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Hedgehog signalling molecule, SMO is a poor prognostic marker in bladder cancer

Introduction: Hedgehog (HH) pathway is an important signalling cascade for growth and patterning during embryonic development. Constitutive activation of Hedgehog pathway can be found in various types of malignancies including medulloblastoma, basal cell carcinoma, gastrointestinal, breast, pancreat...

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Main Authors: Mohd Ariffin, Khairunnisa, Abd Ghani, Fauzah, Hussin, Huzlinda, Md Said, Salmiah, Yunus, Rosna, Veerakumarasivam, Abhimanyu, Abdullah, Maizaton Atmadini
Format: Article
Language:English
Published: Malaysian Society of Pathologists 2021
Online Access:http://psasir.upm.edu.my/id/eprint/97513/1/ABSTRACT.pdf
http://psasir.upm.edu.my/id/eprint/97513/
http://www.mjpath.org.my/2021/v43n1/index.php
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spelling my.upm.eprints.975132022-07-27T02:47:50Z http://psasir.upm.edu.my/id/eprint/97513/ Hedgehog signalling molecule, SMO is a poor prognostic marker in bladder cancer Mohd Ariffin, Khairunnisa Abd Ghani, Fauzah Hussin, Huzlinda Md Said, Salmiah Yunus, Rosna Veerakumarasivam, Abhimanyu Abdullah, Maizaton Atmadini Introduction: Hedgehog (HH) pathway is an important signalling cascade for growth and patterning during embryonic development. Constitutive activation of Hedgehog pathway can be found in various types of malignancies including medulloblastoma, basal cell carcinoma, gastrointestinal, breast, pancreatic, prostate cancer and leukaemia. Little is known about the expression and role of Hedgehog signalling in bladder cancer. Materials and methods: The purpose of this study was to investigate the immunohistochemical expression of SMO in 112 bladder cancer cases and determine their association with demographic and clinicopathological parameters. Bladder cancer tissues were obtained from the Hospital Kuala Lumpur. Results: SMO was expressed in the cytoplasm of all cases of bladder cancer. 6 cases (5.4%) showed low expression, while 106 cases (94.6%) showed high expression. Positive expression of SMO protein was correlated with a few variables which include grade and stage of tumour, lymph node metastasis and distant metastasis. SMO expression showed statistically significant association with higher grade (p=0.001) and higher stage (p=0.042) of bladder cancer. SMO expression also showed borderline association with lymph node metastasis (p=0.056). Conclusion: These findings indicate that SMO expression may be a poor prognostic marker in bladder cancer. Malaysian Society of Pathologists 2021 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/97513/1/ABSTRACT.pdf Mohd Ariffin, Khairunnisa and Abd Ghani, Fauzah and Hussin, Huzlinda and Md Said, Salmiah and Yunus, Rosna and Veerakumarasivam, Abhimanyu and Abdullah, Maizaton Atmadini (2021) Hedgehog signalling molecule, SMO is a poor prognostic marker in bladder cancer. Malaysian Journal of Pathology, 43 (1). 49 - 54. ISSN 0126-8635 http://www.mjpath.org.my/2021/v43n1/index.php
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Introduction: Hedgehog (HH) pathway is an important signalling cascade for growth and patterning during embryonic development. Constitutive activation of Hedgehog pathway can be found in various types of malignancies including medulloblastoma, basal cell carcinoma, gastrointestinal, breast, pancreatic, prostate cancer and leukaemia. Little is known about the expression and role of Hedgehog signalling in bladder cancer. Materials and methods: The purpose of this study was to investigate the immunohistochemical expression of SMO in 112 bladder cancer cases and determine their association with demographic and clinicopathological parameters. Bladder cancer tissues were obtained from the Hospital Kuala Lumpur. Results: SMO was expressed in the cytoplasm of all cases of bladder cancer. 6 cases (5.4%) showed low expression, while 106 cases (94.6%) showed high expression. Positive expression of SMO protein was correlated with a few variables which include grade and stage of tumour, lymph node metastasis and distant metastasis. SMO expression showed statistically significant association with higher grade (p=0.001) and higher stage (p=0.042) of bladder cancer. SMO expression also showed borderline association with lymph node metastasis (p=0.056). Conclusion: These findings indicate that SMO expression may be a poor prognostic marker in bladder cancer.
format Article
author Mohd Ariffin, Khairunnisa
Abd Ghani, Fauzah
Hussin, Huzlinda
Md Said, Salmiah
Yunus, Rosna
Veerakumarasivam, Abhimanyu
Abdullah, Maizaton Atmadini
spellingShingle Mohd Ariffin, Khairunnisa
Abd Ghani, Fauzah
Hussin, Huzlinda
Md Said, Salmiah
Yunus, Rosna
Veerakumarasivam, Abhimanyu
Abdullah, Maizaton Atmadini
Hedgehog signalling molecule, SMO is a poor prognostic marker in bladder cancer
author_facet Mohd Ariffin, Khairunnisa
Abd Ghani, Fauzah
Hussin, Huzlinda
Md Said, Salmiah
Yunus, Rosna
Veerakumarasivam, Abhimanyu
Abdullah, Maizaton Atmadini
author_sort Mohd Ariffin, Khairunnisa
title Hedgehog signalling molecule, SMO is a poor prognostic marker in bladder cancer
title_short Hedgehog signalling molecule, SMO is a poor prognostic marker in bladder cancer
title_full Hedgehog signalling molecule, SMO is a poor prognostic marker in bladder cancer
title_fullStr Hedgehog signalling molecule, SMO is a poor prognostic marker in bladder cancer
title_full_unstemmed Hedgehog signalling molecule, SMO is a poor prognostic marker in bladder cancer
title_sort hedgehog signalling molecule, smo is a poor prognostic marker in bladder cancer
publisher Malaysian Society of Pathologists
publishDate 2021
url http://psasir.upm.edu.my/id/eprint/97513/1/ABSTRACT.pdf
http://psasir.upm.edu.my/id/eprint/97513/
http://www.mjpath.org.my/2021/v43n1/index.php
_version_ 1739829907105513472
score 13.211869

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