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High early pregnancy serum 25-hydroxy vitamin D level, within a sub-optimal range, is associated with gestational diabetes mellitus: a prospective cohort study

Background/objectives: Low early pregnancy serum 25-hydroxy vitamin D (25[OH]D) levels can increase gestational diabetes mellitus (GDM) risk, although inconsistent findings related to that association have been reported. This study examined the association of serum vitamin D with GDM and the possibl...

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Main Authors: Yong, Heng Yaw, Mohd Shariff, Zalilah, Palaniveloo, Lalitha, Loh, Su Peng, Mohd Yusof, Barakatun Nisak, Rejali, Zulida, Bindels, Jacques, Yee, Yvonne Siang Tee, van der Beek, Eline M.
Format: Article
Language:English
Published: The Korean Society of Community Nutrition 2021
Online Access:http://psasir.upm.edu.my/id/eprint/97521/1/ABSTRACT.pdf
http://psasir.upm.edu.my/id/eprint/97521/
https://e-nrp.org/DOIx.php?id=10.4162/nrp.2022.16.1.120
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spelling my.upm.eprints.975212022-07-27T06:21:39Z http://psasir.upm.edu.my/id/eprint/97521/ High early pregnancy serum 25-hydroxy vitamin D level, within a sub-optimal range, is associated with gestational diabetes mellitus: a prospective cohort study Yong, Heng Yaw Mohd Shariff, Zalilah Palaniveloo, Lalitha Loh, Su Peng Mohd Yusof, Barakatun Nisak Rejali, Zulida Bindels, Jacques Yee, Yvonne Siang Tee van der Beek, Eline M. Background/objectives: Low early pregnancy serum 25-hydroxy vitamin D (25[OH]D) levels can increase gestational diabetes mellitus (GDM) risk, although inconsistent findings related to that association have been reported. This study examined the association of serum vitamin D with GDM and the possible influencers on this association. Subjects/methods: This study included 259 pregnant women within the Seremban Cohort Study (SECOST). Blood samples at < 14 weeks of gestation were drawn to determine serum 25(OH)D levels. GDM diagnosis was made at 24 to 32 weeks of gestation using a standard procedure. Association between serum vitamin D and GDM was tested using binary logistic regression. Results: Nearly all women (90%) had mild (68.3%) or severe (32.2%) vitamin D deficiency (VDD). Non-GDM women with mild VDD had a significantly higher mean vitamin D intake than GDM women with mild VDD (t = 2.04, p < 0.05). Women with higher early pregnancy serum vitamin D levels had a greater risk of GDM. However, this significant association was only identified among those with a family history of type 2 diabetes mellitus (T2DM) and in women with a body mass index indicating overweight or obese status. Conclusions: The high prevalence of VDD in this sample of pregnant women underscores the need for effective preventive public health strategies. Further investigation of this unexpected association between serum vitamin D level and GDM risk in predominantly VDD pregnant women and the potential effects of adiposity and family history of T2DM on that association is warranted. The Korean Society of Community Nutrition 2021 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/97521/1/ABSTRACT.pdf Yong, Heng Yaw and Mohd Shariff, Zalilah and Palaniveloo, Lalitha and Loh, Su Peng and Mohd Yusof, Barakatun Nisak and Rejali, Zulida and Bindels, Jacques and Yee, Yvonne Siang Tee and van der Beek, Eline M. (2021) High early pregnancy serum 25-hydroxy vitamin D level, within a sub-optimal range, is associated with gestational diabetes mellitus: a prospective cohort study. Nutrition Research and Practice, 16 (1). pp. 120-131. ISSN 1976-1457; ESSN: 2005-6168 https://e-nrp.org/DOIx.php?id=10.4162/nrp.2022.16.1.120 10.4162/nrp.2022.16.1.120
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Background/objectives: Low early pregnancy serum 25-hydroxy vitamin D (25[OH]D) levels can increase gestational diabetes mellitus (GDM) risk, although inconsistent findings related to that association have been reported. This study examined the association of serum vitamin D with GDM and the possible influencers on this association. Subjects/methods: This study included 259 pregnant women within the Seremban Cohort Study (SECOST). Blood samples at < 14 weeks of gestation were drawn to determine serum 25(OH)D levels. GDM diagnosis was made at 24 to 32 weeks of gestation using a standard procedure. Association between serum vitamin D and GDM was tested using binary logistic regression. Results: Nearly all women (90%) had mild (68.3%) or severe (32.2%) vitamin D deficiency (VDD). Non-GDM women with mild VDD had a significantly higher mean vitamin D intake than GDM women with mild VDD (t = 2.04, p < 0.05). Women with higher early pregnancy serum vitamin D levels had a greater risk of GDM. However, this significant association was only identified among those with a family history of type 2 diabetes mellitus (T2DM) and in women with a body mass index indicating overweight or obese status. Conclusions: The high prevalence of VDD in this sample of pregnant women underscores the need for effective preventive public health strategies. Further investigation of this unexpected association between serum vitamin D level and GDM risk in predominantly VDD pregnant women and the potential effects of adiposity and family history of T2DM on that association is warranted.
format Article
author Yong, Heng Yaw
Mohd Shariff, Zalilah
Palaniveloo, Lalitha
Loh, Su Peng
Mohd Yusof, Barakatun Nisak
Rejali, Zulida
Bindels, Jacques
Yee, Yvonne Siang Tee
van der Beek, Eline M.
spellingShingle Yong, Heng Yaw
Mohd Shariff, Zalilah
Palaniveloo, Lalitha
Loh, Su Peng
Mohd Yusof, Barakatun Nisak
Rejali, Zulida
Bindels, Jacques
Yee, Yvonne Siang Tee
van der Beek, Eline M.
High early pregnancy serum 25-hydroxy vitamin D level, within a sub-optimal range, is associated with gestational diabetes mellitus: a prospective cohort study
author_facet Yong, Heng Yaw
Mohd Shariff, Zalilah
Palaniveloo, Lalitha
Loh, Su Peng
Mohd Yusof, Barakatun Nisak
Rejali, Zulida
Bindels, Jacques
Yee, Yvonne Siang Tee
van der Beek, Eline M.
author_sort Yong, Heng Yaw
title High early pregnancy serum 25-hydroxy vitamin D level, within a sub-optimal range, is associated with gestational diabetes mellitus: a prospective cohort study
title_short High early pregnancy serum 25-hydroxy vitamin D level, within a sub-optimal range, is associated with gestational diabetes mellitus: a prospective cohort study
title_full High early pregnancy serum 25-hydroxy vitamin D level, within a sub-optimal range, is associated with gestational diabetes mellitus: a prospective cohort study
title_fullStr High early pregnancy serum 25-hydroxy vitamin D level, within a sub-optimal range, is associated with gestational diabetes mellitus: a prospective cohort study
title_full_unstemmed High early pregnancy serum 25-hydroxy vitamin D level, within a sub-optimal range, is associated with gestational diabetes mellitus: a prospective cohort study
title_sort high early pregnancy serum 25-hydroxy vitamin d level, within a sub-optimal range, is associated with gestational diabetes mellitus: a prospective cohort study
publisher The Korean Society of Community Nutrition
publishDate 2021
url http://psasir.upm.edu.my/id/eprint/97521/1/ABSTRACT.pdf
http://psasir.upm.edu.my/id/eprint/97521/
https://e-nrp.org/DOIx.php?id=10.4162/nrp.2022.16.1.120
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score 13.211869

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