Cover Image

Screening For Potential Inhibitors Of Mycobacterium Tuberculosis Isocitrate Lyase: In Silico And In Vitro Approaches

Tuberculosis (TB) that is caused by Mycobacterium tuberculosis (MTB) still remains as global epidemic and affects one-third of the world population, regardless of active TB or latent TB infection. The metabolism for active and latent MTB are different, for instance they have different energy generat...

Full description

Saved in:
Bibliographic Details
Main Author: Lee , Yie Vern
Format: Thesis
Language:English
Published: 2017
Subjects:
R735-854 Medical education. Medical schools. Research
Online Access:http://eprints.usm.my/42910/1/LEE_YIE_VERN.pdf
http://eprints.usm.my/42910/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.usm.eprints.42910
record_format eprints
spelling my.usm.eprints.42910 http://eprints.usm.my/42910/ Screening For Potential Inhibitors Of Mycobacterium Tuberculosis Isocitrate Lyase: In Silico And In Vitro Approaches Lee , Yie Vern R735-854 Medical education. Medical schools. Research Tuberculosis (TB) that is caused by Mycobacterium tuberculosis (MTB) still remains as global epidemic and affects one-third of the world population, regardless of active TB or latent TB infection. The metabolism for active and latent MTB are different, for instance they have different energy generation cycle during active and latent stage. Instead of focusing on the drug targets during the active stage, which already have the effective therapeutic drugs, this study targeted isocitrate lyase (ICL), a potential target for dormant (latent) MTB energy generation cycle (glyoxylate cycle). Studies showed that without ICL, dormant MTB cannot survives within the lung of a murine model. 2017-11 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/42910/1/LEE_YIE_VERN.pdf Lee , Yie Vern (2017) Screening For Potential Inhibitors Of Mycobacterium Tuberculosis Isocitrate Lyase: In Silico And In Vitro Approaches. PhD thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic R735-854 Medical education. Medical schools. Research
spellingShingle R735-854 Medical education. Medical schools. Research
Lee , Yie Vern
Screening For Potential Inhibitors Of Mycobacterium Tuberculosis Isocitrate Lyase: In Silico And In Vitro Approaches
description Tuberculosis (TB) that is caused by Mycobacterium tuberculosis (MTB) still remains as global epidemic and affects one-third of the world population, regardless of active TB or latent TB infection. The metabolism for active and latent MTB are different, for instance they have different energy generation cycle during active and latent stage. Instead of focusing on the drug targets during the active stage, which already have the effective therapeutic drugs, this study targeted isocitrate lyase (ICL), a potential target for dormant (latent) MTB energy generation cycle (glyoxylate cycle). Studies showed that without ICL, dormant MTB cannot survives within the lung of a murine model.
format Thesis
author Lee , Yie Vern
author_facet Lee , Yie Vern
author_sort Lee , Yie Vern
title Screening For Potential Inhibitors Of Mycobacterium Tuberculosis Isocitrate Lyase: In Silico And In Vitro Approaches
title_short Screening For Potential Inhibitors Of Mycobacterium Tuberculosis Isocitrate Lyase: In Silico And In Vitro Approaches
title_full Screening For Potential Inhibitors Of Mycobacterium Tuberculosis Isocitrate Lyase: In Silico And In Vitro Approaches
title_fullStr Screening For Potential Inhibitors Of Mycobacterium Tuberculosis Isocitrate Lyase: In Silico And In Vitro Approaches
title_full_unstemmed Screening For Potential Inhibitors Of Mycobacterium Tuberculosis Isocitrate Lyase: In Silico And In Vitro Approaches
title_sort screening for potential inhibitors of mycobacterium tuberculosis isocitrate lyase: in silico and in vitro approaches
publishDate 2017
url http://eprints.usm.my/42910/1/LEE_YIE_VERN.pdf
http://eprints.usm.my/42910/
_version_ 1643710611027132416
score 13.211869

Similar Items