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Risk Factors Associated with Unconjugated Neonatal Hyperbilirubinemia in Malaysian Neonates

Methods: A prospective study was conducted to investigate the effects of glucose-6-phosphate dehydrogenase (G6PD) mutation, variant uridine diphosphate glucuronosyltransferase UGT1A1 gene and hepatic organic anion transporter protein (OATP2) gene on a group of neonates. Hyperbilirubinemia was define...

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Main Authors: Feiliang, Wong,, NemYun, Boo,, Ainoon, Othman,
Format: Article
Language:English
Published: Oxford Univ Press 2015
Subjects:
Keratinocyte-Like Cells
Embryonic Stem-Cells
Epithelial-Cells
Epidermal Morphogenesis
Gene-Expression
In-Vitro
Differentiation
Membrane
Online Access:http://ddms.usim.edu.my/handle/123456789/8397
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spelling my.usim-83972017-02-23T02:54:19Z Risk Factors Associated with Unconjugated Neonatal Hyperbilirubinemia in Malaysian Neonates Feiliang, Wong, NemYun, Boo, Ainoon, Othman, Keratinocyte-Like Cells Embryonic Stem-Cells Epithelial-Cells Epidermal Morphogenesis Gene-Expression In-Vitro Differentiation Membrane Methods: A prospective study was conducted to investigate the effects of glucose-6-phosphate dehydrogenase (G6PD) mutation, variant uridine diphosphate glucuronosyltransferase UGT1A1 gene and hepatic organic anion transporter protein (OATP2) gene on a group of neonates. Hyperbilirubinemia was defined as a total serum bilirubin level of epsilon 250 mu mol/l. Results: Of 318 neonates, 52 (16.4%) had hyperbilirubinemia. The incidence of G6PD mutation was 5.4% (15/280) among these infants. The incidence of G6PD mutation was significantly higher in the male neonates with hyperbilirubinemia (7.8%) when compared with the normal male neonates without hyperbilirubinemia (1.8%; p = 0.03). Logistic regression analysis showed that the significant risk factors for neonatal hyperbilirubinemia were Malay ethnicity [adjusted odds ratio (OR), 2.77; 95% confidence interval (CI): 1.31-5.86; p = 0.007] and G6PD mutation (adjusted OR, 3.29; 95% CI: 1.06-10.1820; p = 0.039). The gender, birth weight and gestation age of neonates, variant c.211G > A and variant of OATP2 gene were not significant. Conclusions: Neonates with Malay ethnicity and G6PD mutation were at risk for hyperbilirubinemia. 2015-06-16T06:38:09Z 2015-06-16T06:38:09Z 2013 Article 0142-6338 http://ddms.usim.edu.my/handle/123456789/8397 en Oxford Univ Press
institution Universiti Sains Islam Malaysia
building USIM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universit Sains Islam i Malaysia
content_source USIM Institutional Repository
url_provider http://ddms.usim.edu.my/
language English
topic Keratinocyte-Like Cells
Embryonic Stem-Cells
Epithelial-Cells
Epidermal Morphogenesis
Gene-Expression
In-Vitro
Differentiation
Membrane
spellingShingle Keratinocyte-Like Cells
Embryonic Stem-Cells
Epithelial-Cells
Epidermal Morphogenesis
Gene-Expression
In-Vitro
Differentiation
Membrane
Feiliang, Wong,
NemYun, Boo,
Ainoon, Othman,
Risk Factors Associated with Unconjugated Neonatal Hyperbilirubinemia in Malaysian Neonates
description Methods: A prospective study was conducted to investigate the effects of glucose-6-phosphate dehydrogenase (G6PD) mutation, variant uridine diphosphate glucuronosyltransferase UGT1A1 gene and hepatic organic anion transporter protein (OATP2) gene on a group of neonates. Hyperbilirubinemia was defined as a total serum bilirubin level of epsilon 250 mu mol/l. Results: Of 318 neonates, 52 (16.4%) had hyperbilirubinemia. The incidence of G6PD mutation was 5.4% (15/280) among these infants. The incidence of G6PD mutation was significantly higher in the male neonates with hyperbilirubinemia (7.8%) when compared with the normal male neonates without hyperbilirubinemia (1.8%; p = 0.03). Logistic regression analysis showed that the significant risk factors for neonatal hyperbilirubinemia were Malay ethnicity [adjusted odds ratio (OR), 2.77; 95% confidence interval (CI): 1.31-5.86; p = 0.007] and G6PD mutation (adjusted OR, 3.29; 95% CI: 1.06-10.1820; p = 0.039). The gender, birth weight and gestation age of neonates, variant c.211G > A and variant of OATP2 gene were not significant. Conclusions: Neonates with Malay ethnicity and G6PD mutation were at risk for hyperbilirubinemia.
format Article
author Feiliang, Wong,
NemYun, Boo,
Ainoon, Othman,
author_facet Feiliang, Wong,
NemYun, Boo,
Ainoon, Othman,
author_sort Feiliang, Wong,
title Risk Factors Associated with Unconjugated Neonatal Hyperbilirubinemia in Malaysian Neonates
title_short Risk Factors Associated with Unconjugated Neonatal Hyperbilirubinemia in Malaysian Neonates
title_full Risk Factors Associated with Unconjugated Neonatal Hyperbilirubinemia in Malaysian Neonates
title_fullStr Risk Factors Associated with Unconjugated Neonatal Hyperbilirubinemia in Malaysian Neonates
title_full_unstemmed Risk Factors Associated with Unconjugated Neonatal Hyperbilirubinemia in Malaysian Neonates
title_sort risk factors associated with unconjugated neonatal hyperbilirubinemia in malaysian neonates
publisher Oxford Univ Press
publishDate 2015
url http://ddms.usim.edu.my/handle/123456789/8397
_version_ 1645152409347948544
score 13.222552

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