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The anthelmintic efficacy of papaya latex in a rodent-nematode model is not dependent on fasting before treatment

In earlier studies of the anthelmintic activity of plant cysteine proteinases (CPs), a period of food deprivation was routinely employed before administration of CPs, but there has been no systematic evaluation as to whether this does actually benefit the anthelmintic efficacy. Therefore, we assesse...

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Main Authors: W., Luoga,, F., Mansur,, I. R., Duce,, J. M., Behnke,, M. C., Garnett,, DJ., Buttle,
Format: Article
Language:en_US
Published: Cambridge University Press 2015
Subjects:
Plant Cysteine Proteinases
Heligmosomoides-Polygyrus
In-Vivo
Gastrointestinal Nematode
Drug Bioavailability
Food
Mice
Echinococcosis
Tetracycline
Vitro
Online Access:http://ddms.usim.edu.my/handle/123456789/8441
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spelling my.usim-84412017-02-23T02:14:47Z The anthelmintic efficacy of papaya latex in a rodent-nematode model is not dependent on fasting before treatment W., Luoga, F., Mansur, I. R., Duce, J. M., Behnke, M. C., Garnett, DJ., Buttle, Plant Cysteine Proteinases Heligmosomoides-Polygyrus In-Vivo Gastrointestinal Nematode Drug Bioavailability Food Mice Echinococcosis Tetracycline Vitro In earlier studies of the anthelmintic activity of plant cysteine proteinases (CPs), a period of food deprivation was routinely employed before administration of CPs, but there has been no systematic evaluation as to whether this does actually benefit the anthelmintic efficacy. Therefore, we assessed the effect of fasting on the efficacy of CPs from papaya latex (PL) against Heligmosomoides bakeri in C3H mice. We used a refined, supernatant extract of papaya latex (PLS) with known active enzyme content. The animals were divided into three groups (fasted prior to treatment with PLS, not fasted but treated with PLS and fasted but given only water). The study demonstrated clearly that although food deprivation had been routinely employed in much of the earlier work on CPs in mice infected with nematodes, fasting has no beneficial effect on the efficacy of PLS against H. bakeri infections. Administration of CPs to fed animals will also reduce the stress associated with fasting. 2015-06-19T03:38:27Z 2015-06-19T03:38:27Z 2012 Article 0022-149X http://ddms.usim.edu.my/handle/123456789/8441 en_US Cambridge University Press
institution Universiti Sains Islam Malaysia
building USIM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universit Sains Islam i Malaysia
content_source USIM Institutional Repository
url_provider http://ddms.usim.edu.my/
language en_US
topic Plant Cysteine Proteinases
Heligmosomoides-Polygyrus
In-Vivo
Gastrointestinal Nematode
Drug Bioavailability
Food
Mice
Echinococcosis
Tetracycline
Vitro
spellingShingle Plant Cysteine Proteinases
Heligmosomoides-Polygyrus
In-Vivo
Gastrointestinal Nematode
Drug Bioavailability
Food
Mice
Echinococcosis
Tetracycline
Vitro
W., Luoga,
F., Mansur,
I. R., Duce,
J. M., Behnke,
M. C., Garnett,
DJ., Buttle,
The anthelmintic efficacy of papaya latex in a rodent-nematode model is not dependent on fasting before treatment
description In earlier studies of the anthelmintic activity of plant cysteine proteinases (CPs), a period of food deprivation was routinely employed before administration of CPs, but there has been no systematic evaluation as to whether this does actually benefit the anthelmintic efficacy. Therefore, we assessed the effect of fasting on the efficacy of CPs from papaya latex (PL) against Heligmosomoides bakeri in C3H mice. We used a refined, supernatant extract of papaya latex (PLS) with known active enzyme content. The animals were divided into three groups (fasted prior to treatment with PLS, not fasted but treated with PLS and fasted but given only water). The study demonstrated clearly that although food deprivation had been routinely employed in much of the earlier work on CPs in mice infected with nematodes, fasting has no beneficial effect on the efficacy of PLS against H. bakeri infections. Administration of CPs to fed animals will also reduce the stress associated with fasting.
format Article
author W., Luoga,
F., Mansur,
I. R., Duce,
J. M., Behnke,
M. C., Garnett,
DJ., Buttle,
author_facet W., Luoga,
F., Mansur,
I. R., Duce,
J. M., Behnke,
M. C., Garnett,
DJ., Buttle,
author_sort W., Luoga,
title The anthelmintic efficacy of papaya latex in a rodent-nematode model is not dependent on fasting before treatment
title_short The anthelmintic efficacy of papaya latex in a rodent-nematode model is not dependent on fasting before treatment
title_full The anthelmintic efficacy of papaya latex in a rodent-nematode model is not dependent on fasting before treatment
title_fullStr The anthelmintic efficacy of papaya latex in a rodent-nematode model is not dependent on fasting before treatment
title_full_unstemmed The anthelmintic efficacy of papaya latex in a rodent-nematode model is not dependent on fasting before treatment
title_sort anthelmintic efficacy of papaya latex in a rodent-nematode model is not dependent on fasting before treatment
publisher Cambridge University Press
publishDate 2015
url http://ddms.usim.edu.my/handle/123456789/8441
_version_ 1645152418126626816
score 13.222552

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