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Effects of the mGluR5 antagonist MPEP on ethanol withdrawal induced anxiety-like syndrome in rats

Abstinence from chronic ethanol consumption leads to the manifestation of a variety of symptoms attributed to central nervous system hyperexcitability, such as increased irritability, anxiety, and restlessness. Recent studies have demonstrated the importance of metabotropic glutamate receptor 5 (m...

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Main Authors: Kumar, Jaya, Hapidin, Hermizi, Get Bee, Yvonne-Tee, Ismail, Zalina
Format: Article
Language:English
Published: 2013
Subjects:
RA0421 Public health. Hygiene. Preventive Medicine
Online Access:http://eprints.usm.my/35805/1/Kumar_et_al_BBF_2013.pdf
http://eprints.usm.my/35805/
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spelling my.usm.eprints.35805 http://eprints.usm.my/35805/ Effects of the mGluR5 antagonist MPEP on ethanol withdrawal induced anxiety-like syndrome in rats Kumar, Jaya Hapidin, Hermizi Get Bee, Yvonne-Tee Ismail, Zalina RA0421 Public health. Hygiene. Preventive Medicine Abstinence from chronic ethanol consumption leads to the manifestation of a variety of symptoms attributed to central nervous system hyperexcitability, such as increased irritability, anxiety, and restlessness. Recent studies have demonstrated the importance of metabotropic glutamate receptor 5 (mGluR5) in addictive behaviours. This study investigates the effects of the mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) on ethanol withdrawal induced anxiety using two behavioural paradigms. Male Wistar rats were fed a Modified Liquid Diet (MLD) containing low fat cow milk, sucrose, and maltodextrin with a gradual introduction of 2.4%, 4.8% and 7.2% ethanol for 20 days. Six hours into ethanol withdrawal, the rats were intraperitoneally injected with normal saline and MPEP (2.5, 5.0, 10, 20, 30 mg/kg) and were assessed for ethanol withdrawal induced anxiety-like syndrome using an automated elevated plus maze and an open field. MPEP at 10 mg/kg significantly attenuated ethanol withdrawal induced anxiety without any compromising effects on locomotor activities. Despite reversing several indices of ethanol withdrawal induced anxiety in both the elevated plus maze and the open field, low doses of MPEP (2.5, 5 mg/kg) significantly compromised the locomotor activities of ethanol withdrawn rats. High doses of MPEP (20 and 30 mg/kg) significantly attenuated withdrawal anxiety when tested in the elevated plus maze but not in the open field. Administration of MPEP (2.5, 5, 10, 20, 30 mg/kg) has no significant compromising effect on the locomotor activities of ethanol naïve rats. Despite significantly reducing withdrawal anxiety in both behavioural paradigms at 10 mg/kg, the compromising effects of low and high doses of MPEP must be further explored along with the therapeutic efficiency of this drug for relieving withdrawal induced anxiety. 2013 Article PeerReviewed application/pdf en http://eprints.usm.my/35805/1/Kumar_et_al_BBF_2013.pdf Kumar, Jaya and Hapidin, Hermizi and Get Bee, Yvonne-Tee and Ismail, Zalina (2013) Effects of the mGluR5 antagonist MPEP on ethanol withdrawal induced anxiety-like syndrome in rats. Behavioral and Brain Functions, 9 (43). pp. 1-13.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RA0421 Public health. Hygiene. Preventive Medicine
spellingShingle RA0421 Public health. Hygiene. Preventive Medicine
Kumar, Jaya
Hapidin, Hermizi
Get Bee, Yvonne-Tee
Ismail, Zalina
Effects of the mGluR5 antagonist MPEP on ethanol withdrawal induced anxiety-like syndrome in rats
description Abstinence from chronic ethanol consumption leads to the manifestation of a variety of symptoms attributed to central nervous system hyperexcitability, such as increased irritability, anxiety, and restlessness. Recent studies have demonstrated the importance of metabotropic glutamate receptor 5 (mGluR5) in addictive behaviours. This study investigates the effects of the mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) on ethanol withdrawal induced anxiety using two behavioural paradigms. Male Wistar rats were fed a Modified Liquid Diet (MLD) containing low fat cow milk, sucrose, and maltodextrin with a gradual introduction of 2.4%, 4.8% and 7.2% ethanol for 20 days. Six hours into ethanol withdrawal, the rats were intraperitoneally injected with normal saline and MPEP (2.5, 5.0, 10, 20, 30 mg/kg) and were assessed for ethanol withdrawal induced anxiety-like syndrome using an automated elevated plus maze and an open field. MPEP at 10 mg/kg significantly attenuated ethanol withdrawal induced anxiety without any compromising effects on locomotor activities. Despite reversing several indices of ethanol withdrawal induced anxiety in both the elevated plus maze and the open field, low doses of MPEP (2.5, 5 mg/kg) significantly compromised the locomotor activities of ethanol withdrawn rats. High doses of MPEP (20 and 30 mg/kg) significantly attenuated withdrawal anxiety when tested in the elevated plus maze but not in the open field. Administration of MPEP (2.5, 5, 10, 20, 30 mg/kg) has no significant compromising effect on the locomotor activities of ethanol naïve rats. Despite significantly reducing withdrawal anxiety in both behavioural paradigms at 10 mg/kg, the compromising effects of low and high doses of MPEP must be further explored along with the therapeutic efficiency of this drug for relieving withdrawal induced anxiety.
format Article
author Kumar, Jaya
Hapidin, Hermizi
Get Bee, Yvonne-Tee
Ismail, Zalina
author_facet Kumar, Jaya
Hapidin, Hermizi
Get Bee, Yvonne-Tee
Ismail, Zalina
author_sort Kumar, Jaya
title Effects of the mGluR5 antagonist MPEP on ethanol withdrawal induced anxiety-like syndrome in rats
title_short Effects of the mGluR5 antagonist MPEP on ethanol withdrawal induced anxiety-like syndrome in rats
title_full Effects of the mGluR5 antagonist MPEP on ethanol withdrawal induced anxiety-like syndrome in rats
title_fullStr Effects of the mGluR5 antagonist MPEP on ethanol withdrawal induced anxiety-like syndrome in rats
title_full_unstemmed Effects of the mGluR5 antagonist MPEP on ethanol withdrawal induced anxiety-like syndrome in rats
title_sort effects of the mglur5 antagonist mpep on ethanol withdrawal induced anxiety-like syndrome in rats
publishDate 2013
url http://eprints.usm.my/35805/1/Kumar_et_al_BBF_2013.pdf
http://eprints.usm.my/35805/
_version_ 1643708601982779392
score 13.211869

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