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Association between WOMAC score and 2D:4D ration in women with knee osteoarthritis

Introduction: The main issue in osteoarthritis is the risk of pain and physical disability. Knee osteoarthritis is one of the commonest joint disorders that lead to physical disability. Elderly women experience lower quality of life due to functional limitation and physical disability than male....

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Main Author: Amir, Nurul Fakhri
Format: Thesis
Language:English
Published: 2016
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RC Internal medicine
Online Access:http://eprints.usm.my/42541/1/Dr._Nurul_Fakhri_Amir-24_pages.pdf
http://eprints.usm.my/42541/
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spelling my.usm.eprints.42541 http://eprints.usm.my/42541/ Association between WOMAC score and 2D:4D ration in women with knee osteoarthritis Amir, Nurul Fakhri RC Internal medicine Introduction: The main issue in osteoarthritis is the risk of pain and physical disability. Knee osteoarthritis is one of the commonest joint disorders that lead to physical disability. Elderly women experience lower quality of life due to functional limitation and physical disability than male. Main factor that cause physical disability are increasing age, obesity, lack of exercise, previous knee injury and medical comorbidity. In human, finger length ratio (2D:4D) is a sexually dimorphic trait. Generally, males have low 2D:4D ratio; a ring finger that is longer than their index finger. While female typically have high or equal 2D: 4D ratio, index finger longer than ring fingers or the same length. Different digit ratio associated with human physical capability, attitude and characteristic. Previous study suggested that low 2D:4D ratio associated with higher risk to developed knee osteoarthritis in women. Objectives: To determine association between WOMAC score, Body Mass Index (BMI) with 2D:4D ratio in women with grade 2 and 3 of knee osteoarthritis. Patients and Methods: We conducted cross sectional study in 118 women with knee osteoarthritis (Kellgren Lawrence grade 2 -3), who completed the Western Ontario and McMaster Osteoarthritis Index (WOMAC) questionnaire. Length of index finger and ring finger were measured from right hand radiographs. Subjects were classified into three groups: type I (index finger longer than ring finger), type II (equal length) and type III (index finger shorter than ring finger). Body Mass Index (BMI) was measured and recorded by standard procedure.Result: The majority of the participants were classified under type III finger pattern n=56 (47%). However, this study showed there was no significant mean difference between mean total WOMAC score and each component with 2D:4D ratio. BMI correlated significantly with worse knee OA symptoms for total WOMAC score (pvalue< 0.001, r = 0.643). There was a significant association between 2D:4D ratio and Body Mass Index (BMI) (F-stat (df) 4.38 (2), P-value 0.015) and higher BMI majority in type II (mean (SD) 30.2 (4.31)). Conclusion: There is no association between WOMAC score and 2D:4D ratio in women with grade 2 and 3 of knee osteoarthritis. It means that different type of finger pattern does not affect the severity of physical disability. However, the study showed positive correlation between total WOMAC score and higher Body Mass Index (BMI) and significant association between 2D:4D ratio and higher Body Mass Index (BMI). Those with higher Body Mass Index (BMI) majority in type II 2016 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/42541/1/Dr._Nurul_Fakhri_Amir-24_pages.pdf Amir, Nurul Fakhri (2016) Association between WOMAC score and 2D:4D ration in women with knee osteoarthritis. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RC Internal medicine
spellingShingle RC Internal medicine
Amir, Nurul Fakhri
Association between WOMAC score and 2D:4D ration in women with knee osteoarthritis
description Introduction: The main issue in osteoarthritis is the risk of pain and physical disability. Knee osteoarthritis is one of the commonest joint disorders that lead to physical disability. Elderly women experience lower quality of life due to functional limitation and physical disability than male. Main factor that cause physical disability are increasing age, obesity, lack of exercise, previous knee injury and medical comorbidity. In human, finger length ratio (2D:4D) is a sexually dimorphic trait. Generally, males have low 2D:4D ratio; a ring finger that is longer than their index finger. While female typically have high or equal 2D: 4D ratio, index finger longer than ring fingers or the same length. Different digit ratio associated with human physical capability, attitude and characteristic. Previous study suggested that low 2D:4D ratio associated with higher risk to developed knee osteoarthritis in women. Objectives: To determine association between WOMAC score, Body Mass Index (BMI) with 2D:4D ratio in women with grade 2 and 3 of knee osteoarthritis. Patients and Methods: We conducted cross sectional study in 118 women with knee osteoarthritis (Kellgren Lawrence grade 2 -3), who completed the Western Ontario and McMaster Osteoarthritis Index (WOMAC) questionnaire. Length of index finger and ring finger were measured from right hand radiographs. Subjects were classified into three groups: type I (index finger longer than ring finger), type II (equal length) and type III (index finger shorter than ring finger). Body Mass Index (BMI) was measured and recorded by standard procedure.Result: The majority of the participants were classified under type III finger pattern n=56 (47%). However, this study showed there was no significant mean difference between mean total WOMAC score and each component with 2D:4D ratio. BMI correlated significantly with worse knee OA symptoms for total WOMAC score (pvalue< 0.001, r = 0.643). There was a significant association between 2D:4D ratio and Body Mass Index (BMI) (F-stat (df) 4.38 (2), P-value 0.015) and higher BMI majority in type II (mean (SD) 30.2 (4.31)). Conclusion: There is no association between WOMAC score and 2D:4D ratio in women with grade 2 and 3 of knee osteoarthritis. It means that different type of finger pattern does not affect the severity of physical disability. However, the study showed positive correlation between total WOMAC score and higher Body Mass Index (BMI) and significant association between 2D:4D ratio and higher Body Mass Index (BMI). Those with higher Body Mass Index (BMI) majority in type II
format Thesis
author Amir, Nurul Fakhri
author_facet Amir, Nurul Fakhri
author_sort Amir, Nurul Fakhri
title Association between WOMAC score and 2D:4D ration in women with knee osteoarthritis
title_short Association between WOMAC score and 2D:4D ration in women with knee osteoarthritis
title_full Association between WOMAC score and 2D:4D ration in women with knee osteoarthritis
title_fullStr Association between WOMAC score and 2D:4D ration in women with knee osteoarthritis
title_full_unstemmed Association between WOMAC score and 2D:4D ration in women with knee osteoarthritis
title_sort association between womac score and 2d:4d ration in women with knee osteoarthritis
publishDate 2016
url http://eprints.usm.my/42541/1/Dr._Nurul_Fakhri_Amir-24_pages.pdf
http://eprints.usm.my/42541/
_version_ 1643710523133394944
score 13.211869

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