Staff View: Current and Potential Developments of Cortisol Aptasensing towards Point-of-Care Diagnostics (POTC)

Current and Potential Developments of Cortisol Aptasensing towards Point-of-Care Diagnostics (POTC)

Anxiety is a psychological problem that often emerges during the normal course of human life. The detection of anxiety often involves a physical exam and a self-reporting questionnaire. However, these approaches have limitations, as the data might lack reliability and consistency upon application...

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Main Authors:	Zainol Abidin, Azrul Syafiq, A. Rahim, Ruslinda, Md Arshad, Mohd Khairuddin, Mohd Faudzi, Fatin Nabilah, Chun, Hong Voon, Tang, Thean Hock, Marimuthu, Citartan
Format:	Article
Language:	English
Published:	MDPI 2017
Subjects:	RK1-715 Dentistry
Online Access:	http://eprints.usm.my/36884/1/%28Current_and_Potential_Developments%29__sensors-17-01180.pdf http://eprints.usm.my/36884/ http://www.mdpi.com/1424-8220/17/5/1180
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id	my.usm.eprints.36884
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spelling	my.usm.eprints.36884 http://eprints.usm.my/36884/ Current and Potential Developments of Cortisol Aptasensing towards Point-of-Care Diagnostics (POTC) Zainol Abidin, Azrul Syafiq A. Rahim, Ruslinda Md Arshad, Mohd Khairuddin Mohd Faudzi, Fatin Nabilah Chun, Hong Voon Tang, Thean Hock Marimuthu, Citartan RK1-715 Dentistry Anxiety is a psychological problem that often emerges during the normal course of human life. The detection of anxiety often involves a physical exam and a self-reporting questionnaire. However, these approaches have limitations, as the data might lack reliability and consistency upon application to the same population over time. Furthermore, there might be varying understanding and interpretations of the particular question by the participant, which necessitating the approach of using biomarker-based measurement for stress diagnosis. The most prominent biomarker related to stress, hormone cortisol, plays a key role in the fight-or-flight situation, alters the immune response, and suppresses the digestive and the reproductive systems. We have taken the endeavour to review the available aptamer-based biosensor (aptasensor) for cortisol detection. The potential point-of-care diagnostic strategies that could be harnessed for the aptasensing of cortisol were also envisaged. MDPI 2017 Article PeerReviewed application/pdf en http://eprints.usm.my/36884/1/%28Current_and_Potential_Developments%29__sensors-17-01180.pdf Zainol Abidin, Azrul Syafiq and A. Rahim, Ruslinda and Md Arshad, Mohd Khairuddin and Mohd Faudzi, Fatin Nabilah and Chun, Hong Voon and Tang, Thean Hock and Marimuthu, Citartan (2017) Current and Potential Developments of Cortisol Aptasensing towards Point-of-Care Diagnostics (POTC). Sensors, 17 (1180). pp. 1-13. ISSN 1424-8220 http://www.mdpi.com/1424-8220/17/5/1180
institution	Universiti Sains Malaysia
building	Hamzah Sendut Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Sains Malaysia
content_source	USM Institutional Repository
url_provider	http://eprints.usm.my/
language	English
topic	RK1-715 Dentistry
spellingShingle	RK1-715 Dentistry Zainol Abidin, Azrul Syafiq A. Rahim, Ruslinda Md Arshad, Mohd Khairuddin Mohd Faudzi, Fatin Nabilah Chun, Hong Voon Tang, Thean Hock Marimuthu, Citartan Current and Potential Developments of Cortisol Aptasensing towards Point-of-Care Diagnostics (POTC)
description	Anxiety is a psychological problem that often emerges during the normal course of human life. The detection of anxiety often involves a physical exam and a self-reporting questionnaire. However, these approaches have limitations, as the data might lack reliability and consistency upon application to the same population over time. Furthermore, there might be varying understanding and interpretations of the particular question by the participant, which necessitating the approach of using biomarker-based measurement for stress diagnosis. The most prominent biomarker related to stress, hormone cortisol, plays a key role in the fight-or-flight situation, alters the immune response, and suppresses the digestive and the reproductive systems. We have taken the endeavour to review the available aptamer-based biosensor (aptasensor) for cortisol detection. The potential point-of-care diagnostic strategies that could be harnessed for the aptasensing of cortisol were also envisaged.
format	Article
author	Zainol Abidin, Azrul Syafiq A. Rahim, Ruslinda Md Arshad, Mohd Khairuddin Mohd Faudzi, Fatin Nabilah Chun, Hong Voon Tang, Thean Hock Marimuthu, Citartan
author_facet	Zainol Abidin, Azrul Syafiq A. Rahim, Ruslinda Md Arshad, Mohd Khairuddin Mohd Faudzi, Fatin Nabilah Chun, Hong Voon Tang, Thean Hock Marimuthu, Citartan
author_sort	Zainol Abidin, Azrul Syafiq
title	Current and Potential Developments of Cortisol Aptasensing towards Point-of-Care Diagnostics (POTC)
title_short	Current and Potential Developments of Cortisol Aptasensing towards Point-of-Care Diagnostics (POTC)
title_full	Current and Potential Developments of Cortisol Aptasensing towards Point-of-Care Diagnostics (POTC)
title_fullStr	Current and Potential Developments of Cortisol Aptasensing towards Point-of-Care Diagnostics (POTC)
title_full_unstemmed	Current and Potential Developments of Cortisol Aptasensing towards Point-of-Care Diagnostics (POTC)
title_sort	current and potential developments of cortisol aptasensing towards point-of-care diagnostics (potc)
publisher	MDPI
publishDate	2017
url	http://eprints.usm.my/36884/1/%28Current_and_Potential_Developments%29__sensors-17-01180.pdf http://eprints.usm.my/36884/ http://www.mdpi.com/1424-8220/17/5/1180
_version_	1643708912320380928
score	13.211869

Current and Potential Developments of Cortisol Aptasensing towards Point-of-Care Diagnostics (POTC)

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