The potential of standardized quassinoid-rich extract of Eurycoma longifolia in the regulation of the oestrous cycle of rats
Objective: To evaluate the effects of Eurycoma longifolia (E. longifolia) standardized extract on the oestrous cycle, levels of reproductive hormones and histology of the ovaries of Sprague-Dawley rats. Methods: Female rats were orally treated with E. longifolia standardized extract at the dose...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Published: |
Elsevier
2017
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| Subjects: | |
| Online Access: | http://eprints.usm.my/37262/ http://dx.doi.org/10.1016/j.apjtb.2016.07.016 |
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| Summary: | Objective: To evaluate the effects of Eurycoma longifolia (E. longifolia) standardized
extract on the oestrous cycle, levels of reproductive hormones and histology of the
ovaries of Sprague-Dawley rats.
Methods: Female rats were orally treated with E. longifolia standardized extract at the
dose levels of 2.5, 5.0, 10.0, 25.0, 50.0 and 100.0 mg/kg of body weight over 5 days.
Vaginal smears were monitored daily within the duration and after withdrawal of the
treatment before being sacrificed. The body weights of the females were recorded before
and after the 5 days treatment. At the end of the experiments, blood samples were
collected for determination of testosterone, oestradiol and progesterone levels. Ovaries
were removed, weighed and examined for histomorphological changes.
Results: The administration of E. longifolia standardized extract did not significantly
alter the oestrous cycle of the rats during the 5 days treatment and after withdrawal of the
treatments. This was supported by normal testosterone, oestradiol and progesterone levels
as well as normal morphology of the ovaries.
Conclusions: The data obtained showed that E. longifolia standardized extract did not
exhibit any toxic effect on reproductive activities of female rats suggesting potential use
in the management of infertility. |
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