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A case of angiomatoid epithelioid sarcoma mimicking an epithelioid vascular neoplasm

Epithelioid sarcoma is a rare but aggressive soft tissue sarcoma that presents a significant diagnostic and manage- ment challenge to clinicians. We report a 31-year-old female who presented with a non-healing ulcer of three years’ duration on her left thumb after a burn. Examination revealed an ulc...

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Main Authors: Lai, Shau Kong, Tan, Ling Tze, Tan, Lii Jye, Koh, Cai Ping, Yahaya, Balqis, Hussin, Huzlinda
Format: Article
Language:English
Published: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2022
Online Access:http://psasir.upm.edu.my/id/eprint/99319/1/2022121912513218_MJMHS_0388.pdf
http://psasir.upm.edu.my/id/eprint/99319/
https://medic.upm.edu.my/upload/dokumen/2022121912513218_MJMHS_0388.pdf
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spelling my.upm.eprints.993192023-03-09T03:30:13Z http://psasir.upm.edu.my/id/eprint/99319/ A case of angiomatoid epithelioid sarcoma mimicking an epithelioid vascular neoplasm Lai, Shau Kong Tan, Ling Tze Tan, Lii Jye Koh, Cai Ping Yahaya, Balqis Hussin, Huzlinda Epithelioid sarcoma is a rare but aggressive soft tissue sarcoma that presents a significant diagnostic and manage- ment challenge to clinicians. We report a 31-year-old female who presented with a non-healing ulcer of three years’ duration on her left thumb after a burn. Examination revealed an ulcerative tumour invading the bone with areas of haemorrhage. Microscopic examination showed an epithelioid neoplasm with central necrosis. The neoplastic cells formed dyscohesive sheets, slit-like channels, and pseudovascular spaces. Erythrocytes were frequently observed in these areas. The neoplastic malignant cells were diffusely positive for cytokeratin AE1/AE3, EMA, vimentin, Fli-1; while focally positive for CD34 and CD31. The morphology and immunophenotype overlap with a vascular neo- plasm. Additional immunohistochemical stain revealed loss of SMARCB1/INI1 expression supporting the diagnosis of epithelioid sarcoma of distal type, angiomatoid variant. We present a distinctive case of angiomatoid epithelioid sarcoma that developed in a burn ulcer and highlight pathological characteristics that distinguish it from epithelioid vascular neoplasms. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2022-12 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/99319/1/2022121912513218_MJMHS_0388.pdf Lai, Shau Kong and Tan, Ling Tze and Tan, Lii Jye and Koh, Cai Ping and Yahaya, Balqis and Hussin, Huzlinda (2022) A case of angiomatoid epithelioid sarcoma mimicking an epithelioid vascular neoplasm. Malaysian Journal of Medicine and Health Sciences, 18 (supp.21). pp. 122-125. ISSN 2636-9346 https://medic.upm.edu.my/upload/dokumen/2022121912513218_MJMHS_0388.pdf 10.47836/mjmhs18.s21.19
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Epithelioid sarcoma is a rare but aggressive soft tissue sarcoma that presents a significant diagnostic and manage- ment challenge to clinicians. We report a 31-year-old female who presented with a non-healing ulcer of three years’ duration on her left thumb after a burn. Examination revealed an ulcerative tumour invading the bone with areas of haemorrhage. Microscopic examination showed an epithelioid neoplasm with central necrosis. The neoplastic cells formed dyscohesive sheets, slit-like channels, and pseudovascular spaces. Erythrocytes were frequently observed in these areas. The neoplastic malignant cells were diffusely positive for cytokeratin AE1/AE3, EMA, vimentin, Fli-1; while focally positive for CD34 and CD31. The morphology and immunophenotype overlap with a vascular neo- plasm. Additional immunohistochemical stain revealed loss of SMARCB1/INI1 expression supporting the diagnosis of epithelioid sarcoma of distal type, angiomatoid variant. We present a distinctive case of angiomatoid epithelioid sarcoma that developed in a burn ulcer and highlight pathological characteristics that distinguish it from epithelioid vascular neoplasms.
format Article
author Lai, Shau Kong
Tan, Ling Tze
Tan, Lii Jye
Koh, Cai Ping
Yahaya, Balqis
Hussin, Huzlinda
spellingShingle Lai, Shau Kong
Tan, Ling Tze
Tan, Lii Jye
Koh, Cai Ping
Yahaya, Balqis
Hussin, Huzlinda
A case of angiomatoid epithelioid sarcoma mimicking an epithelioid vascular neoplasm
author_facet Lai, Shau Kong
Tan, Ling Tze
Tan, Lii Jye
Koh, Cai Ping
Yahaya, Balqis
Hussin, Huzlinda
author_sort Lai, Shau Kong
title A case of angiomatoid epithelioid sarcoma mimicking an epithelioid vascular neoplasm
title_short A case of angiomatoid epithelioid sarcoma mimicking an epithelioid vascular neoplasm
title_full A case of angiomatoid epithelioid sarcoma mimicking an epithelioid vascular neoplasm
title_fullStr A case of angiomatoid epithelioid sarcoma mimicking an epithelioid vascular neoplasm
title_full_unstemmed A case of angiomatoid epithelioid sarcoma mimicking an epithelioid vascular neoplasm
title_sort case of angiomatoid epithelioid sarcoma mimicking an epithelioid vascular neoplasm
publisher Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
publishDate 2022
url http://psasir.upm.edu.my/id/eprint/99319/1/2022121912513218_MJMHS_0388.pdf
http://psasir.upm.edu.my/id/eprint/99319/
https://medic.upm.edu.my/upload/dokumen/2022121912513218_MJMHS_0388.pdf
_version_ 1761620386686959616
score 13.211869

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