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Anti-quorum Sensing Activity of Local Ulam in Malaysia

Bacterial intercellular communication, or quorum sensing (QS), controls the pathogenesis of many medically important organisms. Anti-QS compounds have the ability to attenuate bacterial pathogenicity. Therefore, recent research has focused on the development of therapeutic agents which prevent ba...

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Main Authors: M.Z. Mohd Shaman, A. Mohd Fikri, A.W. Nur Aishah, M.R. Salina, M.N. Hanina
Format: Conference Paper
Language:English
Published: 2012
Subjects:
Anti-Quarum sensing (Anti-QS)
Chromobacterium violaceum
Therapeutic
Pathogenicity
Ulam
Online Access:http://ddms.usim.edu.my/handle/123456789/6110
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spelling my.usim-61102015-07-03T00:37:11Z Anti-quorum Sensing Activity of Local Ulam in Malaysia M.Z. Mohd Shaman A. Mohd Fikri A.W. Nur Aishah M.R. Salina M.N. Hanina Anti-Quarum sensing (Anti-QS) Chromobacterium violaceum Therapeutic Pathogenicity Ulam Bacterial intercellular communication, or quorum sensing (QS), controls the pathogenesis of many medically important organisms. Anti-QS compounds have the ability to attenuate bacterial pathogenicity. Therefore, recent research has focused on the development of therapeutic agents which prevent bacterial pathogenesis by inhibiting bacterial QS. The current quest for new antimicrobials aimed at discovering non-toxic inhibitors of QS from natural sources which can be used for treatment of bacterial infections in human. The primary objective of this research is to identify QS inhibitors or anti-QS compounds in some of local ulam commonly found in Malaysia. In this study, plants were collected and tested using biomonitor strain, Chromobacterium violaceum. This biomonitor strain has an ability to produce a purple pigment (violacein) under QS-control. To test this hypothesis, 5 types of local ulam, including Parkia speciosa (petai or bitter bean), Cosmos cardatus (Ulam raja), Centella asiatica (pegaga), Ocimum sanctum (selasih) and Psophocarpus tetragonolobus (kacang botol) were screened for anti-QS activity using two biomonitor strains of Chromobacterium violaceum, ATCC 12472 and ATCC 31532. Among these plants, only Parkia speciosa obviously showed QS inhibition. This study introduces not only a new mode of action and possible validation for traditional plant use, but also a potentially new therapeutic direction for the treatment of bacterial infections. 2012-12-31T04:26:05Z 2012-12-31T04:26:05Z 2012-12-31 Conference Paper http://ddms.usim.edu.my/handle/123456789/6110 en
institution Universiti Sains Islam Malaysia
building USIM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universit Sains Islam i Malaysia
content_source USIM Institutional Repository
url_provider http://ddms.usim.edu.my/
language English
topic Anti-Quarum sensing (Anti-QS)
Chromobacterium violaceum
Therapeutic
Pathogenicity
Ulam
spellingShingle Anti-Quarum sensing (Anti-QS)
Chromobacterium violaceum
Therapeutic
Pathogenicity
Ulam
M.Z. Mohd Shaman
A. Mohd Fikri
A.W. Nur Aishah
M.R. Salina
M.N. Hanina
Anti-quorum Sensing Activity of Local Ulam in Malaysia
description Bacterial intercellular communication, or quorum sensing (QS), controls the pathogenesis of many medically important organisms. Anti-QS compounds have the ability to attenuate bacterial pathogenicity. Therefore, recent research has focused on the development of therapeutic agents which prevent bacterial pathogenesis by inhibiting bacterial QS. The current quest for new antimicrobials aimed at discovering non-toxic inhibitors of QS from natural sources which can be used for treatment of bacterial infections in human. The primary objective of this research is to identify QS inhibitors or anti-QS compounds in some of local ulam commonly found in Malaysia. In this study, plants were collected and tested using biomonitor strain, Chromobacterium violaceum. This biomonitor strain has an ability to produce a purple pigment (violacein) under QS-control. To test this hypothesis, 5 types of local ulam, including Parkia speciosa (petai or bitter bean), Cosmos cardatus (Ulam raja), Centella asiatica (pegaga), Ocimum sanctum (selasih) and Psophocarpus tetragonolobus (kacang botol) were screened for anti-QS activity using two biomonitor strains of Chromobacterium violaceum, ATCC 12472 and ATCC 31532. Among these plants, only Parkia speciosa obviously showed QS inhibition. This study introduces not only a new mode of action and possible validation for traditional plant use, but also a potentially new therapeutic direction for the treatment of bacterial infections.
format Conference Paper
author M.Z. Mohd Shaman
A. Mohd Fikri
A.W. Nur Aishah
M.R. Salina
M.N. Hanina
author_facet M.Z. Mohd Shaman
A. Mohd Fikri
A.W. Nur Aishah
M.R. Salina
M.N. Hanina
author_sort M.Z. Mohd Shaman
title Anti-quorum Sensing Activity of Local Ulam in Malaysia
title_short Anti-quorum Sensing Activity of Local Ulam in Malaysia
title_full Anti-quorum Sensing Activity of Local Ulam in Malaysia
title_fullStr Anti-quorum Sensing Activity of Local Ulam in Malaysia
title_full_unstemmed Anti-quorum Sensing Activity of Local Ulam in Malaysia
title_sort anti-quorum sensing activity of local ulam in malaysia
publishDate 2012
url http://ddms.usim.edu.my/handle/123456789/6110
_version_ 1645151808934379520
score 13.222552

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