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Assessment of the Optic Nerve Head Parameters Using Heidelberg Retinal Tomography III in Preterm Children

Background: Variations in optic nerve head morphology and abnormal retinal vascular pattern have been described in preterm children using digital image analysis of fundus photograph, optical coherence tomograph and serial funduscopy. We aimed to compare the optic nerve head parameters in preterm a...

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Main Authors: Salem, Alshaarawi, Ismail, Shatriah, Embong, Zunaina, Wan Hitam, Wan Hazabbah
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014
Subjects:
RE Ophthalmology
Online Access:http://eprints.usm.my/38369/1/Assessment_of_the_Optic_Nerve_Head_Parameters_Using.pdf
http://eprints.usm.my/38369/
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088056#s3
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spelling my.usm.eprints.38369 http://eprints.usm.my/38369/ Assessment of the Optic Nerve Head Parameters Using Heidelberg Retinal Tomography III in Preterm Children Salem, Alshaarawi Ismail, Shatriah Embong, Zunaina Wan Hitam, Wan Hazabbah RE Ophthalmology Background: Variations in optic nerve head morphology and abnormal retinal vascular pattern have been described in preterm children using digital image analysis of fundus photograph, optical coherence tomograph and serial funduscopy. We aimed to compare the optic nerve head parameters in preterm and term Malay children using Heidelberg Retinal Tomograph III. Design: A cross sectional study. Methodology/Principal Findings: Thirty-two preterm Malay children who were born at up to 32 weeks postconception, and 32 term Malay children aged 8–16 years old were recruited into this cross sectional study, which was conducted in the Hospital Universiti Sains Malaysia, Malaysia from January to December 2011. Their optic nerves were scanned and analyzed using a Heidelberg Retinal Tomography (HRT) III (Heidelberg Engineering, Germany). Preterm children showed an increased rim volume (SD) (0.56 (0.26) vs 0.44 (0.18) mm3, respectively), smaller cup shape (SD) (0.18 (0.07) vs 0.25 (0.06) mm, respectively), increased height variation contour (SD) (0.44 (0.14) vs 0.35 (0.08) mm, respectively), and increased cup depth (SD) (0.24 (0.11) vs 0.17 (0.05) mm3, respectively) when compared to their normal peers (p,0.05). There were no significant differences in the mean disc area, cup area, cup to disc ratio or rim area between the preterm and term children (p.0.05) in our study. Conclusions/Significance: Preterm children exhibit different characteristics of optic nerve head parameters with HRT III analysis. Increased cup depth in preterm children suggests a need for close observation and monitoring. It may raise suspicion of pediatric glaucoma when proper documentation of intraocular pressure and clinical funduscopy are unsuccessful in uncooperative children. Public Library of Science (PLoS) 2014-02 Article PeerReviewed application/pdf en http://eprints.usm.my/38369/1/Assessment_of_the_Optic_Nerve_Head_Parameters_Using.pdf Salem, Alshaarawi and Ismail, Shatriah and Embong, Zunaina and Wan Hitam, Wan Hazabbah (2014) Assessment of the Optic Nerve Head Parameters Using Heidelberg Retinal Tomography III in Preterm Children. PLoS ONE, 9 (2). pp. 1-5. ISSN 1932-6203 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088056#s3
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RE Ophthalmology
spellingShingle RE Ophthalmology
Salem, Alshaarawi
Ismail, Shatriah
Embong, Zunaina
Wan Hitam, Wan Hazabbah
Assessment of the Optic Nerve Head Parameters Using Heidelberg Retinal Tomography III in Preterm Children
description Background: Variations in optic nerve head morphology and abnormal retinal vascular pattern have been described in preterm children using digital image analysis of fundus photograph, optical coherence tomograph and serial funduscopy. We aimed to compare the optic nerve head parameters in preterm and term Malay children using Heidelberg Retinal Tomograph III. Design: A cross sectional study. Methodology/Principal Findings: Thirty-two preterm Malay children who were born at up to 32 weeks postconception, and 32 term Malay children aged 8–16 years old were recruited into this cross sectional study, which was conducted in the Hospital Universiti Sains Malaysia, Malaysia from January to December 2011. Their optic nerves were scanned and analyzed using a Heidelberg Retinal Tomography (HRT) III (Heidelberg Engineering, Germany). Preterm children showed an increased rim volume (SD) (0.56 (0.26) vs 0.44 (0.18) mm3, respectively), smaller cup shape (SD) (0.18 (0.07) vs 0.25 (0.06) mm, respectively), increased height variation contour (SD) (0.44 (0.14) vs 0.35 (0.08) mm, respectively), and increased cup depth (SD) (0.24 (0.11) vs 0.17 (0.05) mm3, respectively) when compared to their normal peers (p,0.05). There were no significant differences in the mean disc area, cup area, cup to disc ratio or rim area between the preterm and term children (p.0.05) in our study. Conclusions/Significance: Preterm children exhibit different characteristics of optic nerve head parameters with HRT III analysis. Increased cup depth in preterm children suggests a need for close observation and monitoring. It may raise suspicion of pediatric glaucoma when proper documentation of intraocular pressure and clinical funduscopy are unsuccessful in uncooperative children.
format Article
author Salem, Alshaarawi
Ismail, Shatriah
Embong, Zunaina
Wan Hitam, Wan Hazabbah
author_facet Salem, Alshaarawi
Ismail, Shatriah
Embong, Zunaina
Wan Hitam, Wan Hazabbah
author_sort Salem, Alshaarawi
title Assessment of the Optic Nerve Head Parameters Using Heidelberg Retinal Tomography III in Preterm Children
title_short Assessment of the Optic Nerve Head Parameters Using Heidelberg Retinal Tomography III in Preterm Children
title_full Assessment of the Optic Nerve Head Parameters Using Heidelberg Retinal Tomography III in Preterm Children
title_fullStr Assessment of the Optic Nerve Head Parameters Using Heidelberg Retinal Tomography III in Preterm Children
title_full_unstemmed Assessment of the Optic Nerve Head Parameters Using Heidelberg Retinal Tomography III in Preterm Children
title_sort assessment of the optic nerve head parameters using heidelberg retinal tomography iii in preterm children
publisher Public Library of Science (PLoS)
publishDate 2014
url http://eprints.usm.my/38369/1/Assessment_of_the_Optic_Nerve_Head_Parameters_Using.pdf
http://eprints.usm.my/38369/
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088056#s3
_version_ 1643709337048186880
score 13.222552

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