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Genistein: an integrative overview of its mode of action, pharmacological properties, and health benefits

Genistein is an isoflavone first isolated from the brooming plant Dyer's Genista tinctoria L. and is widely distributed in the Fabaceae family. As an isoflavone, mammalian genistein exerts estrogen-like functions. Several biological effects of genistein have been reported in preclinical studies...

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Main Authors:	Abdull Razis, Ahmad Faizal, Kamal, Ramla Muhammad, Sunusi, Usman, Sharifi-Rad, Javad, Quispe, Cristina, Imran, Muhammad, Rauf, Abdur, Nadeem, Muhammad, Gondal, Tanweer Aslam, Ahmad, Bashir
Format:	Article
Published:	Wiley 2021
Online Access:	http://psasir.upm.edu.my/id/eprint/97437/ https://onlinelibrary.wiley.com/doi/10.1155/2021/3268136
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spelling	my.upm.eprints.974372024-06-19T09:42:18Z http://psasir.upm.edu.my/id/eprint/97437/ Genistein: an integrative overview of its mode of action, pharmacological properties, and health benefits Abdull Razis, Ahmad Faizal Kamal, Ramla Muhammad Sunusi, Usman Sharifi-Rad, Javad Quispe, Cristina Imran, Muhammad Rauf, Abdur Nadeem, Muhammad Gondal, Tanweer Aslam Ahmad, Bashir Genistein is an isoflavone first isolated from the brooming plant Dyer's Genista tinctoria L. and is widely distributed in the Fabaceae family. As an isoflavone, mammalian genistein exerts estrogen-like functions. Several biological effects of genistein have been reported in preclinical studies, such as the antioxidant, anti-inflammatory, antibacterial, and antiviral activities, the effects of angiogenesis and estrogen, and the pharmacological activities on diabetes and lipid metabolism. The purpose of this review is to provide up-to-date evidence of preclinical pharmacological activities with mechanisms of action, bioavailability, and clinical evidence of genistein. The literature was researched using the most important keyword “genistein” from the PubMed, Science, and Google Scholar databases, and the taxonomy was validated using The Plant List. Data were also collected from specialized books and other online resources. The main positive effects of genistein refer to the protection against cardiovascular diseases and to the decrease of the incidence of some types of cancer, especially breast cancer. Although the mechanism of protection against cancer involves several aspects of genistein metabolism, the researchers attribute this effect to the similarity between the structure of soy genistein and that of estrogen. This structural similarity allows genistein to displace estrogen from cellular receptors, thus blocking their hormonal activity. The pharmacological activities resulting from the experimental studies of this review support the traditional uses of genistein, but in the future, further investigations are needed on the efficacy, safety, and use of nanotechnologies to increase bioavailability and therapeutic efficacy. Wiley 2021-07-19 Article PeerReviewed Abdull Razis, Ahmad Faizal and Kamal, Ramla Muhammad and Sunusi, Usman and Sharifi-Rad, Javad and Quispe, Cristina and Imran, Muhammad and Rauf, Abdur and Nadeem, Muhammad and Gondal, Tanweer Aslam and Ahmad, Bashir (2021) Genistein: an integrative overview of its mode of action, pharmacological properties, and health benefits. Oxidative Medicine and Cellular Longevity, 2021 (Special Issue). pp. 1-36. ISSN 1942-0994; ESSN: 1942-0900 https://onlinelibrary.wiley.com/doi/10.1155/2021/3268136 10.1155/2021/3268136
institution	Universiti Putra Malaysia
building	UPM Library
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continent	Asia
country	Malaysia
content_provider	Universiti Putra Malaysia
content_source	UPM Institutional Repository
url_provider	http://psasir.upm.edu.my/
description	Genistein is an isoflavone first isolated from the brooming plant Dyer's Genista tinctoria L. and is widely distributed in the Fabaceae family. As an isoflavone, mammalian genistein exerts estrogen-like functions. Several biological effects of genistein have been reported in preclinical studies, such as the antioxidant, anti-inflammatory, antibacterial, and antiviral activities, the effects of angiogenesis and estrogen, and the pharmacological activities on diabetes and lipid metabolism. The purpose of this review is to provide up-to-date evidence of preclinical pharmacological activities with mechanisms of action, bioavailability, and clinical evidence of genistein. The literature was researched using the most important keyword “genistein” from the PubMed, Science, and Google Scholar databases, and the taxonomy was validated using The Plant List. Data were also collected from specialized books and other online resources. The main positive effects of genistein refer to the protection against cardiovascular diseases and to the decrease of the incidence of some types of cancer, especially breast cancer. Although the mechanism of protection against cancer involves several aspects of genistein metabolism, the researchers attribute this effect to the similarity between the structure of soy genistein and that of estrogen. This structural similarity allows genistein to displace estrogen from cellular receptors, thus blocking their hormonal activity. The pharmacological activities resulting from the experimental studies of this review support the traditional uses of genistein, but in the future, further investigations are needed on the efficacy, safety, and use of nanotechnologies to increase bioavailability and therapeutic efficacy.
format	Article
author	Abdull Razis, Ahmad Faizal Kamal, Ramla Muhammad Sunusi, Usman Sharifi-Rad, Javad Quispe, Cristina Imran, Muhammad Rauf, Abdur Nadeem, Muhammad Gondal, Tanweer Aslam Ahmad, Bashir
spellingShingle	Abdull Razis, Ahmad Faizal Kamal, Ramla Muhammad Sunusi, Usman Sharifi-Rad, Javad Quispe, Cristina Imran, Muhammad Rauf, Abdur Nadeem, Muhammad Gondal, Tanweer Aslam Ahmad, Bashir Genistein: an integrative overview of its mode of action, pharmacological properties, and health benefits
author_facet	Abdull Razis, Ahmad Faizal Kamal, Ramla Muhammad Sunusi, Usman Sharifi-Rad, Javad Quispe, Cristina Imran, Muhammad Rauf, Abdur Nadeem, Muhammad Gondal, Tanweer Aslam Ahmad, Bashir
author_sort	Abdull Razis, Ahmad Faizal
title	Genistein: an integrative overview of its mode of action, pharmacological properties, and health benefits
title_short	Genistein: an integrative overview of its mode of action, pharmacological properties, and health benefits
title_full	Genistein: an integrative overview of its mode of action, pharmacological properties, and health benefits
title_fullStr	Genistein: an integrative overview of its mode of action, pharmacological properties, and health benefits
title_full_unstemmed	Genistein: an integrative overview of its mode of action, pharmacological properties, and health benefits
title_sort	genistein: an integrative overview of its mode of action, pharmacological properties, and health benefits
publisher	Wiley
publishDate	2021
url	http://psasir.upm.edu.my/id/eprint/97437/ https://onlinelibrary.wiley.com/doi/10.1155/2021/3268136
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score	13.211869

Genistein: an integrative overview of its mode of action, pharmacological properties, and health benefits

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