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Antimicrobial activity of the ethanolic extract of Coleus aromaticus against common wound pathogens

Antibacterial activity of the ethanolic extract of Coleus aromaticus leaves and roots were tested against Gram positive and Gram negative wound pathogenic microorganisms using disc diffusion method, time kill assay and the determination of Minimum Inhibitory Concentration (MIC) and Minimum Bacterici...

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Main Authors: K., Muniandy,, Z., Hassan,, M.H., Mohd Isa,
Format: Article
Language:en_US
Published: Research Journal of Pharmaceutical, Biological and Chemical Sciences 2015
Subjects:
Coleus aromaticus
Minimum bactericidal concentration
Minimum inhibitory concentration
Time kill assay
Wound pathogens
Online Access:http://ddms.usim.edu.my/handle/123456789/8524
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spelling my.usim-85242017-02-23T04:24:37Z Antimicrobial activity of the ethanolic extract of Coleus aromaticus against common wound pathogens K., Muniandy, Z., Hassan, M.H., Mohd Isa, Coleus aromaticus Minimum bactericidal concentration Minimum inhibitory concentration Time kill assay Wound pathogens Antibacterial activity of the ethanolic extract of Coleus aromaticus leaves and roots were tested against Gram positive and Gram negative wound pathogenic microorganisms using disc diffusion method, time kill assay and the determination of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). Disc diffusion test of the ethanolic extract of C. aromaticus demonstrated good antibacterial activity against Escherichia coli, Proteus mirabilis and Staphylococcus aureus and moderate activity against Pseudomonas aeruginosa and Klebsiella pneumonia. The MIC values ranged from 1.04 to 2.60 mg/ml for Gram negative bacteria where as the MIC value for Gram positive bacteria (S. aureus) was 1.30 mg/ml. Average log reduction was noted to be more than 3, after 24 hours in 1 x MIC where as the average log reduction in 2 x MIC was more than 3 after 3 hours of incubation. This antibacterial study indicates the crude extract as a bioactive compound that could be useful to develop new antimicrobial agents and it can be used to assist us in reducing the burden of cost and drug resistance. 2015-06-26T01:35:21Z 2015-06-26T01:35:21Z 2014 Article 9758585 http://ddms.usim.edu.my/handle/123456789/8524 en_US Research Journal of Pharmaceutical, Biological and Chemical Sciences
institution Universiti Sains Islam Malaysia
building USIM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universit Sains Islam i Malaysia
content_source USIM Institutional Repository
url_provider http://ddms.usim.edu.my/
language en_US
topic Coleus aromaticus
Minimum bactericidal concentration
Minimum inhibitory concentration
Time kill assay
Wound pathogens
spellingShingle Coleus aromaticus
Minimum bactericidal concentration
Minimum inhibitory concentration
Time kill assay
Wound pathogens
K., Muniandy,
Z., Hassan,
M.H., Mohd Isa,
Antimicrobial activity of the ethanolic extract of Coleus aromaticus against common wound pathogens
description Antibacterial activity of the ethanolic extract of Coleus aromaticus leaves and roots were tested against Gram positive and Gram negative wound pathogenic microorganisms using disc diffusion method, time kill assay and the determination of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). Disc diffusion test of the ethanolic extract of C. aromaticus demonstrated good antibacterial activity against Escherichia coli, Proteus mirabilis and Staphylococcus aureus and moderate activity against Pseudomonas aeruginosa and Klebsiella pneumonia. The MIC values ranged from 1.04 to 2.60 mg/ml for Gram negative bacteria where as the MIC value for Gram positive bacteria (S. aureus) was 1.30 mg/ml. Average log reduction was noted to be more than 3, after 24 hours in 1 x MIC where as the average log reduction in 2 x MIC was more than 3 after 3 hours of incubation. This antibacterial study indicates the crude extract as a bioactive compound that could be useful to develop new antimicrobial agents and it can be used to assist us in reducing the burden of cost and drug resistance.
format Article
author K., Muniandy,
Z., Hassan,
M.H., Mohd Isa,
author_facet K., Muniandy,
Z., Hassan,
M.H., Mohd Isa,
author_sort K., Muniandy,
title Antimicrobial activity of the ethanolic extract of Coleus aromaticus against common wound pathogens
title_short Antimicrobial activity of the ethanolic extract of Coleus aromaticus against common wound pathogens
title_full Antimicrobial activity of the ethanolic extract of Coleus aromaticus against common wound pathogens
title_fullStr Antimicrobial activity of the ethanolic extract of Coleus aromaticus against common wound pathogens
title_full_unstemmed Antimicrobial activity of the ethanolic extract of Coleus aromaticus against common wound pathogens
title_sort antimicrobial activity of the ethanolic extract of coleus aromaticus against common wound pathogens
publisher Research Journal of Pharmaceutical, Biological and Chemical Sciences
publishDate 2015
url http://ddms.usim.edu.my/handle/123456789/8524
_version_ 1645152432846536704
score 13.222552

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