Staff View: Histopathological changes in the reproductive organs of does with pregnancy toxaemia and their aborted foetuses

Histopathological changes in the reproductive organs of does with pregnancy toxaemia and their aborted foetuses

Pregnancy toxaemia (PT) is a metabolic disorder affecting does during late gestation. This study describes the histopathological changes in pregnant does and their foetuses experimentally-induced with PT. Eight does in their late pregnancy were induced into PT by reducing the energy intake (Group 1)...

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Main Authors:	Zainal Ulum, Muhamad Taqiyudin, Ab Azid, Muhamad Affan, Shen, Tong Wei, Hassim, Hasliza Abu, Zamri-Saad, Mohd, Salleh, Annas
Format:	Article
Published:	Elsevier BV 2021
Online Access:	http://psasir.upm.edu.my/id/eprint/97534/ https://www.sciencedirect.com/science/article/pii/S0921448821000481
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spelling	my.upm.eprints.975342024-05-20T04:18:34Z http://psasir.upm.edu.my/id/eprint/97534/ Histopathological changes in the reproductive organs of does with pregnancy toxaemia and their aborted foetuses Zainal Ulum, Muhamad Taqiyudin Ab Azid, Muhamad Affan Shen, Tong Wei Hassim, Hasliza Abu Zamri-Saad, Mohd Salleh, Annas Pregnancy toxaemia (PT) is a metabolic disorder affecting does during late gestation. This study describes the histopathological changes in pregnant does and their foetuses experimentally-induced with PT. Eight does in their late pregnancy were induced into PT by reducing the energy intake (Group 1), while 6 does were maintained with adequate energy intake (Group 2). The blood beta-hydroxybutyric acid (BHBA) and glucose concentrations were measured every 5 days throughout the 20-day study period. All does that experienced stillbirth were immediately euthanised, while the does and the full-term, non-aborted foetuses were euthanised on day 20. Samples of umbilical cords, placentas and uteri were collected from the does, while hearts and livers were collected from the foetuses. The samples were subjected to histopathological assessment, and subsequently correlated with the blood BHBA concentration. Stillbirth occurred in 5 (62.5 %) does of Group 1. The remaining does of Group 1 and all does of Group 2 did not experience stillbirth until the end of the experiment. Overall lesions in the umbilical cord were significantly (p < 0.01) more severe in Group 1. Does of Group 1 that experienced stillbirth showed chorionic villi necrosis and homogenous chorionic villi hypomaturity, while the endometrial glands were non-secreting. The stillborn foetuses showed extensive hepatic necrosis. The last concentrations of BHBA and glucose showed significant (p < 0.05) difference between the two groups. The histopathological lesions in the placenta, uterus, and foetal liver were significantly (p < 0.05−0.01) correlated with the blood BHBA concentration. The histopathology lesions could suggest the mechanism of stillbirth in PT and raise concern that it could affect the performance of the off-springs should stillbirth did not occur. Elsevier BV 2021-06 Article PeerReviewed Zainal Ulum, Muhamad Taqiyudin and Ab Azid, Muhamad Affan and Shen, Tong Wei and Hassim, Hasliza Abu and Zamri-Saad, Mohd and Salleh, Annas (2021) Histopathological changes in the reproductive organs of does with pregnancy toxaemia and their aborted foetuses. Small Ruminant Research, 199. art. no. 106363. pp. 1-6. ISSN 0921-4488 https://www.sciencedirect.com/science/article/pii/S0921448821000481 10.1016/j.smallrumres.2021.106363
institution	Universiti Putra Malaysia
building	UPM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Putra Malaysia
content_source	UPM Institutional Repository
url_provider	http://psasir.upm.edu.my/
description	Pregnancy toxaemia (PT) is a metabolic disorder affecting does during late gestation. This study describes the histopathological changes in pregnant does and their foetuses experimentally-induced with PT. Eight does in their late pregnancy were induced into PT by reducing the energy intake (Group 1), while 6 does were maintained with adequate energy intake (Group 2). The blood beta-hydroxybutyric acid (BHBA) and glucose concentrations were measured every 5 days throughout the 20-day study period. All does that experienced stillbirth were immediately euthanised, while the does and the full-term, non-aborted foetuses were euthanised on day 20. Samples of umbilical cords, placentas and uteri were collected from the does, while hearts and livers were collected from the foetuses. The samples were subjected to histopathological assessment, and subsequently correlated with the blood BHBA concentration. Stillbirth occurred in 5 (62.5 %) does of Group 1. The remaining does of Group 1 and all does of Group 2 did not experience stillbirth until the end of the experiment. Overall lesions in the umbilical cord were significantly (p < 0.01) more severe in Group 1. Does of Group 1 that experienced stillbirth showed chorionic villi necrosis and homogenous chorionic villi hypomaturity, while the endometrial glands were non-secreting. The stillborn foetuses showed extensive hepatic necrosis. The last concentrations of BHBA and glucose showed significant (p < 0.05) difference between the two groups. The histopathological lesions in the placenta, uterus, and foetal liver were significantly (p < 0.05−0.01) correlated with the blood BHBA concentration. The histopathology lesions could suggest the mechanism of stillbirth in PT and raise concern that it could affect the performance of the off-springs should stillbirth did not occur.
format	Article
author	Zainal Ulum, Muhamad Taqiyudin Ab Azid, Muhamad Affan Shen, Tong Wei Hassim, Hasliza Abu Zamri-Saad, Mohd Salleh, Annas
spellingShingle	Zainal Ulum, Muhamad Taqiyudin Ab Azid, Muhamad Affan Shen, Tong Wei Hassim, Hasliza Abu Zamri-Saad, Mohd Salleh, Annas Histopathological changes in the reproductive organs of does with pregnancy toxaemia and their aborted foetuses
author_facet	Zainal Ulum, Muhamad Taqiyudin Ab Azid, Muhamad Affan Shen, Tong Wei Hassim, Hasliza Abu Zamri-Saad, Mohd Salleh, Annas
author_sort	Zainal Ulum, Muhamad Taqiyudin
title	Histopathological changes in the reproductive organs of does with pregnancy toxaemia and their aborted foetuses
title_short	Histopathological changes in the reproductive organs of does with pregnancy toxaemia and their aborted foetuses
title_full	Histopathological changes in the reproductive organs of does with pregnancy toxaemia and their aborted foetuses
title_fullStr	Histopathological changes in the reproductive organs of does with pregnancy toxaemia and their aborted foetuses
title_full_unstemmed	Histopathological changes in the reproductive organs of does with pregnancy toxaemia and their aborted foetuses
title_sort	histopathological changes in the reproductive organs of does with pregnancy toxaemia and their aborted foetuses
publisher	Elsevier BV
publishDate	2021
url	http://psasir.upm.edu.my/id/eprint/97534/ https://www.sciencedirect.com/science/article/pii/S0921448821000481
_version_	1800093843970850816
score	13.211869

Histopathological changes in the reproductive organs of does with pregnancy toxaemia and their aborted foetuses

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