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Electrochemical detection of diclofenac and dibucaine in synthetic saliva using liquid|liquid micro-interface modified by silicon nitride

In this study, electrochemical characterization and detection of an anti-inflammatory drug diclofenac (DCF) and a local anesthetic drug dibucaine (DIC) at synthetic saliva|1,6- dichlorohexane interface were carried out for the first time using cyclic voltammetry (CV) and differential pulse voltammet...

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Main Authors: Mohamed Almbrok, Eissa, Yusof, Nor Azah, Abdullah, Jaafar, Mohd Zawawi, Ruzniza
Format: Article
Published: ESG 2021
Online Access:http://psasir.upm.edu.my/id/eprint/97052/
http://www.electrochemsci.org/list21.htm
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spelling my.upm.eprints.970522023-04-19T04:07:08Z http://psasir.upm.edu.my/id/eprint/97052/ Electrochemical detection of diclofenac and dibucaine in synthetic saliva using liquid|liquid micro-interface modified by silicon nitride Mohamed Almbrok, Eissa Yusof, Nor Azah Abdullah, Jaafar Mohd Zawawi, Ruzniza In this study, electrochemical characterization and detection of an anti-inflammatory drug diclofenac (DCF) and a local anesthetic drug dibucaine (DIC) at synthetic saliva|1,6- dichlorohexane interface were carried out for the first time using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Although the CV of synthetic saliva matrix slightly decreased the available potential window at the micro-ITIES, it has no significant effect on the ion-transfer voltammetry of DCF and DIC at liquid|liquid interface. Peak currents response by DPV were linearly increased with both DCF and DIC concentrations in the synthetic saliva matrix over the concentrations ranged 8–40 μmol L-1 and 8–24 μmol L-1, and the calculated detection limits were 1.8 ± 0.2 μmol L-1 and 1.5 ± 0.14 μmol L-1, respectively. These results demonstrated that DPV at liquid|liquid micro interfaces arrays is a feasible analytical method for ionizable drugs detection in biomimetic matrixes. ESG 2021 Article PeerReviewed Mohamed Almbrok, Eissa and Yusof, Nor Azah and Abdullah, Jaafar and Mohd Zawawi, Ruzniza (2021) Electrochemical detection of diclofenac and dibucaine in synthetic saliva using liquid|liquid micro-interface modified by silicon nitride. International Journal of Electrochemical Science, 16. pp. 1-11. ISSN 1452-3981 http://www.electrochemsci.org/list21.htm 10.20964/2021.12.54
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description In this study, electrochemical characterization and detection of an anti-inflammatory drug diclofenac (DCF) and a local anesthetic drug dibucaine (DIC) at synthetic saliva|1,6- dichlorohexane interface were carried out for the first time using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Although the CV of synthetic saliva matrix slightly decreased the available potential window at the micro-ITIES, it has no significant effect on the ion-transfer voltammetry of DCF and DIC at liquid|liquid interface. Peak currents response by DPV were linearly increased with both DCF and DIC concentrations in the synthetic saliva matrix over the concentrations ranged 8–40 μmol L-1 and 8–24 μmol L-1, and the calculated detection limits were 1.8 ± 0.2 μmol L-1 and 1.5 ± 0.14 μmol L-1, respectively. These results demonstrated that DPV at liquid|liquid micro interfaces arrays is a feasible analytical method for ionizable drugs detection in biomimetic matrixes.
format Article
author Mohamed Almbrok, Eissa
Yusof, Nor Azah
Abdullah, Jaafar
Mohd Zawawi, Ruzniza
spellingShingle Mohamed Almbrok, Eissa
Yusof, Nor Azah
Abdullah, Jaafar
Mohd Zawawi, Ruzniza
Electrochemical detection of diclofenac and dibucaine in synthetic saliva using liquid|liquid micro-interface modified by silicon nitride
author_facet Mohamed Almbrok, Eissa
Yusof, Nor Azah
Abdullah, Jaafar
Mohd Zawawi, Ruzniza
author_sort Mohamed Almbrok, Eissa
title Electrochemical detection of diclofenac and dibucaine in synthetic saliva using liquid|liquid micro-interface modified by silicon nitride
title_short Electrochemical detection of diclofenac and dibucaine in synthetic saliva using liquid|liquid micro-interface modified by silicon nitride
title_full Electrochemical detection of diclofenac and dibucaine in synthetic saliva using liquid|liquid micro-interface modified by silicon nitride
title_fullStr Electrochemical detection of diclofenac and dibucaine in synthetic saliva using liquid|liquid micro-interface modified by silicon nitride
title_full_unstemmed Electrochemical detection of diclofenac and dibucaine in synthetic saliva using liquid|liquid micro-interface modified by silicon nitride
title_sort electrochemical detection of diclofenac and dibucaine in synthetic saliva using liquid|liquid micro-interface modified by silicon nitride
publisher ESG
publishDate 2021
url http://psasir.upm.edu.my/id/eprint/97052/
http://www.electrochemsci.org/list21.htm
_version_ 1765298663093960704
score 13.211869

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