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Formulation And Characterization Of Palm Oil Esters Based Nano-Cream For Topical Delivery Of Piroxicam: Study Of In Vitro Release And In Vivo Anti-Inflammatory And Analgesic Effects

During recent years, there has been increased interest in the use of topical vehicle systems that could assist drug permeation through the skin. The drugs of interest usually those causing or having problems when given orally, e.g., easily hydrolyzed in the gastro-intestinal tract, poor bioavaila...

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Main Author: Abdulkarim, Muthanna F.
Format: Thesis
Language:English
Published: 2010
Subjects:
RS1-441 Pharmacy and materia medica
Online Access:http://eprints.usm.my/42311/1/Muthanna_F._Abdulkarim24.pdf
http://eprints.usm.my/42311/
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spelling my.usm.eprints.42311 http://eprints.usm.my/42311/ Formulation And Characterization Of Palm Oil Esters Based Nano-Cream For Topical Delivery Of Piroxicam: Study Of In Vitro Release And In Vivo Anti-Inflammatory And Analgesic Effects Abdulkarim, Muthanna F. RS1-441 Pharmacy and materia medica During recent years, there has been increased interest in the use of topical vehicle systems that could assist drug permeation through the skin. The drugs of interest usually those causing or having problems when given orally, e.g., easily hydrolyzed in the gastro-intestinal tract, poor bioavailability or to cause adverse reactions. One such drug is piroxicam, a highly effective anti-inflammatory, anti-pyretic and analgesic but causes gastro-intestinal ulcers and bleeding. One of the most promising vehicle systems for trans-dermal permeation of drugs is a nano-cream, a semisolid emulsion with droplet size of 20-200 nm. The main purpose of this study is to formulate a novel nano-cream containing piroxicam for topical delivery and to use palm oil esters (POEs) a new derrivetised palm oil as the oil phase. In the initial study, pseudoternary phase diagrams of water, POEs and non-ionic surfactant mixture of several HLB values were constructed and several promising nano-cream formulae were selected. The stability under different temperatures and other properties of the formulations including the rheological behaviour, zeta potential, droplet size and structural characteristics of the formulation and Solubility and partition coeffecient of piroxicam were studied. 2010-06 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/42311/1/Muthanna_F._Abdulkarim24.pdf Abdulkarim, Muthanna F. (2010) Formulation And Characterization Of Palm Oil Esters Based Nano-Cream For Topical Delivery Of Piroxicam: Study Of In Vitro Release And In Vivo Anti-Inflammatory And Analgesic Effects. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RS1-441 Pharmacy and materia medica
spellingShingle RS1-441 Pharmacy and materia medica
Abdulkarim, Muthanna F.
Formulation And Characterization Of Palm Oil Esters Based Nano-Cream For Topical Delivery Of Piroxicam: Study Of In Vitro Release And In Vivo Anti-Inflammatory And Analgesic Effects
description During recent years, there has been increased interest in the use of topical vehicle systems that could assist drug permeation through the skin. The drugs of interest usually those causing or having problems when given orally, e.g., easily hydrolyzed in the gastro-intestinal tract, poor bioavailability or to cause adverse reactions. One such drug is piroxicam, a highly effective anti-inflammatory, anti-pyretic and analgesic but causes gastro-intestinal ulcers and bleeding. One of the most promising vehicle systems for trans-dermal permeation of drugs is a nano-cream, a semisolid emulsion with droplet size of 20-200 nm. The main purpose of this study is to formulate a novel nano-cream containing piroxicam for topical delivery and to use palm oil esters (POEs) a new derrivetised palm oil as the oil phase. In the initial study, pseudoternary phase diagrams of water, POEs and non-ionic surfactant mixture of several HLB values were constructed and several promising nano-cream formulae were selected. The stability under different temperatures and other properties of the formulations including the rheological behaviour, zeta potential, droplet size and structural characteristics of the formulation and Solubility and partition coeffecient of piroxicam were studied.
format Thesis
author Abdulkarim, Muthanna F.
author_facet Abdulkarim, Muthanna F.
author_sort Abdulkarim, Muthanna F.
title Formulation And Characterization Of Palm Oil Esters Based Nano-Cream For Topical Delivery Of Piroxicam: Study Of In Vitro Release And In Vivo Anti-Inflammatory And Analgesic Effects
title_short Formulation And Characterization Of Palm Oil Esters Based Nano-Cream For Topical Delivery Of Piroxicam: Study Of In Vitro Release And In Vivo Anti-Inflammatory And Analgesic Effects
title_full Formulation And Characterization Of Palm Oil Esters Based Nano-Cream For Topical Delivery Of Piroxicam: Study Of In Vitro Release And In Vivo Anti-Inflammatory And Analgesic Effects
title_fullStr Formulation And Characterization Of Palm Oil Esters Based Nano-Cream For Topical Delivery Of Piroxicam: Study Of In Vitro Release And In Vivo Anti-Inflammatory And Analgesic Effects
title_full_unstemmed Formulation And Characterization Of Palm Oil Esters Based Nano-Cream For Topical Delivery Of Piroxicam: Study Of In Vitro Release And In Vivo Anti-Inflammatory And Analgesic Effects
title_sort formulation and characterization of palm oil esters based nano-cream for topical delivery of piroxicam: study of in vitro release and in vivo anti-inflammatory and analgesic effects
publishDate 2010
url http://eprints.usm.my/42311/1/Muthanna_F._Abdulkarim24.pdf
http://eprints.usm.my/42311/
_version_ 1643710468889509888
score 13.211869

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