Cover Image

Production of highly enantioselective (-)-menthyl butyrate using Candida rugosa lipase immobilized on epoxy-activated supports

Optically active (-)-menthyl butyrate was synthesized by enantioselective esterification of racemic (+/-)-menthol and butyric anhydride using lipase from Candida rugosa immobilized onto epoxy-activated supports of Eupergit C and Eupergit C 250 L through physical adsorption method. The effects of var...

Full description

Saved in:
Bibliographic Details
Main Authors: SS, Othman,, M, Basri,, MZ, Hussein,, MBA, Rahman,, RNZ, Abd Rahman,, AB, Salleh,, H, Jasmani,
Format: Article
Language:English
Published: Elsevier Sci Ltd 2015
Subjects:
Immobilization
Lipase
Enantioselectivity
Epoxide
Menthyl Butyrate
Online Access:http://ddms.usim.edu.my/handle/123456789/8384
http://ac.els-cdn.com/S0308814607003779/1-s2.0-S0308814607003779-main.pdf?_tid=f7bc5d10-aea7-11e5-b0a9-00000aab0f01&acdnat=1451447394_9e1983fcf4515b90ef384e1bc1edbab0
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.usim-8384
record_format dspace
spelling my.usim-83842015-12-30T03:48:13Z Production of highly enantioselective (-)-menthyl butyrate using Candida rugosa lipase immobilized on epoxy-activated supports SS, Othman, M, Basri, MZ, Hussein, MBA, Rahman, RNZ, Abd Rahman, AB, Salleh, H, Jasmani, Immobilization Lipase Enantioselectivity Epoxide Menthyl Butyrate Optically active (-)-menthyl butyrate was synthesized by enantioselective esterification of racemic (+/-)-menthol and butyric anhydride using lipase from Candida rugosa immobilized onto epoxy-activated supports of Eupergit C and Eupergit C 250 L through physical adsorption method. The effects of various temperature, storage condition, stability in organic solvent and lipase recyclability were investigated for their influence on the enzymatic enantio selective formation of (-)-menthyl butyrate. The immobilized lipases retained high catalytic activity of up to 31% yield and 100% enantiomeric excess of the desired product, and showed better stability compared to the native lipase. They also exhibited about 50% retained activity even after incubation at higher temperatures, storage at room temperature and after long incubation in hexane. Immobilized lipases also showed considerably efficient reusability. (C) 2007 Published by Elsevier Ltd. 2015-06-16T03:33:36Z 2015-06-16T03:33:36Z 2008 Article 0308-8146 http://ddms.usim.edu.my/handle/123456789/8384 http://ac.els-cdn.com/S0308814607003779/1-s2.0-S0308814607003779-main.pdf?_tid=f7bc5d10-aea7-11e5-b0a9-00000aab0f01&acdnat=1451447394_9e1983fcf4515b90ef384e1bc1edbab0 en Elsevier Sci Ltd
institution Universiti Sains Islam Malaysia
building USIM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universit Sains Islam i Malaysia
content_source USIM Institutional Repository
url_provider http://ddms.usim.edu.my/
language English
topic Immobilization
Lipase
Enantioselectivity
Epoxide
Menthyl Butyrate
spellingShingle Immobilization
Lipase
Enantioselectivity
Epoxide
Menthyl Butyrate
SS, Othman,
M, Basri,
MZ, Hussein,
MBA, Rahman,
RNZ, Abd Rahman,
AB, Salleh,
H, Jasmani,
Production of highly enantioselective (-)-menthyl butyrate using Candida rugosa lipase immobilized on epoxy-activated supports
description Optically active (-)-menthyl butyrate was synthesized by enantioselective esterification of racemic (+/-)-menthol and butyric anhydride using lipase from Candida rugosa immobilized onto epoxy-activated supports of Eupergit C and Eupergit C 250 L through physical adsorption method. The effects of various temperature, storage condition, stability in organic solvent and lipase recyclability were investigated for their influence on the enzymatic enantio selective formation of (-)-menthyl butyrate. The immobilized lipases retained high catalytic activity of up to 31% yield and 100% enantiomeric excess of the desired product, and showed better stability compared to the native lipase. They also exhibited about 50% retained activity even after incubation at higher temperatures, storage at room temperature and after long incubation in hexane. Immobilized lipases also showed considerably efficient reusability. (C) 2007 Published by Elsevier Ltd.
format Article
author SS, Othman,
M, Basri,
MZ, Hussein,
MBA, Rahman,
RNZ, Abd Rahman,
AB, Salleh,
H, Jasmani,
author_facet SS, Othman,
M, Basri,
MZ, Hussein,
MBA, Rahman,
RNZ, Abd Rahman,
AB, Salleh,
H, Jasmani,
author_sort SS, Othman,
title Production of highly enantioselective (-)-menthyl butyrate using Candida rugosa lipase immobilized on epoxy-activated supports
title_short Production of highly enantioselective (-)-menthyl butyrate using Candida rugosa lipase immobilized on epoxy-activated supports
title_full Production of highly enantioselective (-)-menthyl butyrate using Candida rugosa lipase immobilized on epoxy-activated supports
title_fullStr Production of highly enantioselective (-)-menthyl butyrate using Candida rugosa lipase immobilized on epoxy-activated supports
title_full_unstemmed Production of highly enantioselective (-)-menthyl butyrate using Candida rugosa lipase immobilized on epoxy-activated supports
title_sort production of highly enantioselective (-)-menthyl butyrate using candida rugosa lipase immobilized on epoxy-activated supports
publisher Elsevier Sci Ltd
publishDate 2015
url http://ddms.usim.edu.my/handle/123456789/8384
http://ac.els-cdn.com/S0308814607003779/1-s2.0-S0308814607003779-main.pdf?_tid=f7bc5d10-aea7-11e5-b0a9-00000aab0f01&acdnat=1451447394_9e1983fcf4515b90ef384e1bc1edbab0
_version_ 1645152406953000960
score 13.211869

Similar Items