Dietary Phytochemicals: Natural Swords Combating Inflammation and Oxidation-Mediated Degenerative Diseases
Cumulatively, degenerative disease is one of themost fatal groups of diseases, and it contributes to themortality and poor quality of life in the world while increasing the economic burden of the sufferers. Oxidative stress and inflammation are the major pathogenic causes of degenerative diseases...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Publishing Corporation
2016
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| Subjects: | |
| Online Access: | http://eprints.usm.my/38692/1/Dietary_Phytochemicals_Natural_Swords_Combating_Inflammation.pdf http://eprints.usm.my/38692/ http://dx.doi.org/10.1155/2016/5137431 |
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| Summary: | Cumulatively, degenerative disease is one of themost fatal groups of diseases, and it contributes to themortality and poor quality of
life in the world while increasing the economic burden of the sufferers. Oxidative stress and inflammation are the major pathogenic
causes of degenerative diseases such as rheumatoid arthritis (RA), diabetes mellitus (DM), and cardiovascular disease (CVD).
Although a number of synthetic medications are used to treat these diseases, none of the current regimens are completely safe.
Phytochemicals (polyphenols, carotenoids, anthocyanins, alkaloids, glycosides, saponins, and terpenes) from natural products
such as dietary fruits, vegetables, and spices are potential sources of alternative medications to attenuate the oxidative stress and
inflammation associated with degenerative diseases. Based on in vitro, in vivo, and clinical trials, some of these active compounds
have shown good promise for development into novel agents for treating RA, DM, and CVD by targeting oxidative stress and
inflammation. In this review, phytochemicals from natural products with the potential of ameliorating degenerative disease
involving the bone, metabolism, and the heart are described. |
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