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Association of T2 mapping of knee cartilage with age, gender & BMI among young adults attending Pusat Pengimejan Diagnostik Nucklear (PPDN), Universiti Putra Malaysia

According to World Health Organization, osteoarthritis (OA) is defined as a long-term chronic disease characterized by deterioration of joints cartilage as a sequelae of degenerative changes causing stiffness, pain and impaired mobility. The disease most commonly affects the joints in the knees, han...

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Main Author: Soo, Tze Hui
Format: Thesis
Language:English
Published: 2021
Subjects:
Cartilage Diseases
Online Access:http://psasir.upm.edu.my/id/eprint/97957/1/FPSK%20%28m%29%202021%2036%20IR.pdf
http://psasir.upm.edu.my/id/eprint/97957/
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spelling my.upm.eprints.979572022-07-13T07:59:40Z http://psasir.upm.edu.my/id/eprint/97957/ Association of T2 mapping of knee cartilage with age, gender & BMI among young adults attending Pusat Pengimejan Diagnostik Nucklear (PPDN), Universiti Putra Malaysia Soo, Tze Hui According to World Health Organization, osteoarthritis (OA) is defined as a long-term chronic disease characterized by deterioration of joints cartilage as a sequelae of degenerative changes causing stiffness, pain and impaired mobility. The disease most commonly affects the joints in the knees, hands, feet, and spine and is relatively common in shoulder and hip joints. The prevalence of knee OA in Malaysia was estimated to be 10% to 20% of the elderly population and more common in adults aged 40 years and above. Self-regeneration processes are only initiated when damage reaches the subchondral bones. Sudden and rapid applied excessive force would not allow for sufficient fluid to move through the matrix for shock absorption, thus allowing the stress to be applied fully on the macromolecules network causing micro tears and matrix injury. In severe cases, there might be segmental loss of cartilage. Macromolecules synthesized by chondrocytes are inadequate to fill the gaps caused by injuries. By times, OA start to set in causing chronic pain and instability. MRI is the only imaging of choice that able to provide structural details as well as biochemical information about the articular cartilage. Moreover, it would be desirable for MRI to provide an evaluation of the underlying cartilage physiology including providing information about the status of prostaglandins (PGs) and collagen matrices. T2 mapping is straightforward to perform and is sensitive to changes in collagen as well as water content, but less sensitive in detection of early degeneration. A retrospective and prospective cross sectional study using secondary and primary data to provide information on the value of T2 mapping of knee articular cartilage (medial and lateral compartment) in asymptomatic young adult and its association with gender, age and body mass index was carried out over a period of 2 years from December 2018 to December 2020. The data was then post processed with T2 mapping programming via Matlab R2019b version and further analysed with SPSS version 26. Overall, we has shown that female has slightly higher mean T2 value (49.1731ms to 51.9192ms) as compared to male population (48.4147ms to 49.4647ms) out of 30 volunteers recruited. We concluded that as we age, the T2 value increases which signify the occurrence of OA has set in slowly. In our study, T2 value increases as BMI increase as well. With 3 independent variables tested, our result were consistent with previous studies even though there was no strong association ( p > 0.05) obtained. 2021-05 Thesis NonPeerReviewed text en http://psasir.upm.edu.my/id/eprint/97957/1/FPSK%20%28m%29%202021%2036%20IR.pdf Soo, Tze Hui (2021) Association of T2 mapping of knee cartilage with age, gender & BMI among young adults attending Pusat Pengimejan Diagnostik Nucklear (PPDN), Universiti Putra Malaysia. Masters thesis, Universiti Putra Malaysia. Cartilage Diseases
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
topic Cartilage Diseases
spellingShingle Cartilage Diseases
Soo, Tze Hui
Association of T2 mapping of knee cartilage with age, gender & BMI among young adults attending Pusat Pengimejan Diagnostik Nucklear (PPDN), Universiti Putra Malaysia
description According to World Health Organization, osteoarthritis (OA) is defined as a long-term chronic disease characterized by deterioration of joints cartilage as a sequelae of degenerative changes causing stiffness, pain and impaired mobility. The disease most commonly affects the joints in the knees, hands, feet, and spine and is relatively common in shoulder and hip joints. The prevalence of knee OA in Malaysia was estimated to be 10% to 20% of the elderly population and more common in adults aged 40 years and above. Self-regeneration processes are only initiated when damage reaches the subchondral bones. Sudden and rapid applied excessive force would not allow for sufficient fluid to move through the matrix for shock absorption, thus allowing the stress to be applied fully on the macromolecules network causing micro tears and matrix injury. In severe cases, there might be segmental loss of cartilage. Macromolecules synthesized by chondrocytes are inadequate to fill the gaps caused by injuries. By times, OA start to set in causing chronic pain and instability. MRI is the only imaging of choice that able to provide structural details as well as biochemical information about the articular cartilage. Moreover, it would be desirable for MRI to provide an evaluation of the underlying cartilage physiology including providing information about the status of prostaglandins (PGs) and collagen matrices. T2 mapping is straightforward to perform and is sensitive to changes in collagen as well as water content, but less sensitive in detection of early degeneration. A retrospective and prospective cross sectional study using secondary and primary data to provide information on the value of T2 mapping of knee articular cartilage (medial and lateral compartment) in asymptomatic young adult and its association with gender, age and body mass index was carried out over a period of 2 years from December 2018 to December 2020. The data was then post processed with T2 mapping programming via Matlab R2019b version and further analysed with SPSS version 26. Overall, we has shown that female has slightly higher mean T2 value (49.1731ms to 51.9192ms) as compared to male population (48.4147ms to 49.4647ms) out of 30 volunteers recruited. We concluded that as we age, the T2 value increases which signify the occurrence of OA has set in slowly. In our study, T2 value increases as BMI increase as well. With 3 independent variables tested, our result were consistent with previous studies even though there was no strong association ( p > 0.05) obtained.
format Thesis
author Soo, Tze Hui
author_facet Soo, Tze Hui
author_sort Soo, Tze Hui
title Association of T2 mapping of knee cartilage with age, gender & BMI among young adults attending Pusat Pengimejan Diagnostik Nucklear (PPDN), Universiti Putra Malaysia
title_short Association of T2 mapping of knee cartilage with age, gender & BMI among young adults attending Pusat Pengimejan Diagnostik Nucklear (PPDN), Universiti Putra Malaysia
title_full Association of T2 mapping of knee cartilage with age, gender & BMI among young adults attending Pusat Pengimejan Diagnostik Nucklear (PPDN), Universiti Putra Malaysia
title_fullStr Association of T2 mapping of knee cartilage with age, gender & BMI among young adults attending Pusat Pengimejan Diagnostik Nucklear (PPDN), Universiti Putra Malaysia
title_full_unstemmed Association of T2 mapping of knee cartilage with age, gender & BMI among young adults attending Pusat Pengimejan Diagnostik Nucklear (PPDN), Universiti Putra Malaysia
title_sort association of t2 mapping of knee cartilage with age, gender & bmi among young adults attending pusat pengimejan diagnostik nucklear (ppdn), universiti putra malaysia
publishDate 2021
url http://psasir.upm.edu.my/id/eprint/97957/1/FPSK%20%28m%29%202021%2036%20IR.pdf
http://psasir.upm.edu.my/id/eprint/97957/
_version_ 1738512024604770304
score 13.222552

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