as treatment for or less a year were included. The BPE of contralateral breast before and 6 months after treatment was compared side by side using sign test. Results: A decrease in BPE was noted in 10% of women (p = 0.317) on anastrozole treatment, resulted in a category change of BPE from moderate to mild. The combination of anastrozole and TH treatment showed a decrease in BPE in 42% (p = 0.034) of postmenopausal breast cancer women. BPE decreased by one category of assessment in four women and by two categories of assessment in one woman. Conclusions: The combination of TH and anastrozole is more efficacious than anastrozole alone in decreasing breast BPE of ER-positive postmenopausal breast cancer women and thus reducing the risk of cancer recurrence. These findings further support the medicinal value of TH.
format Thesis
author Nik Lah, Nik Shah Hizan
author_facet Nik Lah, Nik Shah Hizan
author_sort Nik Lah, Nik Shah Hizan
title Magnetic resonance imaging evaluation of the effect of tualang honey in breast tissue among postmenopausal breast cancer patient treated with anastrazole in HUSM
title_short Magnetic resonance imaging evaluation of the effect of tualang honey in breast tissue among postmenopausal breast cancer patient treated with anastrazole in HUSM
title_full Magnetic resonance imaging evaluation of the effect of tualang honey in breast tissue among postmenopausal breast cancer patient treated with anastrazole in HUSM
title_fullStr Magnetic resonance imaging evaluation of the effect of tualang honey in breast tissue among postmenopausal breast cancer patient treated with anastrazole in HUSM
title_full_unstemmed Magnetic resonance imaging evaluation of the effect of tualang honey in breast tissue among postmenopausal breast cancer patient treated with anastrazole in HUSM
title_sort magnetic resonance imaging evaluation of the effect of tualang honey in breast tissue among postmenopausal breast cancer patient treated with anastrazole in husm
publishDate 2016
url http://eprints.usm.my/43499/1/Dr.%20Nik%20Shah%20Hizan-24%20pages.pdf
http://eprints.usm.my/43499/
_version_ 1643710759963721728
score 13.211869

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