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Antimicrobial Activity of Artemisinin and Precursor Derived from In Vitro Plantlets of Artemisia annua L.

Artemisia annua L., a medicinal herb, produces secondary metabolites with antimicrobial property. InMalaysia due to the tropical hot climate, A. annua could not be planted for production of artemisinin, themain bioactive compound. In this study, the leaves of three in vitro A. annua L. clones were...

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Main Authors:	Appalasamy, Suganthi, Kiah, Yann Lo, Song, Jin Ch’ng, Ku Nornadia, Ku Nornadia, Othman, Ahmad Sofiman, Chan, Lai Keng
Format:	Article
Language:	English
Published:	Hindawi Publishing Corporation 2014
Subjects:	QH1 Natural history (General - Including nature conservation, geographical distribution)
Online Access:	http://eprints.usm.my/38335/1/Antimicrobial_Activity_of_Artemisinin_and_Precursor_Derived_from_In_Vitro_Plantlets_of.pdf http://eprints.usm.my/38335/ http://dx.doi.org/10.1155/2014/215872
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id	my.usm.eprints.38335
record_format	eprints
spelling	my.usm.eprints.38335 http://eprints.usm.my/38335/ Antimicrobial Activity of Artemisinin and Precursor Derived from In Vitro Plantlets of Artemisia annua L. Appalasamy, Suganthi Kiah, Yann Lo Song, Jin Ch’ng Ku Nornadia, Ku Nornadia Othman, Ahmad Sofiman Chan, Lai Keng QH1 Natural history (General - Including nature conservation, geographical distribution) Artemisia annua L., a medicinal herb, produces secondary metabolites with antimicrobial property. InMalaysia due to the tropical hot climate, A. annua could not be planted for production of artemisinin, themain bioactive compound. In this study, the leaves of three in vitro A. annua L. clones were, extracted and two bioactive compounds, artemisinin and a precursor, were isolated by thin layer chromatography. These compounds were found to be effective in inhibiting the growth of Gram-positive and Gram-negative bacteria but not Candida albicans.Their antimicrobial activity was similar to that of antibactericidal antibiotic streptomycin. They were found to inhibit the growth of the tested microbes at the minimum inhibition concentration of 0.09mg/mL, and toxicity test using brine shrimp showed that even the low concentration of 0.09mg/mL was very lethal towards the brine shrimps with 100% mortality rate. This study hence indicated that in vitro cultured plantlets of A. annua can be used as the alternative method for production of artemisinin and its precursor with antimicrobial activities. Hindawi Publishing Corporation 2014 Article PeerReviewed application/pdf en http://eprints.usm.my/38335/1/Antimicrobial_Activity_of_Artemisinin_and_Precursor_Derived_from_In_Vitro_Plantlets_of.pdf Appalasamy, Suganthi and Kiah, Yann Lo and Song, Jin Ch’ng and Ku Nornadia, Ku Nornadia and Othman, Ahmad Sofiman and Chan, Lai Keng (2014) Antimicrobial Activity of Artemisinin and Precursor Derived from In Vitro Plantlets of Artemisia annua L. BioMed Research International, 2014 (215872). pp. 1-6. ISSN 2314-6133 http://dx.doi.org/10.1155/2014/215872
institution	Universiti Sains Malaysia
building	Hamzah Sendut Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Sains Malaysia
content_source	USM Institutional Repository
url_provider	http://eprints.usm.my/
language	English
topic	QH1 Natural history (General - Including nature conservation, geographical distribution)
spellingShingle	QH1 Natural history (General - Including nature conservation, geographical distribution) Appalasamy, Suganthi Kiah, Yann Lo Song, Jin Ch’ng Ku Nornadia, Ku Nornadia Othman, Ahmad Sofiman Chan, Lai Keng Antimicrobial Activity of Artemisinin and Precursor Derived from In Vitro Plantlets of Artemisia annua L.
description	Artemisia annua L., a medicinal herb, produces secondary metabolites with antimicrobial property. InMalaysia due to the tropical hot climate, A. annua could not be planted for production of artemisinin, themain bioactive compound. In this study, the leaves of three in vitro A. annua L. clones were, extracted and two bioactive compounds, artemisinin and a precursor, were isolated by thin layer chromatography. These compounds were found to be effective in inhibiting the growth of Gram-positive and Gram-negative bacteria but not Candida albicans.Their antimicrobial activity was similar to that of antibactericidal antibiotic streptomycin. They were found to inhibit the growth of the tested microbes at the minimum inhibition concentration of 0.09mg/mL, and toxicity test using brine shrimp showed that even the low concentration of 0.09mg/mL was very lethal towards the brine shrimps with 100% mortality rate. This study hence indicated that in vitro cultured plantlets of A. annua can be used as the alternative method for production of artemisinin and its precursor with antimicrobial activities.
format	Article
author	Appalasamy, Suganthi Kiah, Yann Lo Song, Jin Ch’ng Ku Nornadia, Ku Nornadia Othman, Ahmad Sofiman Chan, Lai Keng
author_facet	Appalasamy, Suganthi Kiah, Yann Lo Song, Jin Ch’ng Ku Nornadia, Ku Nornadia Othman, Ahmad Sofiman Chan, Lai Keng
author_sort	Appalasamy, Suganthi
title	Antimicrobial Activity of Artemisinin and Precursor Derived from In Vitro Plantlets of Artemisia annua L.
title_short	Antimicrobial Activity of Artemisinin and Precursor Derived from In Vitro Plantlets of Artemisia annua L.
title_full	Antimicrobial Activity of Artemisinin and Precursor Derived from In Vitro Plantlets of Artemisia annua L.
title_fullStr	Antimicrobial Activity of Artemisinin and Precursor Derived from In Vitro Plantlets of Artemisia annua L.
title_full_unstemmed	Antimicrobial Activity of Artemisinin and Precursor Derived from In Vitro Plantlets of Artemisia annua L.
title_sort	antimicrobial activity of artemisinin and precursor derived from in vitro plantlets of artemisia annua l.
publisher	Hindawi Publishing Corporation
publishDate	2014
url	http://eprints.usm.my/38335/1/Antimicrobial_Activity_of_Artemisinin_and_Precursor_Derived_from_In_Vitro_Plantlets_of.pdf http://eprints.usm.my/38335/ http://dx.doi.org/10.1155/2014/215872
_version_	1643709327258681344
score	13.211869

Antimicrobial Activity of Artemisinin and Precursor Derived from In Vitro Plantlets of Artemisia annua L.

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