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MR volumetric study of cerebellum related to age ang sex

Introduction: The advancement of MRI techniques has open up many neuroanatomical studies of normal brain growth and atrophy. Numerous neurological and neuropsychiatric disorders, which can cause changes in cerebellum volumes have been identified particularly epilepsy, schizophrenia, Alzheimer’s...

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Main Author: Wan Ahmed, Wan Aireene
Format: Thesis
Language:English
Published: 2015
Subjects:
RC31-1245 Internal medicine
Online Access:http://eprints.usm.my/41085/1/Dr._Wan_Aireene_Wan_Ahmed_%28Radiology%29-24_pages.pdf
http://eprints.usm.my/41085/
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spelling my.usm.eprints.41085 http://eprints.usm.my/41085/ MR volumetric study of cerebellum related to age ang sex Wan Ahmed, Wan Aireene RC31-1245 Internal medicine Introduction: The advancement of MRI techniques has open up many neuroanatomical studies of normal brain growth and atrophy. Numerous neurological and neuropsychiatric disorders, which can cause changes in cerebellum volumes have been identified particularly epilepsy, schizophrenia, Alzheimer’s dementia, depression and autism among others. Investigations of aging effects on the cerebellum are important, not only to understand normal aging process, but also for comparative study of the pathophysiology of degenerative brain disorders. Sex differences in gross cerebellar neuroanatomy have been observed in several studies. Currently there is no normative data of MR cerebellum volumetry available for Malaysian population. Objectives: The general objective for this study is to determine the age and sex difference of the volume of cerebellum in healthy volunteers. Methods and materials: This was a cross sectional study involving 164 subjects who underwent MRI. The age of the subjects ranged from 7 to 77 years old. MRI was performed using Signa Horison LX 1.0 Tesla scanner by General Electric. MRI images were obtained in T1 sagittal sections with 5milimeter thickness with 2-millimeter gap. Cerebellum volumes were measured using manually traced slice volumetry method. The mean (SD) of total cerebellum volume was calculated and analyzed using IBM SPSS version 20. Anatomical boundaries for cerebellum volumetry done with manual tracing. Normalization of cerebellum volume with intracranial volume was done by using co-variance methods introduced by Jack et al. (1989). Manual tracing using alternate slice method was utilized in obtaining intracranial volume as described by Eritaia et al. (2000). Image display and manual tracing of the cerebellum and intracranial areas were performed using Osirix software ver.3.7.1 (Pixmeo Sarl). Data was compiled and analyzed using PASW Statistic ver.18 (SPSS Inc.). Results: The overall mean normalized cerebellar volume is 181.1 ± 24.8 cm3. When analyzed separately among gender, normalized cerebellar volume was significantly higher in male (p value= 0.035; 95% +- CI). There is a statistically significant negative correlation between age and total cerebellum volume (r is - 0.492). Cerebellar volume becomes smaller at older age with moderate to good correlation. Conclusion: The study provided a reference data of cerebellar volumes in original and normalized formats for normal Kelantan population for a valuable reference in many physiological and pathological conditions for local population. The mean normalized cerebellar volume was statistically significant in genders with larger volumes in male subjects. They also had larger intracranial volumes than female. There is significant relationship between normalized cerebellum volume with age. 2015 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/41085/1/Dr._Wan_Aireene_Wan_Ahmed_%28Radiology%29-24_pages.pdf Wan Ahmed, Wan Aireene (2015) MR volumetric study of cerebellum related to age ang sex. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RC31-1245 Internal medicine
spellingShingle RC31-1245 Internal medicine
Wan Ahmed, Wan Aireene
MR volumetric study of cerebellum related to age ang sex
description Introduction: The advancement of MRI techniques has open up many neuroanatomical studies of normal brain growth and atrophy. Numerous neurological and neuropsychiatric disorders, which can cause changes in cerebellum volumes have been identified particularly epilepsy, schizophrenia, Alzheimer’s dementia, depression and autism among others. Investigations of aging effects on the cerebellum are important, not only to understand normal aging process, but also for comparative study of the pathophysiology of degenerative brain disorders. Sex differences in gross cerebellar neuroanatomy have been observed in several studies. Currently there is no normative data of MR cerebellum volumetry available for Malaysian population. Objectives: The general objective for this study is to determine the age and sex difference of the volume of cerebellum in healthy volunteers. Methods and materials: This was a cross sectional study involving 164 subjects who underwent MRI. The age of the subjects ranged from 7 to 77 years old. MRI was performed using Signa Horison LX 1.0 Tesla scanner by General Electric. MRI images were obtained in T1 sagittal sections with 5milimeter thickness with 2-millimeter gap. Cerebellum volumes were measured using manually traced slice volumetry method. The mean (SD) of total cerebellum volume was calculated and analyzed using IBM SPSS version 20. Anatomical boundaries for cerebellum volumetry done with manual tracing. Normalization of cerebellum volume with intracranial volume was done by using co-variance methods introduced by Jack et al. (1989). Manual tracing using alternate slice method was utilized in obtaining intracranial volume as described by Eritaia et al. (2000). Image display and manual tracing of the cerebellum and intracranial areas were performed using Osirix software ver.3.7.1 (Pixmeo Sarl). Data was compiled and analyzed using PASW Statistic ver.18 (SPSS Inc.). Results: The overall mean normalized cerebellar volume is 181.1 ± 24.8 cm3. When analyzed separately among gender, normalized cerebellar volume was significantly higher in male (p value= 0.035; 95% +- CI). There is a statistically significant negative correlation between age and total cerebellum volume (r is - 0.492). Cerebellar volume becomes smaller at older age with moderate to good correlation. Conclusion: The study provided a reference data of cerebellar volumes in original and normalized formats for normal Kelantan population for a valuable reference in many physiological and pathological conditions for local population. The mean normalized cerebellar volume was statistically significant in genders with larger volumes in male subjects. They also had larger intracranial volumes than female. There is significant relationship between normalized cerebellum volume with age.
format Thesis
author Wan Ahmed, Wan Aireene
author_facet Wan Ahmed, Wan Aireene
author_sort Wan Ahmed, Wan Aireene
title MR volumetric study of cerebellum related to age ang sex
title_short MR volumetric study of cerebellum related to age ang sex
title_full MR volumetric study of cerebellum related to age ang sex
title_fullStr MR volumetric study of cerebellum related to age ang sex
title_full_unstemmed MR volumetric study of cerebellum related to age ang sex
title_sort mr volumetric study of cerebellum related to age ang sex
publishDate 2015
url http://eprints.usm.my/41085/1/Dr._Wan_Aireene_Wan_Ahmed_%28Radiology%29-24_pages.pdf
http://eprints.usm.my/41085/
_version_ 1643710124576997376
score 13.211869

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