Staff View: Practical approach in hepatitis B e antigen-negative individuals to identify treatment candidates

Practical approach in hepatitis B e antigen-negative individuals to identify treatment candidates

The natural history of chronic hepatitis B is characterized by different phases of infection, and patients may evolve from one phase to another or may revert to a previous phase. The hepatitis B e antigen (HBeAg)negative form is the predominant infection worldwide, which consists of individuals with...

Full description

Saved in:

Bibliographic Details
Main Authors:	Ahmad Najib, Azmi,, Soek-Siam, Tan,, Rosmawati, Mohamed,
Format:	Article
Language:	English
Published:	Baishideng Publishing Group Inc 2015
Subjects:	Chronic hepatitis B Hepatitis B e antigen-negative Treatment candidates Hepatitis B s antigen level Nucleos(t)ides analogues Pegylated interferon
Online Access:	http://ddms.usim.edu.my/handle/123456789/8374
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my.usim-8374
record_format	dspace
spelling	my.usim-83742017-02-23T07:18:31Z Practical approach in hepatitis B e antigen-negative individuals to identify treatment candidates Ahmad Najib, Azmi, Soek-Siam, Tan, Rosmawati, Mohamed, Chronic hepatitis B Hepatitis B e antigen-negative Treatment candidates Hepatitis B s antigen level Nucleos(t)ides analogues Pegylated interferon The natural history of chronic hepatitis B is characterized by different phases of infection, and patients may evolve from one phase to another or may revert to a previous phase. The hepatitis B e antigen (HBeAg)negative form is the predominant infection worldwide, which consists of individuals with a range of viral replication and liver disease severity. Although alanine transaminase (ALT) remains the most accessible test available to clinicians for monitoring the liver disease status, further evaluations are required for some patients to assess if treatment is warranted. Guidance from practice guidelines together with thorough investigations and classifications of patients ensure recognition of who needs which level of care. This article aims to assist physicians in the assessment of HBeAg-negative individuals using liver biopsy or non-invasive tools such as hepatitis B s antigen quantification and transient elastography in addition to ALT and hepatitis B virus DNA, to identify who will remain stable, who will reactivate or at risk of disease progression hence will benefit from timely initiation of anti-viral therapy. (C) 2014 Baishideng Publishing Group Inc. All rights reserved. 2015-06-15T07:44:20Z 2015-06-15T07:44:20Z 2014-01-01 Article 1007-9327 2219-2840 http://ddms.usim.edu.my/handle/123456789/8374 en Baishideng Publishing Group Inc
institution	Universiti Sains Islam Malaysia
building	USIM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universit Sains Islam i Malaysia
content_source	USIM Institutional Repository
url_provider	http://ddms.usim.edu.my/
language	English
topic	Chronic hepatitis B Hepatitis B e antigen-negative Treatment candidates Hepatitis B s antigen level Nucleos(t)ides analogues Pegylated interferon
spellingShingle	Chronic hepatitis B Hepatitis B e antigen-negative Treatment candidates Hepatitis B s antigen level Nucleos(t)ides analogues Pegylated interferon Ahmad Najib, Azmi, Soek-Siam, Tan, Rosmawati, Mohamed, Practical approach in hepatitis B e antigen-negative individuals to identify treatment candidates
description	The natural history of chronic hepatitis B is characterized by different phases of infection, and patients may evolve from one phase to another or may revert to a previous phase. The hepatitis B e antigen (HBeAg)negative form is the predominant infection worldwide, which consists of individuals with a range of viral replication and liver disease severity. Although alanine transaminase (ALT) remains the most accessible test available to clinicians for monitoring the liver disease status, further evaluations are required for some patients to assess if treatment is warranted. Guidance from practice guidelines together with thorough investigations and classifications of patients ensure recognition of who needs which level of care. This article aims to assist physicians in the assessment of HBeAg-negative individuals using liver biopsy or non-invasive tools such as hepatitis B s antigen quantification and transient elastography in addition to ALT and hepatitis B virus DNA, to identify who will remain stable, who will reactivate or at risk of disease progression hence will benefit from timely initiation of anti-viral therapy. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
format	Article
author	Ahmad Najib, Azmi, Soek-Siam, Tan, Rosmawati, Mohamed,
author_facet	Ahmad Najib, Azmi, Soek-Siam, Tan, Rosmawati, Mohamed,
author_sort	Ahmad Najib, Azmi,
title	Practical approach in hepatitis B e antigen-negative individuals to identify treatment candidates
title_short	Practical approach in hepatitis B e antigen-negative individuals to identify treatment candidates
title_full	Practical approach in hepatitis B e antigen-negative individuals to identify treatment candidates
title_fullStr	Practical approach in hepatitis B e antigen-negative individuals to identify treatment candidates
title_full_unstemmed	Practical approach in hepatitis B e antigen-negative individuals to identify treatment candidates
title_sort	practical approach in hepatitis b e antigen-negative individuals to identify treatment candidates
publisher	Baishideng Publishing Group Inc
publishDate	2015
url	http://ddms.usim.edu.my/handle/123456789/8374
_version_	1645152404629356544
score	13.211869

Practical approach in hepatitis B e antigen-negative individuals to identify treatment candidates

Similar Items