Cover Image

Human natural killer (NK) cell activation by luteolin from Brucea javanica leaves

There is growing interest in using natural substances from plants to potentially enhance anticancer activity. A key target in this respect is natural killer (NK) cells in order to generate an anticancerimmune response. Luteolin used in this study was derived from a local plant Brucea javanica leave...

Full description

Saved in:
Bibliographic Details
Main Authors: Ismail, Norzila, Abdullah, Hasmah, Seidel, Veronique, Rotondo, Dino
Format: Article
Language:English
Published: Academic Journals 2018
Subjects:
RA0421 Public health. Hygiene. Preventive Medicine
Online Access:http://eprints.usm.my/43296/1/B3D352E59611.pdf
http://eprints.usm.my/43296/
https://doi.org/10.5897/JCREO2012.012
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.usm.eprints.43296
record_format eprints
spelling my.usm.eprints.43296 http://eprints.usm.my/43296/ Human natural killer (NK) cell activation by luteolin from Brucea javanica leaves Ismail, Norzila Abdullah, Hasmah Seidel, Veronique Rotondo, Dino RA0421 Public health. Hygiene. Preventive Medicine There is growing interest in using natural substances from plants to potentially enhance anticancer activity. A key target in this respect is natural killer (NK) cells in order to generate an anticancerimmune response. Luteolin used in this study was derived from a local plant Brucea javanica leaves extract; through a bioassay-guided fractionation. The expression of interleukin-2 (IL-2) and interferon-γ (IFN-γ) was increased after 20 h treatment of 0.1 µM luteolin in human mixed lymphocytes, which reflects the activation of NK cells. This was further confirmed in co-culture experiments. NK cellinduced K562 target cell death was increased in the presence of luteolin. These results show that luteolin activates NK cells to kill target cells indicating the potential use of luteolin as an anticancer immunostimulant. Academic Journals 2018 Article PeerReviewed application/pdf en http://eprints.usm.my/43296/1/B3D352E59611.pdf Ismail, Norzila and Abdullah, Hasmah and Seidel, Veronique and Rotondo, Dino (2018) Human natural killer (NK) cell activation by luteolin from Brucea javanica leaves. Journal of Cancer Research and Experimental Oncology, 10 (2). pp. 10-14. ISSN 2141-2243 https://doi.org/10.5897/JCREO2012.012
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RA0421 Public health. Hygiene. Preventive Medicine
spellingShingle RA0421 Public health. Hygiene. Preventive Medicine
Ismail, Norzila
Abdullah, Hasmah
Seidel, Veronique
Rotondo, Dino
Human natural killer (NK) cell activation by luteolin from Brucea javanica leaves
description There is growing interest in using natural substances from plants to potentially enhance anticancer activity. A key target in this respect is natural killer (NK) cells in order to generate an anticancerimmune response. Luteolin used in this study was derived from a local plant Brucea javanica leaves extract; through a bioassay-guided fractionation. The expression of interleukin-2 (IL-2) and interferon-γ (IFN-γ) was increased after 20 h treatment of 0.1 µM luteolin in human mixed lymphocytes, which reflects the activation of NK cells. This was further confirmed in co-culture experiments. NK cellinduced K562 target cell death was increased in the presence of luteolin. These results show that luteolin activates NK cells to kill target cells indicating the potential use of luteolin as an anticancer immunostimulant.
format Article
author Ismail, Norzila
Abdullah, Hasmah
Seidel, Veronique
Rotondo, Dino
author_facet Ismail, Norzila
Abdullah, Hasmah
Seidel, Veronique
Rotondo, Dino
author_sort Ismail, Norzila
title Human natural killer (NK) cell activation by luteolin from Brucea javanica leaves
title_short Human natural killer (NK) cell activation by luteolin from Brucea javanica leaves
title_full Human natural killer (NK) cell activation by luteolin from Brucea javanica leaves
title_fullStr Human natural killer (NK) cell activation by luteolin from Brucea javanica leaves
title_full_unstemmed Human natural killer (NK) cell activation by luteolin from Brucea javanica leaves
title_sort human natural killer (nk) cell activation by luteolin from brucea javanica leaves
publisher Academic Journals
publishDate 2018
url http://eprints.usm.my/43296/1/B3D352E59611.pdf
http://eprints.usm.my/43296/
https://doi.org/10.5897/JCREO2012.012
_version_ 1643710712420237312
score 13.211869

Similar Items