Staff View: Vitamin D levels and steroid usage are not associated with disease activity in systemic lupus erythematosus patients

Vitamin D levels and steroid usage are not associated with disease activity in systemic lupus erythematosus patients

Introduction: Suboptimal vitamin D levels are commonly presented by systemic lupus erythemathosus (SLE) patients. This is likely due to protection measures from sunshine exposure adopted by SLE patients to reduce the likelihood of SLE flares onset. In this study, we investigated the vitamin D level...

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Main Authors:	Ibrahim, Izzaidah, Wan Mohamed, Wan Mohd Izani, Kah, Keng Wong, Tuan Ismail, Tuan Salwani, Wan Ghazali, Wan Syamimee
Format:	Article
Language:	English
Published:	Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2022
Online Access:	http://psasir.upm.edu.my/id/eprint/98128/1/2022031418332104_MJMHS_0766.pdf http://psasir.upm.edu.my/id/eprint/98128/ https://medic.upm.edu.my/upload/dokumen/2022031418332104_MJMHS_0766.pdf
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spelling	my.upm.eprints.981282022-08-11T08:29:11Z http://psasir.upm.edu.my/id/eprint/98128/ Vitamin D levels and steroid usage are not associated with disease activity in systemic lupus erythematosus patients Ibrahim, Izzaidah Wan Mohamed, Wan Mohd Izani Kah, Keng Wong Tuan Ismail, Tuan Salwani Wan Ghazali, Wan Syamimee Introduction: Suboptimal vitamin D levels are commonly presented by systemic lupus erythemathosus (SLE) patients. This is likely due to protection measures from sunshine exposure adopted by SLE patients to reduce the likelihood of SLE flares onset. In this study, we investigated the vitamin D level among SLE patients and its association with SLE Disease Activity (SLEDAI) scores and among groups of steroid and non-steroid usage. Methods: We recruited 84 SLE patients who attended the Rheumatology Clinic of Hospital Universiti Sains Malaysia from June 2018 until October 2018. Their clinico-demographic data were retrieved and serum vitamin D immunoassay was conducted to measure the vitamin D levels of each patient Vitamin D levels were categorized as normal (≥75nmol/L), insufficient (50-74 nmol/L) or deficient (<50 nmol/L). Comparison between the clinico-demographic parameters with vitamin D levels were conducted using the Fisher’s exact test (for categorical variables) and unpaired t-test (for continuous variables). Results: The mean vitamin D level among the subjects was 40.79 ± 20.2 nmol/L. Fifty-eight (69%) patients were vitamin D deficient, while 20 (23.8%) patients were vitamin D insufficient, and only 6 (7.1%) patients had sufficient level of vitamin D. Vitamin D status was not significantly associated with SLEDAI score (p=0.185) as well as between steroids and non-steroids groups (p=0.255). Conclusion: Vitamin D deficiency occurred in majority of our SLE patients. SLE disease activities were not associated with the status of vitamin D or steroid usage. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2022-03 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/98128/1/2022031418332104_MJMHS_0766.pdf Ibrahim, Izzaidah and Wan Mohamed, Wan Mohd Izani and Kah, Keng Wong and Tuan Ismail, Tuan Salwani and Wan Ghazali, Wan Syamimee (2022) Vitamin D levels and steroid usage are not associated with disease activity in systemic lupus erythematosus patients. Malaysian Journal of Medicine and Health Sciences, 18 (2). pp. 20-25. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2022031418332104_MJMHS_0766.pdf
institution	Universiti Putra Malaysia
building	UPM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Putra Malaysia
content_source	UPM Institutional Repository
url_provider	http://psasir.upm.edu.my/
language	English
description	Introduction: Suboptimal vitamin D levels are commonly presented by systemic lupus erythemathosus (SLE) patients. This is likely due to protection measures from sunshine exposure adopted by SLE patients to reduce the likelihood of SLE flares onset. In this study, we investigated the vitamin D level among SLE patients and its association with SLE Disease Activity (SLEDAI) scores and among groups of steroid and non-steroid usage. Methods: We recruited 84 SLE patients who attended the Rheumatology Clinic of Hospital Universiti Sains Malaysia from June 2018 until October 2018. Their clinico-demographic data were retrieved and serum vitamin D immunoassay was conducted to measure the vitamin D levels of each patient Vitamin D levels were categorized as normal (≥75nmol/L), insufficient (50-74 nmol/L) or deficient (<50 nmol/L). Comparison between the clinico-demographic parameters with vitamin D levels were conducted using the Fisher’s exact test (for categorical variables) and unpaired t-test (for continuous variables). Results: The mean vitamin D level among the subjects was 40.79 ± 20.2 nmol/L. Fifty-eight (69%) patients were vitamin D deficient, while 20 (23.8%) patients were vitamin D insufficient, and only 6 (7.1%) patients had sufficient level of vitamin D. Vitamin D status was not significantly associated with SLEDAI score (p=0.185) as well as between steroids and non-steroids groups (p=0.255). Conclusion: Vitamin D deficiency occurred in majority of our SLE patients. SLE disease activities were not associated with the status of vitamin D or steroid usage.
format	Article
author	Ibrahim, Izzaidah Wan Mohamed, Wan Mohd Izani Kah, Keng Wong Tuan Ismail, Tuan Salwani Wan Ghazali, Wan Syamimee
spellingShingle	Ibrahim, Izzaidah Wan Mohamed, Wan Mohd Izani Kah, Keng Wong Tuan Ismail, Tuan Salwani Wan Ghazali, Wan Syamimee Vitamin D levels and steroid usage are not associated with disease activity in systemic lupus erythematosus patients
author_facet	Ibrahim, Izzaidah Wan Mohamed, Wan Mohd Izani Kah, Keng Wong Tuan Ismail, Tuan Salwani Wan Ghazali, Wan Syamimee
author_sort	Ibrahim, Izzaidah
title	Vitamin D levels and steroid usage are not associated with disease activity in systemic lupus erythematosus patients
title_short	Vitamin D levels and steroid usage are not associated with disease activity in systemic lupus erythematosus patients
title_full	Vitamin D levels and steroid usage are not associated with disease activity in systemic lupus erythematosus patients
title_fullStr	Vitamin D levels and steroid usage are not associated with disease activity in systemic lupus erythematosus patients
title_full_unstemmed	Vitamin D levels and steroid usage are not associated with disease activity in systemic lupus erythematosus patients
title_sort	vitamin d levels and steroid usage are not associated with disease activity in systemic lupus erythematosus patients
publisher	Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
publishDate	2022
url	http://psasir.upm.edu.my/id/eprint/98128/1/2022031418332104_MJMHS_0766.pdf http://psasir.upm.edu.my/id/eprint/98128/ https://medic.upm.edu.my/upload/dokumen/2022031418332104_MJMHS_0766.pdf
_version_	1743108555880267776
score	13.211869

Vitamin D levels and steroid usage are not associated with disease activity in systemic lupus erythematosus patients

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