Cover Image

'Energy-Dense, High-SFA and low-fiber’ dietary pattern lowered Adiponectin but not leptin concentration of breast cancer survivors

Dietary pattern (DP) and its relationship with disease biomarkers have received recognition in nutritional epidemiology investigations. However, DP relationships with adipokines (i.e., adiponectin and leptin) among breast cancer survivors remain unclear. Therefore, we assessed relationships between...

Full description

Saved in:
Bibliographic Details
Main Authors: Shahril, Mohd Razif, Zakarai, Nor Syamimi, Appannah, Geeta, Nurnazahiah, Ali, Jan Mohamed, Hamid Jan, Ahmad, Aryati, Pei, Lin Lua, Fenech, Michael
Format: Article
Language:English
Published: Multidisciplinary Digital Publishing Institute 2021
Online Access:http://psasir.upm.edu.my/id/eprint/97076/1/ABSTRACT.pdf
http://psasir.upm.edu.my/id/eprint/97076/
https://www.mdpi.com/2072-6643/13/10/3339
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.upm.eprints.97076
record_format eprints
spelling my.upm.eprints.970762022-10-17T02:05:51Z http://psasir.upm.edu.my/id/eprint/97076/ 'Energy-Dense, High-SFA and low-fiber’ dietary pattern lowered Adiponectin but not leptin concentration of breast cancer survivors Shahril, Mohd Razif Zakarai, Nor Syamimi Appannah, Geeta Nurnazahiah, Ali Jan Mohamed, Hamid Jan Ahmad, Aryati Pei, Lin Lua Fenech, Michael Dietary pattern (DP) and its relationship with disease biomarkers have received recognition in nutritional epidemiology investigations. However, DP relationships with adipokines (i.e., adiponectin and leptin) among breast cancer survivors remain unclear. Therefore, we assessed relationships between DP and high-molecular weight (HMW) adiponectin and leptin concentration among breast cancer survivors. This cross-sectional study involved 128 breast cancer survivors who attended the oncology outpatient clinic at two main government hospitals in the East Coast of Peninsular Malaysia. The serum concentration of HMW adiponectin and leptin were measured using enzyme-linked immunosorbent assay (ELISA) kits. A reduced rank regression method was used to analyze DP. Relationships between DP with HMW adiponectin and leptin were examined using regression models. The findings show that with every 1-unit increase in the ‘energy-dense, high-SFA, low-fiber’ DP z-score, there was a reduction by 0.41 μg/mL in HMW adiponectin which was independent of age, BMI, education level, occupation status, cancer stage, and duration since diagnosis. A similar relationship with leptin concentration was not observed. In conclusion, the ‘energy-dense, high-saturated fat and low-fiber’ DP, which is characterized by high intake levels of sugar-sweetened drinks and fat-based spreads but low intake of fruits and vegetables, is an unhealthy dietary pattern and unfavorable for HMW adiponectin concentration, but not for leptin. These findings could serve as a basis in developing specific preventive strategies that are tailored to the growing population of breast cancer survivors. Multidisciplinary Digital Publishing Institute 2021 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/97076/1/ABSTRACT.pdf Shahril, Mohd Razif and Zakarai, Nor Syamimi and Appannah, Geeta and Nurnazahiah, Ali and Jan Mohamed, Hamid Jan and Ahmad, Aryati and Pei, Lin Lua and Fenech, Michael (2021) 'Energy-Dense, High-SFA and low-fiber’ dietary pattern lowered Adiponectin but not leptin concentration of breast cancer survivors. Nutrients, 13 (10). art. no. 3339. pp. 1-12. ISSN 2072-6643 https://www.mdpi.com/2072-6643/13/10/3339 10.3390/nu13103339
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Dietary pattern (DP) and its relationship with disease biomarkers have received recognition in nutritional epidemiology investigations. However, DP relationships with adipokines (i.e., adiponectin and leptin) among breast cancer survivors remain unclear. Therefore, we assessed relationships between DP and high-molecular weight (HMW) adiponectin and leptin concentration among breast cancer survivors. This cross-sectional study involved 128 breast cancer survivors who attended the oncology outpatient clinic at two main government hospitals in the East Coast of Peninsular Malaysia. The serum concentration of HMW adiponectin and leptin were measured using enzyme-linked immunosorbent assay (ELISA) kits. A reduced rank regression method was used to analyze DP. Relationships between DP with HMW adiponectin and leptin were examined using regression models. The findings show that with every 1-unit increase in the ‘energy-dense, high-SFA, low-fiber’ DP z-score, there was a reduction by 0.41 μg/mL in HMW adiponectin which was independent of age, BMI, education level, occupation status, cancer stage, and duration since diagnosis. A similar relationship with leptin concentration was not observed. In conclusion, the ‘energy-dense, high-saturated fat and low-fiber’ DP, which is characterized by high intake levels of sugar-sweetened drinks and fat-based spreads but low intake of fruits and vegetables, is an unhealthy dietary pattern and unfavorable for HMW adiponectin concentration, but not for leptin. These findings could serve as a basis in developing specific preventive strategies that are tailored to the growing population of breast cancer survivors.
format Article
author Shahril, Mohd Razif
Zakarai, Nor Syamimi
Appannah, Geeta
Nurnazahiah, Ali
Jan Mohamed, Hamid Jan
Ahmad, Aryati
Pei, Lin Lua
Fenech, Michael
spellingShingle Shahril, Mohd Razif
Zakarai, Nor Syamimi
Appannah, Geeta
Nurnazahiah, Ali
Jan Mohamed, Hamid Jan
Ahmad, Aryati
Pei, Lin Lua
Fenech, Michael
'Energy-Dense, High-SFA and low-fiber’ dietary pattern lowered Adiponectin but not leptin concentration of breast cancer survivors
author_facet Shahril, Mohd Razif
Zakarai, Nor Syamimi
Appannah, Geeta
Nurnazahiah, Ali
Jan Mohamed, Hamid Jan
Ahmad, Aryati
Pei, Lin Lua
Fenech, Michael
author_sort Shahril, Mohd Razif
title 'Energy-Dense, High-SFA and low-fiber’ dietary pattern lowered Adiponectin but not leptin concentration of breast cancer survivors
title_short 'Energy-Dense, High-SFA and low-fiber’ dietary pattern lowered Adiponectin but not leptin concentration of breast cancer survivors
title_full 'Energy-Dense, High-SFA and low-fiber’ dietary pattern lowered Adiponectin but not leptin concentration of breast cancer survivors
title_fullStr 'Energy-Dense, High-SFA and low-fiber’ dietary pattern lowered Adiponectin but not leptin concentration of breast cancer survivors
title_full_unstemmed 'Energy-Dense, High-SFA and low-fiber’ dietary pattern lowered Adiponectin but not leptin concentration of breast cancer survivors
title_sort 'energy-dense, high-sfa and low-fiber’ dietary pattern lowered adiponectin but not leptin concentration of breast cancer survivors
publisher Multidisciplinary Digital Publishing Institute
publishDate 2021
url http://psasir.upm.edu.my/id/eprint/97076/1/ABSTRACT.pdf
http://psasir.upm.edu.my/id/eprint/97076/
https://www.mdpi.com/2072-6643/13/10/3339
_version_ 1748704640865665024
score 13.211869

Similar Items