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Recombinant Ns3 Serine Protease From Dengue Virus 2 As A Screen For Small Molecules

Dengue infection is re-emerging as a major global disease and is classified as a Category A priority pathogen. Dengue viruses are estimated to infect 50-100 million people annually and are considered to cause one of the most important arthropod-borne viral diseases in terms of human morbidity and mo...

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Main Author: Ab Aziz, Nurohaida
Format: Thesis
Language:English
Published: 2011
Subjects:
QH1 Natural history (General - Including nature conservation, geographical distribution)
Online Access:http://eprints.usm.my/43456/1/NUROHAIDA%20AB%20AZIZ.pdf
http://eprints.usm.my/43456/
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spelling my.usm.eprints.43456 http://eprints.usm.my/43456/ Recombinant Ns3 Serine Protease From Dengue Virus 2 As A Screen For Small Molecules Ab Aziz, Nurohaida QH1 Natural history (General - Including nature conservation, geographical distribution) Dengue infection is re-emerging as a major global disease and is classified as a Category A priority pathogen. Dengue viruses are estimated to infect 50-100 million people annually and are considered to cause one of the most important arthropod-borne viral diseases in terms of human morbidity and mortality. Virus transmission occurs through the bite of the Aedes aegypti mosquito and half the world’s population is at risk for infection. There is presently no approved vaccine or antiviral drug that is effective against dengue viruses. The focus of this thesis is to combine the power of high performance computing with wet lab experiments for the recombinant NS3 serine protease from dengue virus type 2 as a screen for antiviral small molecules that can be used either to prevent or treat dengue virus infections. 2011-08 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/43456/1/NUROHAIDA%20AB%20AZIZ.pdf Ab Aziz, Nurohaida (2011) Recombinant Ns3 Serine Protease From Dengue Virus 2 As A Screen For Small Molecules. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic QH1 Natural history (General - Including nature conservation, geographical distribution)
spellingShingle QH1 Natural history (General - Including nature conservation, geographical distribution)
Ab Aziz, Nurohaida
Recombinant Ns3 Serine Protease From Dengue Virus 2 As A Screen For Small Molecules
description Dengue infection is re-emerging as a major global disease and is classified as a Category A priority pathogen. Dengue viruses are estimated to infect 50-100 million people annually and are considered to cause one of the most important arthropod-borne viral diseases in terms of human morbidity and mortality. Virus transmission occurs through the bite of the Aedes aegypti mosquito and half the world’s population is at risk for infection. There is presently no approved vaccine or antiviral drug that is effective against dengue viruses. The focus of this thesis is to combine the power of high performance computing with wet lab experiments for the recombinant NS3 serine protease from dengue virus type 2 as a screen for antiviral small molecules that can be used either to prevent or treat dengue virus infections.
format Thesis
author Ab Aziz, Nurohaida
author_facet Ab Aziz, Nurohaida
author_sort Ab Aziz, Nurohaida
title Recombinant Ns3 Serine Protease From Dengue Virus 2 As A Screen For Small Molecules
title_short Recombinant Ns3 Serine Protease From Dengue Virus 2 As A Screen For Small Molecules
title_full Recombinant Ns3 Serine Protease From Dengue Virus 2 As A Screen For Small Molecules
title_fullStr Recombinant Ns3 Serine Protease From Dengue Virus 2 As A Screen For Small Molecules
title_full_unstemmed Recombinant Ns3 Serine Protease From Dengue Virus 2 As A Screen For Small Molecules
title_sort recombinant ns3 serine protease from dengue virus 2 as a screen for small molecules
publishDate 2011
url http://eprints.usm.my/43456/1/NUROHAIDA%20AB%20AZIZ.pdf
http://eprints.usm.my/43456/
_version_ 1643710748699918336
score 13.211869

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