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Effects of Eurycoma longifolia extract on the isolated rat heart

Introduction: Eurycoma longifolia (E. longifolia) which is better known locally as Tongkat Ali is an indigenous plant in Malaysia. It belongs to the family of Simaroubaceae and is popular as a traditional medicine for its aphrodisiac properties. Throughout the years, several studies have been conduc...

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Main Authors: R.H, Mokhtar,, N., Abdullah,, A., Ayob,
Format: Article
Language:en_US
Published: International Islamic University Malaysia 2015
Subjects:
Cardiovascular
Eurycoma longifolia
Langendorff technique
Tongkat ali
Online Access:http://ddms.usim.edu.my/handle/123456789/8791
http://iiumedic.net/imjm/v1/download/Volume%2013%20No%201/IMJM%20Vol%2013%20No%201%20p25-34.pdf
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spelling my.usim-87912015-12-31T08:03:57Z Effects of Eurycoma longifolia extract on the isolated rat heart R.H, Mokhtar, N., Abdullah, A., Ayob, Cardiovascular Eurycoma longifolia Langendorff technique Tongkat ali Introduction: Eurycoma longifolia (E. longifolia) which is better known locally as Tongkat Ali is an indigenous plant in Malaysia. It belongs to the family of Simaroubaceae and is popular as a traditional medicine for its aphrodisiac properties. Throughout the years, several studies have been conducted to prove its effect on aphrodisiac action, antimalarial, antibacterial and anxiolytic properties but its effect to the cardiovascular system had not been fully explored. This study was aimed to demonstrate the changes that take place in the isolated heart following the injection of the extract. Methods: Three parameters that were measured included the coronary perfusion pressure (CPP), the left ventricular developed pressure (LVDP) and the heart rate (HR). Eighteen isolated rat hearts were used and were divided equally into three groups. The first group was to observe the effect of Isoprenaline, a 6 agonist while the second group was to see the effect of sodium nitroprusside (SNP), a nitric oxide (NO) donor. The dose which gave the maximum effect for these two positive controls was used to compare with the effect of E. longifolia water extract in the third group of rats. Isolated heart was mounted using the Langendorff apparatus and perfused with modified Krebs-Henseleit buffer. Doses of controls and the extract were instilled through an injection port, and the effect of each dose was monitored. Results: E. longifolia extract was found to reduce the CPP in normotensive rat at two of the highest doses. A dose of 1.0 mg of the extract reduced the CPP significantly from 34.52 ± 4.99 mmHg of the baseline value to 31.99 ± 4.93 mmHg while the dose of 10.0 mg of the extract reduced the CPP significantly to 32.67 ± 3.89 mmHg. However, there were no significant changes of effect of the extract on the LVDP and HR as compared to control. Conclusion: These early findings suggest that E. longifolia extract may have vasodilatory property, which supports its traditional usage with minimum cardiovascular side effects. 2015-07-13T08:04:33Z 2015-07-13T08:04:33Z 2014 Article 18234631 http://ddms.usim.edu.my/handle/123456789/8791 http://iiumedic.net/imjm/v1/download/Volume%2013%20No%201/IMJM%20Vol%2013%20No%201%20p25-34.pdf en_US International Islamic University Malaysia
institution Universiti Sains Islam Malaysia
building USIM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universit Sains Islam i Malaysia
content_source USIM Institutional Repository
url_provider http://ddms.usim.edu.my/
language en_US
topic Cardiovascular
Eurycoma longifolia
Langendorff technique
Tongkat ali
spellingShingle Cardiovascular
Eurycoma longifolia
Langendorff technique
Tongkat ali
R.H, Mokhtar,
N., Abdullah,
A., Ayob,
Effects of Eurycoma longifolia extract on the isolated rat heart
description Introduction: Eurycoma longifolia (E. longifolia) which is better known locally as Tongkat Ali is an indigenous plant in Malaysia. It belongs to the family of Simaroubaceae and is popular as a traditional medicine for its aphrodisiac properties. Throughout the years, several studies have been conducted to prove its effect on aphrodisiac action, antimalarial, antibacterial and anxiolytic properties but its effect to the cardiovascular system had not been fully explored. This study was aimed to demonstrate the changes that take place in the isolated heart following the injection of the extract. Methods: Three parameters that were measured included the coronary perfusion pressure (CPP), the left ventricular developed pressure (LVDP) and the heart rate (HR). Eighteen isolated rat hearts were used and were divided equally into three groups. The first group was to observe the effect of Isoprenaline, a 6 agonist while the second group was to see the effect of sodium nitroprusside (SNP), a nitric oxide (NO) donor. The dose which gave the maximum effect for these two positive controls was used to compare with the effect of E. longifolia water extract in the third group of rats. Isolated heart was mounted using the Langendorff apparatus and perfused with modified Krebs-Henseleit buffer. Doses of controls and the extract were instilled through an injection port, and the effect of each dose was monitored. Results: E. longifolia extract was found to reduce the CPP in normotensive rat at two of the highest doses. A dose of 1.0 mg of the extract reduced the CPP significantly from 34.52 ± 4.99 mmHg of the baseline value to 31.99 ± 4.93 mmHg while the dose of 10.0 mg of the extract reduced the CPP significantly to 32.67 ± 3.89 mmHg. However, there were no significant changes of effect of the extract on the LVDP and HR as compared to control. Conclusion: These early findings suggest that E. longifolia extract may have vasodilatory property, which supports its traditional usage with minimum cardiovascular side effects.
format Article
author R.H, Mokhtar,
N., Abdullah,
A., Ayob,
author_facet R.H, Mokhtar,
N., Abdullah,
A., Ayob,
author_sort R.H, Mokhtar,
title Effects of Eurycoma longifolia extract on the isolated rat heart
title_short Effects of Eurycoma longifolia extract on the isolated rat heart
title_full Effects of Eurycoma longifolia extract on the isolated rat heart
title_fullStr Effects of Eurycoma longifolia extract on the isolated rat heart
title_full_unstemmed Effects of Eurycoma longifolia extract on the isolated rat heart
title_sort effects of eurycoma longifolia extract on the isolated rat heart
publisher International Islamic University Malaysia
publishDate 2015
url http://ddms.usim.edu.my/handle/123456789/8791
http://iiumedic.net/imjm/v1/download/Volume%2013%20No%201/IMJM%20Vol%2013%20No%201%20p25-34.pdf
_version_ 1645152474750779392
score 13.222552

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