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Study On Role Of Excitatory Amino Acid Input On Rostral Ventrolateral Medulla Neurons And Assessment Of Peripheral Vascular Reactivity In Obesity-Induced Hypertension

Rostral ventrolateral medulla (RVLM) plays a pivotal role in the tonic and phasic regulation of blood pressure. The present study was carried out to determine whether the excitatory amino acid (EAA) input to the RVLM contributed to elevated blood pressure and to assess the peripheral vascular reacti...

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Main Author: Suhaimi, Farah Wahida
Format: Thesis
Language:English
Published: 2010
Subjects:
RS1-441 Pharmacy and materia medica
Online Access:http://eprints.usm.my/41231/1/Farah_Wahida_Binti_Suhaimi__HJ.pdf
http://eprints.usm.my/41231/
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spelling my.usm.eprints.41231 http://eprints.usm.my/41231/ Study On Role Of Excitatory Amino Acid Input On Rostral Ventrolateral Medulla Neurons And Assessment Of Peripheral Vascular Reactivity In Obesity-Induced Hypertension Suhaimi, Farah Wahida RS1-441 Pharmacy and materia medica Rostral ventrolateral medulla (RVLM) plays a pivotal role in the tonic and phasic regulation of blood pressure. The present study was carried out to determine whether the excitatory amino acid (EAA) input to the RVLM contributed to elevated blood pressure and to assess the peripheral vascular reactivity in obesity-induced hypertension. Male Sprague-Dawley rats were fed with low-fat diet or moderately high-fat (MHF) diet for 16 weeks. Then, rats on MHF diet were segregated into obesity-prone (OP) and obesity-resistant (OR) rats based on the body weight distribution. OR rats were defined as rats with body weight similar or less than control rats (LF rats) while OP rats were defined as rats with greatest body weight. At week 16, rats were subjected to study the role of EAA on RVLM neurons or to study the peripheral vascular reactivity in obesity-induced hypertension. In the former study, L-glutamate (1 nmol) and kynurenic acid (KYN) at concentrations of 4 nM, 40 nM and 4 μM were microinjected into RVLM and hexamethonium (20 mg/kg) was administered intravenously. Brain stem was removed for histological verification and adiposity index was calculated. OP rats exhibited significantly larger weight gain, higher adiposity index and also elevated blood pressure. 2010-10 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/41231/1/Farah_Wahida_Binti_Suhaimi__HJ.pdf Suhaimi, Farah Wahida (2010) Study On Role Of Excitatory Amino Acid Input On Rostral Ventrolateral Medulla Neurons And Assessment Of Peripheral Vascular Reactivity In Obesity-Induced Hypertension. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RS1-441 Pharmacy and materia medica
spellingShingle RS1-441 Pharmacy and materia medica
Suhaimi, Farah Wahida
Study On Role Of Excitatory Amino Acid Input On Rostral Ventrolateral Medulla Neurons And Assessment Of Peripheral Vascular Reactivity In Obesity-Induced Hypertension
description Rostral ventrolateral medulla (RVLM) plays a pivotal role in the tonic and phasic regulation of blood pressure. The present study was carried out to determine whether the excitatory amino acid (EAA) input to the RVLM contributed to elevated blood pressure and to assess the peripheral vascular reactivity in obesity-induced hypertension. Male Sprague-Dawley rats were fed with low-fat diet or moderately high-fat (MHF) diet for 16 weeks. Then, rats on MHF diet were segregated into obesity-prone (OP) and obesity-resistant (OR) rats based on the body weight distribution. OR rats were defined as rats with body weight similar or less than control rats (LF rats) while OP rats were defined as rats with greatest body weight. At week 16, rats were subjected to study the role of EAA on RVLM neurons or to study the peripheral vascular reactivity in obesity-induced hypertension. In the former study, L-glutamate (1 nmol) and kynurenic acid (KYN) at concentrations of 4 nM, 40 nM and 4 μM were microinjected into RVLM and hexamethonium (20 mg/kg) was administered intravenously. Brain stem was removed for histological verification and adiposity index was calculated. OP rats exhibited significantly larger weight gain, higher adiposity index and also elevated blood pressure.
format Thesis
author Suhaimi, Farah Wahida
author_facet Suhaimi, Farah Wahida
author_sort Suhaimi, Farah Wahida
title Study On Role Of Excitatory Amino Acid Input On Rostral Ventrolateral Medulla Neurons And Assessment Of Peripheral Vascular Reactivity In Obesity-Induced Hypertension
title_short Study On Role Of Excitatory Amino Acid Input On Rostral Ventrolateral Medulla Neurons And Assessment Of Peripheral Vascular Reactivity In Obesity-Induced Hypertension
title_full Study On Role Of Excitatory Amino Acid Input On Rostral Ventrolateral Medulla Neurons And Assessment Of Peripheral Vascular Reactivity In Obesity-Induced Hypertension
title_fullStr Study On Role Of Excitatory Amino Acid Input On Rostral Ventrolateral Medulla Neurons And Assessment Of Peripheral Vascular Reactivity In Obesity-Induced Hypertension
title_full_unstemmed Study On Role Of Excitatory Amino Acid Input On Rostral Ventrolateral Medulla Neurons And Assessment Of Peripheral Vascular Reactivity In Obesity-Induced Hypertension
title_sort study on role of excitatory amino acid input on rostral ventrolateral medulla neurons and assessment of peripheral vascular reactivity in obesity-induced hypertension
publishDate 2010
url http://eprints.usm.my/41231/1/Farah_Wahida_Binti_Suhaimi__HJ.pdf
http://eprints.usm.my/41231/
_version_ 1643710164916764672
score 13.223943

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