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Pharmacodynamic properties of essential oils from Cymbopogon species

Pharmacodynamic research plays an important role in the development of new antibacterial agents. Characterization of this pharmacodynamic can be used to design the best dose and dosing strategy for clinical trials. The pharmacodynamic properties can be determined by studying the bactericidal activit...

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Main Authors: M. F. Mohd Fazrullah, Innsan,, M. Hairul, Shahril,, M. S., Samihah,, O. Siti, Asma,, S. Mat, Radzi,, A. K., Abd Jalil,, M. N., Hanina,
Format: Article
Language:English
Published: Academic Journals 2015
Subjects:
Cymbopogon species
pharmacodynamic
postantibiotic
bactericidal activity
postantibiotic effects (PAE)
Online Access:http://ddms.usim.edu.my/handle/123456789/8342
http://www.academicjournals.org/article/article1380897074_Innsan%20et%20al%206.pdf
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spelling my.usim-83422015-08-18T08:59:05Z Pharmacodynamic properties of essential oils from Cymbopogon species M. F. Mohd Fazrullah, Innsan, M. Hairul, Shahril, M. S., Samihah, O. Siti, Asma, S. Mat, Radzi, A. K., Abd Jalil, M. N., Hanina, Cymbopogon species pharmacodynamic postantibiotic bactericidal activity postantibiotic effects (PAE) Pharmacodynamic research plays an important role in the development of new antibacterial agents. Characterization of this pharmacodynamic can be used to design the best dose and dosing strategy for clinical trials. The pharmacodynamic properties can be determined by studying the bactericidal activity and the postantibiotic effects (PAE). Measurements of both bactericidal activity and the lag time could be useful in screening the efficacy of antimicrobial agents. In this study, the pharmacodynamic properties of essential oils from Cymbopogon flexuosus (lemongrass) and Cymbopogon nardus (citronella) as well as the combinations of both essential oils were evaluated against Staphylococcus aureus and Escherichia coli. At high concentrations (1.0 x minimum bactericidal concentration (MBC) and 0.5 x MBC), citronella and lemongrass essential oils alone or in combinations indicate high bactericidal activities toward S. aureus and E. coli, as shown by the decrease of optical absorbance values serially up to 24 h. However, these two essential oils or its combinations at lower concentrations (0.25 x MBC and 0.125 x MBC) showed the bacterial regrowth after 3 and 1 h of exposure time against S. aureus and E. Coli, respectively. Generally, citronella and lemongrass essential oils as well as its combinations indicate a significant lag of regrowth or PAE values which were more than 0.5 h towards both E. coli and S. aureus. This finding suggests that essential oils from Cymbopogon species showed a potential antimicrobial activity that can further be used for clinical treatment; thus, there is need for a study on the possible impact of PAE in the clinical situation. 2015-06-11T08:41:09Z 2015-06-11T08:41:09Z 2011 Article 1996-0816 http://ddms.usim.edu.my/handle/123456789/8342 http://www.academicjournals.org/article/article1380897074_Innsan%20et%20al%206.pdf en Academic Journals
institution Universiti Sains Islam Malaysia
building USIM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universit Sains Islam i Malaysia
content_source USIM Institutional Repository
url_provider http://ddms.usim.edu.my/
language English
topic Cymbopogon species
pharmacodynamic
postantibiotic
bactericidal activity
postantibiotic effects (PAE)
spellingShingle Cymbopogon species
pharmacodynamic
postantibiotic
bactericidal activity
postantibiotic effects (PAE)
M. F. Mohd Fazrullah, Innsan,
M. Hairul, Shahril,
M. S., Samihah,
O. Siti, Asma,
S. Mat, Radzi,
A. K., Abd Jalil,
M. N., Hanina,
Pharmacodynamic properties of essential oils from Cymbopogon species
description Pharmacodynamic research plays an important role in the development of new antibacterial agents. Characterization of this pharmacodynamic can be used to design the best dose and dosing strategy for clinical trials. The pharmacodynamic properties can be determined by studying the bactericidal activity and the postantibiotic effects (PAE). Measurements of both bactericidal activity and the lag time could be useful in screening the efficacy of antimicrobial agents. In this study, the pharmacodynamic properties of essential oils from Cymbopogon flexuosus (lemongrass) and Cymbopogon nardus (citronella) as well as the combinations of both essential oils were evaluated against Staphylococcus aureus and Escherichia coli. At high concentrations (1.0 x minimum bactericidal concentration (MBC) and 0.5 x MBC), citronella and lemongrass essential oils alone or in combinations indicate high bactericidal activities toward S. aureus and E. coli, as shown by the decrease of optical absorbance values serially up to 24 h. However, these two essential oils or its combinations at lower concentrations (0.25 x MBC and 0.125 x MBC) showed the bacterial regrowth after 3 and 1 h of exposure time against S. aureus and E. Coli, respectively. Generally, citronella and lemongrass essential oils as well as its combinations indicate a significant lag of regrowth or PAE values which were more than 0.5 h towards both E. coli and S. aureus. This finding suggests that essential oils from Cymbopogon species showed a potential antimicrobial activity that can further be used for clinical treatment; thus, there is need for a study on the possible impact of PAE in the clinical situation.
format Article
author M. F. Mohd Fazrullah, Innsan,
M. Hairul, Shahril,
M. S., Samihah,
O. Siti, Asma,
S. Mat, Radzi,
A. K., Abd Jalil,
M. N., Hanina,
author_facet M. F. Mohd Fazrullah, Innsan,
M. Hairul, Shahril,
M. S., Samihah,
O. Siti, Asma,
S. Mat, Radzi,
A. K., Abd Jalil,
M. N., Hanina,
author_sort M. F. Mohd Fazrullah, Innsan,
title Pharmacodynamic properties of essential oils from Cymbopogon species
title_short Pharmacodynamic properties of essential oils from Cymbopogon species
title_full Pharmacodynamic properties of essential oils from Cymbopogon species
title_fullStr Pharmacodynamic properties of essential oils from Cymbopogon species
title_full_unstemmed Pharmacodynamic properties of essential oils from Cymbopogon species
title_sort pharmacodynamic properties of essential oils from cymbopogon species
publisher Academic Journals
publishDate 2015
url http://ddms.usim.edu.my/handle/123456789/8342
http://www.academicjournals.org/article/article1380897074_Innsan%20et%20al%206.pdf
_version_ 1645152396237602816
score 13.222552

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