Cover Image

Virgin Coconut Oil Prevents Blood Pressure Elevation and Improves Endothelial Functions in Rats Fed with Repeatedly Heated Palm Oil

This study was performed to explore the effects of virgin coconut oil (VCO) in male rats that were fed with repeatedly heated palm oil on blood pressure, plasma nitric oxide level, and vascular reactivity. Thirty-two male Sprague-Dawley rats were divided into four groups: (i) control (basal diet), (...

Full description

Saved in:
Bibliographic Details
Main Authors: Yusof, Kamisah,, Kamsiah, Jaarin,, Hj Mohd Saad, Qodriyah,, Badlishah Sham, Nurul-Iman,
Format: Article
Language:en_US
Published: Hindawi Publishing Corporation 2015
Subjects:
Impaired Vasorelaxation
Metabolic Syndrome
Hypertension
Atherosclerosis
Consumption
Parameters
Increases
Women
Online Access:http://ddms.usim.edu.my/handle/123456789/8464
http://www.hindawi.com/journals/ecam/2013/629329/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.usim-8464
record_format dspace
spelling my.usim-84642015-12-29T08:39:39Z Virgin Coconut Oil Prevents Blood Pressure Elevation and Improves Endothelial Functions in Rats Fed with Repeatedly Heated Palm Oil Yusof, Kamisah, Kamsiah, Jaarin, Hj Mohd Saad, Qodriyah, Badlishah Sham, Nurul-Iman, Impaired Vasorelaxation Metabolic Syndrome Hypertension Atherosclerosis Consumption Parameters Increases Women This study was performed to explore the effects of virgin coconut oil (VCO) in male rats that were fed with repeatedly heated palm oil on blood pressure, plasma nitric oxide level, and vascular reactivity. Thirty-two male Sprague-Dawley rats were divided into four groups: (i) control (basal diet), (ii) VCO (1.42 mL/kg, oral), (iii) five-times-heated palm oil (15%) (5HPO), and (iv) five-times-heated palm oil (15%) and VCO(1.42 mL/kg, oral) (5HPO + VCO). Blood pressure was significantly increased in the group that was given the 5HPO diet compared to the control group. Blood pressure in the 5HPO + VCO group was significantly lower than the 5HPO group. Plasma nitric oxide (NO) level in the 5HPO group was significantly lower compared to the control group, whereas in the 5HPO + VCO group, the plasma NO level was significantly higher compared to the 5HPO group. Aortic rings from the 5HPO group exhibited attenuated relaxation in response to acetylcholine and sodium nitroprusside as well as increased vasoconstriction to phenylephrine compared to the control group. Aortic rings from the 5HPO + VCO group showed only attenuated vasoconstriction to phenylephrine compared to the 5HPO group. In conclusion, VCO prevents blood pressure elevation and improves endothelial functions in rats fed with repeatedly heated palm oil. 2015-06-19T06:56:01Z 2015-06-19T06:56:01Z 2013 Article 1741-427X http://ddms.usim.edu.my/handle/123456789/8464 http://www.hindawi.com/journals/ecam/2013/629329/ en_US Hindawi Publishing Corporation
institution Universiti Sains Islam Malaysia
building USIM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universit Sains Islam i Malaysia
content_source USIM Institutional Repository
url_provider http://ddms.usim.edu.my/
language en_US
topic Impaired Vasorelaxation
Metabolic Syndrome
Hypertension
Atherosclerosis
Consumption
Parameters
Increases
Women
spellingShingle Impaired Vasorelaxation
Metabolic Syndrome
Hypertension
Atherosclerosis
Consumption
Parameters
Increases
Women
Yusof, Kamisah,
Kamsiah, Jaarin,
Hj Mohd Saad, Qodriyah,
Badlishah Sham, Nurul-Iman,
Virgin Coconut Oil Prevents Blood Pressure Elevation and Improves Endothelial Functions in Rats Fed with Repeatedly Heated Palm Oil
description This study was performed to explore the effects of virgin coconut oil (VCO) in male rats that were fed with repeatedly heated palm oil on blood pressure, plasma nitric oxide level, and vascular reactivity. Thirty-two male Sprague-Dawley rats were divided into four groups: (i) control (basal diet), (ii) VCO (1.42 mL/kg, oral), (iii) five-times-heated palm oil (15%) (5HPO), and (iv) five-times-heated palm oil (15%) and VCO(1.42 mL/kg, oral) (5HPO + VCO). Blood pressure was significantly increased in the group that was given the 5HPO diet compared to the control group. Blood pressure in the 5HPO + VCO group was significantly lower than the 5HPO group. Plasma nitric oxide (NO) level in the 5HPO group was significantly lower compared to the control group, whereas in the 5HPO + VCO group, the plasma NO level was significantly higher compared to the 5HPO group. Aortic rings from the 5HPO group exhibited attenuated relaxation in response to acetylcholine and sodium nitroprusside as well as increased vasoconstriction to phenylephrine compared to the control group. Aortic rings from the 5HPO + VCO group showed only attenuated vasoconstriction to phenylephrine compared to the 5HPO group. In conclusion, VCO prevents blood pressure elevation and improves endothelial functions in rats fed with repeatedly heated palm oil.
format Article
author Yusof, Kamisah,
Kamsiah, Jaarin,
Hj Mohd Saad, Qodriyah,
Badlishah Sham, Nurul-Iman,
author_facet Yusof, Kamisah,
Kamsiah, Jaarin,
Hj Mohd Saad, Qodriyah,
Badlishah Sham, Nurul-Iman,
author_sort Yusof, Kamisah,
title Virgin Coconut Oil Prevents Blood Pressure Elevation and Improves Endothelial Functions in Rats Fed with Repeatedly Heated Palm Oil
title_short Virgin Coconut Oil Prevents Blood Pressure Elevation and Improves Endothelial Functions in Rats Fed with Repeatedly Heated Palm Oil
title_full Virgin Coconut Oil Prevents Blood Pressure Elevation and Improves Endothelial Functions in Rats Fed with Repeatedly Heated Palm Oil
title_fullStr Virgin Coconut Oil Prevents Blood Pressure Elevation and Improves Endothelial Functions in Rats Fed with Repeatedly Heated Palm Oil
title_full_unstemmed Virgin Coconut Oil Prevents Blood Pressure Elevation and Improves Endothelial Functions in Rats Fed with Repeatedly Heated Palm Oil
title_sort virgin coconut oil prevents blood pressure elevation and improves endothelial functions in rats fed with repeatedly heated palm oil
publisher Hindawi Publishing Corporation
publishDate 2015
url http://ddms.usim.edu.my/handle/123456789/8464
http://www.hindawi.com/journals/ecam/2013/629329/
_version_ 1645152421989580800
score 13.211869

Similar Items