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Effect of surfactant and surfactant blends on pseudoternary phase diagram behavior of newly synthesized palm kernel oil esters

Background: The purpose of this study was to select appropriate surfactants or blends of surfactants to study the ternary phase diagram behavior of newly introduced palm kernel oil esters. Methods: Nonionic surfactant blends of Tween® and Tween®/Span® series were screened based on their solubili...

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Main Authors: Elrashid, Saleh Mahdi, Mohamed HF, Sakeena, Muthanna F, Abdulkarim, Ghassan Z, Abdullah, Munavvar, Abdul Sattar, Azmin, Mohd Noor
Format: Article
Language:English
Published: Dove Medical Press 2011
Subjects:
RS1-441 Pharmacy and materia medica
Online Access:http://eprints.usm.my/38886/1/Effect_of_surfactant_and_surfactant_blends_on_pseudoternary_phase_diagram_behavior.pdf
http://eprints.usm.my/38886/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140288/
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spelling my.usm.eprints.38886 http://eprints.usm.my/38886/ Effect of surfactant and surfactant blends on pseudoternary phase diagram behavior of newly synthesized palm kernel oil esters Elrashid, Saleh Mahdi Mohamed HF, Sakeena Muthanna F, Abdulkarim Ghassan Z, Abdullah Munavvar, Abdul Sattar Azmin, Mohd Noor RS1-441 Pharmacy and materia medica Background: The purpose of this study was to select appropriate surfactants or blends of surfactants to study the ternary phase diagram behavior of newly introduced palm kernel oil esters. Methods: Nonionic surfactant blends of Tween® and Tween®/Span® series were screened based on their solubilization capacity with water for palm kernel oil esters. Tween® 80 and five blends of Tween® 80/Span® 80 and Tween® 80/Span® 85 in the hydrophilic-lipophilic balance (HLB) value range of 10.7–14.0 were selected to study the phase diagram behavior of palm kernel oil esters using the water titration method at room temperature. Results: High solubilization capacity was obtained by Tween® 80 compared with other surfactants of Tween® series. High HLB blends of Tween® 80/Span® 85 and Tween® 80/Span® 80 at HLB 13.7 and 13.9, respectively, have better solubilization capacity compared with the lower HLB values of Tween® 80/Span® 80. All the selected blends of surfactants were formed as waterin- oil microemulsions, and other dispersion systems varied in size and geometrical layout in the triangles. The high solubilization capacity and larger areas of the water-in-oil microemulsion systems were due to the structural similarity between the lipophilic tail of Tween® 80 and the oleyl group of the palm kernel oil esters. Conclusion: This study suggests that the phase diagram behavior of palm kernel oil esters, water, and nonionic surfactants is not only affected by the HLB value, but also by the structural similarity between palm kernel oil esters and the surfactant used. The information gathered in this study is useful for researchers and manufacturers interested in using palm kernel oil esters in pharmaceutical and cosmetic preparation. The use of palm kernel oil esters can improve drug delivery and reduce the cost of cosmetics. Dove Medical Press 2011 Article PeerReviewed application/pdf en http://eprints.usm.my/38886/1/Effect_of_surfactant_and_surfactant_blends_on_pseudoternary_phase_diagram_behavior.pdf Elrashid, Saleh Mahdi and Mohamed HF, Sakeena and Muthanna F, Abdulkarim and Ghassan Z, Abdullah and Munavvar, Abdul Sattar and Azmin, Mohd Noor (2011) Effect of surfactant and surfactant blends on pseudoternary phase diagram behavior of newly synthesized palm kernel oil esters. Drug Design, Development and Therapy, 2011 (5). pp. 311-323. ISSN 1177-8881 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140288/
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RS1-441 Pharmacy and materia medica
spellingShingle RS1-441 Pharmacy and materia medica
Elrashid, Saleh Mahdi
Mohamed HF, Sakeena
Muthanna F, Abdulkarim
Ghassan Z, Abdullah
Munavvar, Abdul Sattar
Azmin, Mohd Noor
Effect of surfactant and surfactant blends on pseudoternary phase diagram behavior of newly synthesized palm kernel oil esters
description Background: The purpose of this study was to select appropriate surfactants or blends of surfactants to study the ternary phase diagram behavior of newly introduced palm kernel oil esters. Methods: Nonionic surfactant blends of Tween® and Tween®/Span® series were screened based on their solubilization capacity with water for palm kernel oil esters. Tween® 80 and five blends of Tween® 80/Span® 80 and Tween® 80/Span® 85 in the hydrophilic-lipophilic balance (HLB) value range of 10.7–14.0 were selected to study the phase diagram behavior of palm kernel oil esters using the water titration method at room temperature. Results: High solubilization capacity was obtained by Tween® 80 compared with other surfactants of Tween® series. High HLB blends of Tween® 80/Span® 85 and Tween® 80/Span® 80 at HLB 13.7 and 13.9, respectively, have better solubilization capacity compared with the lower HLB values of Tween® 80/Span® 80. All the selected blends of surfactants were formed as waterin- oil microemulsions, and other dispersion systems varied in size and geometrical layout in the triangles. The high solubilization capacity and larger areas of the water-in-oil microemulsion systems were due to the structural similarity between the lipophilic tail of Tween® 80 and the oleyl group of the palm kernel oil esters. Conclusion: This study suggests that the phase diagram behavior of palm kernel oil esters, water, and nonionic surfactants is not only affected by the HLB value, but also by the structural similarity between palm kernel oil esters and the surfactant used. The information gathered in this study is useful for researchers and manufacturers interested in using palm kernel oil esters in pharmaceutical and cosmetic preparation. The use of palm kernel oil esters can improve drug delivery and reduce the cost of cosmetics.
format Article
author Elrashid, Saleh Mahdi
Mohamed HF, Sakeena
Muthanna F, Abdulkarim
Ghassan Z, Abdullah
Munavvar, Abdul Sattar
Azmin, Mohd Noor
author_facet Elrashid, Saleh Mahdi
Mohamed HF, Sakeena
Muthanna F, Abdulkarim
Ghassan Z, Abdullah
Munavvar, Abdul Sattar
Azmin, Mohd Noor
author_sort Elrashid, Saleh Mahdi
title Effect of surfactant and surfactant blends on pseudoternary phase diagram behavior of newly synthesized palm kernel oil esters
title_short Effect of surfactant and surfactant blends on pseudoternary phase diagram behavior of newly synthesized palm kernel oil esters
title_full Effect of surfactant and surfactant blends on pseudoternary phase diagram behavior of newly synthesized palm kernel oil esters
title_fullStr Effect of surfactant and surfactant blends on pseudoternary phase diagram behavior of newly synthesized palm kernel oil esters
title_full_unstemmed Effect of surfactant and surfactant blends on pseudoternary phase diagram behavior of newly synthesized palm kernel oil esters
title_sort effect of surfactant and surfactant blends on pseudoternary phase diagram behavior of newly synthesized palm kernel oil esters
publisher Dove Medical Press
publishDate 2011
url http://eprints.usm.my/38886/1/Effect_of_surfactant_and_surfactant_blends_on_pseudoternary_phase_diagram_behavior.pdf
http://eprints.usm.my/38886/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140288/
_version_ 1643709489124212736
score 13.211869

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