Interaction of isoniazid with Mycobacterium tuberculosis enoyl-acyl carrier protein reductase (InhA): from bioinformatics perspective.
Tuberculosis (TB), caused by Mycobacterium tuberculosis is a leading killer that has plagued mankind for centuries. The disease is estimated to infect 8 million and kill 2 - 3 million people each year (Rouse et al., 1995; Manca et al., 1997). A frequently used drug to treat TB is isonicotinic acid...
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| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Book Section |
| Language: | English |
| Published: |
Penerbit Universiti Sains Malaysia
2004
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| Subjects: | |
| Online Access: | http://eprints.usm.my/42166/1/pBIO06.pdf http://eprints.usm.my/42166/ |
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| Summary: | Tuberculosis (TB), caused by Mycobacterium tuberculosis is a leading killer that has plagued mankind for centuries. The disease is estimated to infect 8 million and kill
2 - 3 million people each year (Rouse et al., 1995; Manca et al., 1997). A frequently used drug to treat TB is isonicotinic acid hydrazide (INH/ isoniazid) but unfortunately, INHresistant M. tuberculosis organisms are
becoming quite common now. |
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