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A study of anemia and iron deficiency in chronic systolic heart failure

Background: Iron deficiency (ID) is an emerging problem in patients with chronic systolic heart failure and can be a potential therapeutic target. However, not much is known about the frequency, predictors of iron deficiency and anemia in patients with chronic heart failure. Objectives: The prima...

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Main Author: Kok Leng, Tan
Format: Thesis
Language:English
Published: 2014
Subjects:
RC666-701 Diseases of the circulatory (Cardiovascular) system
Online Access:http://eprints.usm.my/39461/1/Dr_Tan_Kok_Leng_%28_Internal_Medicine_%29-24_pages.pdf
http://eprints.usm.my/39461/
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spelling my.usm.eprints.39461 http://eprints.usm.my/39461/ A study of anemia and iron deficiency in chronic systolic heart failure Kok Leng, Tan RC666-701 Diseases of the circulatory (Cardiovascular) system Background: Iron deficiency (ID) is an emerging problem in patients with chronic systolic heart failure and can be a potential therapeutic target. However, not much is known about the frequency, predictors of iron deficiency and anemia in patients with chronic heart failure. Objectives: The primary objective of this study was to determine the frequency of iron deficiency in chronic systolic heart failure patients who were follow up in Hospital Universiti Sains Malaysia. The secondary objectives included were to determine the frequency of anemia in the same study population, correlation between ejection fraction and blood parameters and determining risk factors for anemia in chronic systolic heart failure. Methods: A total of 81 patients who were followed up in Hospital Universiti Sains Malaysia were recruited into this cross sectional study using purposive sampling method. These patients had history of chronic systolic heart failure for more than 6 months with left ventricular ejection fraction less than 45% as assessed by echocardiography using Simpson’s planimetric method. 10mls of venous blood was drawn from each participant and analyzed. Results: Thirty three patients were anemic (40.7%) as compared to 48 patients (59.3%) who did not. Sixteen patients were iron deficient (19.8%). All iron deficiency patients were anemic patients. There were positive correlation between serum ferritin (r=0.624, p<0.001), transferrin saturation (r= 0.346, p<0.001) and hemoglobin (r=0.528, p<0.001) with ejection fraction, respectively. Anemia in chronic systolic heart failure was independently associated with serum ferritin (OR 0.974, 95% CI 0.959, 0.988), transferrin saturation (OR 0.831, 95% CI 0.726, 0.952), and diabetes mellitus (OR 6.680, 95% CI 1.599, 27.897) based on multiple logistic regression analysis. Conclusion: This study demonstrated high frequency of anemia in chronic systolic heart failure patients. Majority of anemic patients were iron deficient. Besides that, serum hemoglobin and serum ferritin and transferrin saturation were positively correlated with left ventricular ejection fraction. It is recommended in future, an appropriately powered randomized trials with correction of anemia using erythropoietin and intravenous iron be carried out to validate the study findings. 2014 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/39461/1/Dr_Tan_Kok_Leng_%28_Internal_Medicine_%29-24_pages.pdf Kok Leng, Tan (2014) A study of anemia and iron deficiency in chronic systolic heart failure. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RC666-701 Diseases of the circulatory (Cardiovascular) system
spellingShingle RC666-701 Diseases of the circulatory (Cardiovascular) system
Kok Leng, Tan
A study of anemia and iron deficiency in chronic systolic heart failure
description Background: Iron deficiency (ID) is an emerging problem in patients with chronic systolic heart failure and can be a potential therapeutic target. However, not much is known about the frequency, predictors of iron deficiency and anemia in patients with chronic heart failure. Objectives: The primary objective of this study was to determine the frequency of iron deficiency in chronic systolic heart failure patients who were follow up in Hospital Universiti Sains Malaysia. The secondary objectives included were to determine the frequency of anemia in the same study population, correlation between ejection fraction and blood parameters and determining risk factors for anemia in chronic systolic heart failure. Methods: A total of 81 patients who were followed up in Hospital Universiti Sains Malaysia were recruited into this cross sectional study using purposive sampling method. These patients had history of chronic systolic heart failure for more than 6 months with left ventricular ejection fraction less than 45% as assessed by echocardiography using Simpson’s planimetric method. 10mls of venous blood was drawn from each participant and analyzed. Results: Thirty three patients were anemic (40.7%) as compared to 48 patients (59.3%) who did not. Sixteen patients were iron deficient (19.8%). All iron deficiency patients were anemic patients. There were positive correlation between serum ferritin (r=0.624, p<0.001), transferrin saturation (r= 0.346, p<0.001) and hemoglobin (r=0.528, p<0.001) with ejection fraction, respectively. Anemia in chronic systolic heart failure was independently associated with serum ferritin (OR 0.974, 95% CI 0.959, 0.988), transferrin saturation (OR 0.831, 95% CI 0.726, 0.952), and diabetes mellitus (OR 6.680, 95% CI 1.599, 27.897) based on multiple logistic regression analysis. Conclusion: This study demonstrated high frequency of anemia in chronic systolic heart failure patients. Majority of anemic patients were iron deficient. Besides that, serum hemoglobin and serum ferritin and transferrin saturation were positively correlated with left ventricular ejection fraction. It is recommended in future, an appropriately powered randomized trials with correction of anemia using erythropoietin and intravenous iron be carried out to validate the study findings.
format Thesis
author Kok Leng, Tan
author_facet Kok Leng, Tan
author_sort Kok Leng, Tan
title A study of anemia and iron deficiency in chronic systolic heart failure
title_short A study of anemia and iron deficiency in chronic systolic heart failure
title_full A study of anemia and iron deficiency in chronic systolic heart failure
title_fullStr A study of anemia and iron deficiency in chronic systolic heart failure
title_full_unstemmed A study of anemia and iron deficiency in chronic systolic heart failure
title_sort study of anemia and iron deficiency in chronic systolic heart failure
publishDate 2014
url http://eprints.usm.my/39461/1/Dr_Tan_Kok_Leng_%28_Internal_Medicine_%29-24_pages.pdf
http://eprints.usm.my/39461/
_version_ 1643709658308804608
score 13.211869

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