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Effects Of Mitragyna Speciosa Extracts On Drug Metabolizing Enzymes

M. speciosa (ketum) leaves have been employed traditionally in Malaysia and Thailand to wean opium addiction and as a substitute for opium when opium is unavailable. M. speciosa leaves have been abused by drug addicts since some of the alkaloids (mainly mitragynine) from the plant possess opiate and...

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Main Author: Azizi, Juzaili
Format: Thesis
Language:English
Published: 2011
Subjects:
RS Pharmacy and materia medica
Online Access:http://eprints.usm.my/43353/1/JUZAILI%20AZIZI.pdf
http://eprints.usm.my/43353/
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spelling my.usm.eprints.43353 http://eprints.usm.my/43353/ Effects Of Mitragyna Speciosa Extracts On Drug Metabolizing Enzymes Azizi, Juzaili RS Pharmacy and materia medica M. speciosa (ketum) leaves have been employed traditionally in Malaysia and Thailand to wean opium addiction and as a substitute for opium when opium is unavailable. M. speciosa leaves have been abused by drug addicts since some of the alkaloids (mainly mitragynine) from the plant possess opiate and cocaine like effects. These bring to its prohibition in Malaysia in 2004 since consumption of M. speciosa leaves has been perceived to lead to the abuse of other drugs such as cannabis and heroin. In the current study, the in vitro and in vivo effects of M. speciosa methanolic, aqueous and total alkaloid extracts on drug metabolizing enzymes, namely cytochrome P450 (CYP450), UDP-glucuronosyl transferase (UGT) and glutathione S-transferase (GST) had been evaluated in rat liver cytosolic fraction and microsomes. 2011-10 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/43353/1/JUZAILI%20AZIZI.pdf Azizi, Juzaili (2011) Effects Of Mitragyna Speciosa Extracts On Drug Metabolizing Enzymes. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RS Pharmacy and materia medica
spellingShingle RS Pharmacy and materia medica
Azizi, Juzaili
Effects Of Mitragyna Speciosa Extracts On Drug Metabolizing Enzymes
description M. speciosa (ketum) leaves have been employed traditionally in Malaysia and Thailand to wean opium addiction and as a substitute for opium when opium is unavailable. M. speciosa leaves have been abused by drug addicts since some of the alkaloids (mainly mitragynine) from the plant possess opiate and cocaine like effects. These bring to its prohibition in Malaysia in 2004 since consumption of M. speciosa leaves has been perceived to lead to the abuse of other drugs such as cannabis and heroin. In the current study, the in vitro and in vivo effects of M. speciosa methanolic, aqueous and total alkaloid extracts on drug metabolizing enzymes, namely cytochrome P450 (CYP450), UDP-glucuronosyl transferase (UGT) and glutathione S-transferase (GST) had been evaluated in rat liver cytosolic fraction and microsomes.
format Thesis
author Azizi, Juzaili
author_facet Azizi, Juzaili
author_sort Azizi, Juzaili
title Effects Of Mitragyna Speciosa Extracts On Drug Metabolizing Enzymes
title_short Effects Of Mitragyna Speciosa Extracts On Drug Metabolizing Enzymes
title_full Effects Of Mitragyna Speciosa Extracts On Drug Metabolizing Enzymes
title_fullStr Effects Of Mitragyna Speciosa Extracts On Drug Metabolizing Enzymes
title_full_unstemmed Effects Of Mitragyna Speciosa Extracts On Drug Metabolizing Enzymes
title_sort effects of mitragyna speciosa extracts on drug metabolizing enzymes
publishDate 2011
url http://eprints.usm.my/43353/1/JUZAILI%20AZIZI.pdf
http://eprints.usm.my/43353/
_version_ 1643710720631635968
score 13.211869

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