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High yield synthesis of kojic ester using dual enzymes system and their antibacterial activity

Enzymatic synthesis of kojic ester, a bio-based whitening agent, was successfully carried out via esterification reaction between oleic acid and kojic acid. Commercial immobilized lipases of Novozym 435 and Lipozyme RM IM were used in combination as biocatalyst in the reaction system. Various reacti...

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Main Authors: S.M., Radzi,, N.J.A., Rahman,, H.M., Noor,, M., Basri,
Format: Conference Paper
Language:en_US
Published: 2015
Subjects:
Antimicrobial activity
Dual enzymes system
Kojic ester
Optimization
Whitening agent
Online Access:http://ddms.usim.edu.my/handle/123456789/9201
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spelling my.usim-92012015-08-25T04:48:58Z High yield synthesis of kojic ester using dual enzymes system and their antibacterial activity S.M., Radzi, N.J.A., Rahman, H.M., Noor, M., Basri, Antimicrobial activity Dual enzymes system Kojic ester Optimization Whitening agent Enzymatic synthesis of kojic ester, a bio-based whitening agent, was successfully carried out via esterification reaction between oleic acid and kojic acid. Commercial immobilized lipases of Novozym 435 and Lipozyme RM IM were used in combination as biocatalyst in the reaction system. Various reaction parameters were chosen to optimize the reaction in order to obtain a high yield of kojic ester including the best ratio of lipases, reaction time and reaction temperature. The optimum conditions for the synthesis of kojic ester was achieved at reaction time of 12 hours, temperature of 60 °C and equal ratio of lipases to produce more than 70 % yield. Antimicrobial tests of synthesized kojic ester towards several types of bacteria via Minimum inhibitory concentration (MIC) and Minimum bactericidal concentration (MBC) analyses were also examined. The results obtained suggested that kojic ester exhibits a good bactericidal effect towards all bacteria tested such as Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Salmonella typhimurium. Copyright © 2014 Trans Tech Publications Ltd, Switzerland. 2015-08-25T04:48:58Z 2015-08-25T04:48:58Z 2014-01-01 Conference Paper 9783-0378-5937-7 1013-9826 http://ddms.usim.edu.my/handle/123456789/9201 en_US
institution Universiti Sains Islam Malaysia
building USIM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universit Sains Islam i Malaysia
content_source USIM Institutional Repository
url_provider http://ddms.usim.edu.my/
language en_US
topic Antimicrobial activity
Dual enzymes system
Kojic ester
Optimization
Whitening agent
spellingShingle Antimicrobial activity
Dual enzymes system
Kojic ester
Optimization
Whitening agent
S.M., Radzi,
N.J.A., Rahman,
H.M., Noor,
M., Basri,
High yield synthesis of kojic ester using dual enzymes system and their antibacterial activity
description Enzymatic synthesis of kojic ester, a bio-based whitening agent, was successfully carried out via esterification reaction between oleic acid and kojic acid. Commercial immobilized lipases of Novozym 435 and Lipozyme RM IM were used in combination as biocatalyst in the reaction system. Various reaction parameters were chosen to optimize the reaction in order to obtain a high yield of kojic ester including the best ratio of lipases, reaction time and reaction temperature. The optimum conditions for the synthesis of kojic ester was achieved at reaction time of 12 hours, temperature of 60 °C and equal ratio of lipases to produce more than 70 % yield. Antimicrobial tests of synthesized kojic ester towards several types of bacteria via Minimum inhibitory concentration (MIC) and Minimum bactericidal concentration (MBC) analyses were also examined. The results obtained suggested that kojic ester exhibits a good bactericidal effect towards all bacteria tested such as Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Salmonella typhimurium. Copyright © 2014 Trans Tech Publications Ltd, Switzerland.
format Conference Paper
author S.M., Radzi,
N.J.A., Rahman,
H.M., Noor,
M., Basri,
author_facet S.M., Radzi,
N.J.A., Rahman,
H.M., Noor,
M., Basri,
author_sort S.M., Radzi,
title High yield synthesis of kojic ester using dual enzymes system and their antibacterial activity
title_short High yield synthesis of kojic ester using dual enzymes system and their antibacterial activity
title_full High yield synthesis of kojic ester using dual enzymes system and their antibacterial activity
title_fullStr High yield synthesis of kojic ester using dual enzymes system and their antibacterial activity
title_full_unstemmed High yield synthesis of kojic ester using dual enzymes system and their antibacterial activity
title_sort high yield synthesis of kojic ester using dual enzymes system and their antibacterial activity
publishDate 2015
url http://ddms.usim.edu.my/handle/123456789/9201
_version_ 1645152561412440064
score 13.222552

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