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Ca-Cleanse: Herbal Mouthwash for Oral Cancer Prevention

Majority mouthwash products which are popular in our Islamic community are not free from alcohol. There are two main issues with this kind of mouthwash (not free from alcohol), that is regarding the usage of alcohol for Islamic consumer and scientifically, it also having very strong correlation f...

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Main Authors: A. Seeni, N.A. Zulkepli, L.J. Fay, R.A. Wahab, E.M. Arief
Format: Conference Paper
Language:English
Published: 2012
Subjects:
Mouthwash > Free alcohol > Cancer chemoprevention
Online Access:http://ddms.usim.edu.my/handle/123456789/6115
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spelling my.usim-61152015-07-03T00:39:29Z Ca-Cleanse: Herbal Mouthwash for Oral Cancer Prevention A. Seeni N.A. Zulkepli L.J. Fay R.A. Wahab E.M. Arief Mouthwash--Free alcohol--Cancer chemoprevention Majority mouthwash products which are popular in our Islamic community are not free from alcohol. There are two main issues with this kind of mouthwash (not free from alcohol), that is regarding the usage of alcohol for Islamic consumer and scientifically, it also having very strong correlation for developing oral cancer. Consequently, to make it worse, our community still using it widely without any concerns on that both issues. Therefore, we have work together with QHERB Trading to produce a novel herb mouthwash product from our local Malaysian plant (root water extract) which is not only showing potentiality to kill oral-microbes but interestingly, also can act as chemopreventive agent that prevent the oral cancer carcinogenesis. The extract has low-level of antioxidants and inhibit the growth of the osteosarcoma cells and tongue carcinoma cells which also exert apoptosis features like spike features in time and dose-dependent manner. It induced the apoptosis level and increases the DNA arrest level especially at GOIG1 and G21M phase. From the western Mot analysis, it is dear that the extract suppressed the p42-ERK '/r and activated the Caspases 3 proteins which is the key role in apoptosis signaling pathway. CA-Cleanse also are non-toxic for the liver, kidney and skin fibroblast cells and very less or not detectable of heavy metals compounds. Therefore, our CA-Cleanse product has a good potentiality to be commercialized as a new mouthwash product that can prevent the oral cancer disease. 2012-12-31T04:42:26Z 2012-12-31T04:42:26Z 2012-12-31 Conference Paper http://ddms.usim.edu.my/handle/123456789/6115 en
institution Universiti Sains Islam Malaysia
building USIM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universit Sains Islam i Malaysia
content_source USIM Institutional Repository
url_provider http://ddms.usim.edu.my/
language English
topic Mouthwash--Free alcohol--Cancer chemoprevention
spellingShingle Mouthwash--Free alcohol--Cancer chemoprevention
A. Seeni
N.A. Zulkepli
L.J. Fay
R.A. Wahab
E.M. Arief
Ca-Cleanse: Herbal Mouthwash for Oral Cancer Prevention
description Majority mouthwash products which are popular in our Islamic community are not free from alcohol. There are two main issues with this kind of mouthwash (not free from alcohol), that is regarding the usage of alcohol for Islamic consumer and scientifically, it also having very strong correlation for developing oral cancer. Consequently, to make it worse, our community still using it widely without any concerns on that both issues. Therefore, we have work together with QHERB Trading to produce a novel herb mouthwash product from our local Malaysian plant (root water extract) which is not only showing potentiality to kill oral-microbes but interestingly, also can act as chemopreventive agent that prevent the oral cancer carcinogenesis. The extract has low-level of antioxidants and inhibit the growth of the osteosarcoma cells and tongue carcinoma cells which also exert apoptosis features like spike features in time and dose-dependent manner. It induced the apoptosis level and increases the DNA arrest level especially at GOIG1 and G21M phase. From the western Mot analysis, it is dear that the extract suppressed the p42-ERK '/r and activated the Caspases 3 proteins which is the key role in apoptosis signaling pathway. CA-Cleanse also are non-toxic for the liver, kidney and skin fibroblast cells and very less or not detectable of heavy metals compounds. Therefore, our CA-Cleanse product has a good potentiality to be commercialized as a new mouthwash product that can prevent the oral cancer disease.
format Conference Paper
author A. Seeni
N.A. Zulkepli
L.J. Fay
R.A. Wahab
E.M. Arief
author_facet A. Seeni
N.A. Zulkepli
L.J. Fay
R.A. Wahab
E.M. Arief
author_sort A. Seeni
title Ca-Cleanse: Herbal Mouthwash for Oral Cancer Prevention
title_short Ca-Cleanse: Herbal Mouthwash for Oral Cancer Prevention
title_full Ca-Cleanse: Herbal Mouthwash for Oral Cancer Prevention
title_fullStr Ca-Cleanse: Herbal Mouthwash for Oral Cancer Prevention
title_full_unstemmed Ca-Cleanse: Herbal Mouthwash for Oral Cancer Prevention
title_sort ca-cleanse: herbal mouthwash for oral cancer prevention
publishDate 2012
url http://ddms.usim.edu.my/handle/123456789/6115
_version_ 1645151810404483072
score 13.222552

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