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Efficacy of feed-based formalin-killed vaccine of Streptococcus iniae stimulates the gut-associated lymphoid tissues and immune response of red hybrid tilapia

Red hybrid tilapia were fed a formalin-killed oral Streptococcus iniae vaccine (FKV) in the present study was assessed. Three hundred Red hybrid tilapia 80 ± 10 g were divided into five groups (1A, 1B, 2A, 2B, and Cx), each consisting of 60 fish. Fish from Groups 1A, 1B, 2A, and 2B were fed with FKV...

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Main Authors: Hayat, Mohammad, Mohd Yusoff, Md Sabri, Samad, Mohd Jamil, Abdul Razak, Intan Shameha, Md Yasin, Ina Salwany, Thompson, Kim D., Hasni, Khalil
Format: Article
Language:English
Published: Multidisciplinary Digital Publishing Institute 2021
Online Access:http://psasir.upm.edu.my/id/eprint/97025/1/ABSTRACT.pdf
http://psasir.upm.edu.my/id/eprint/97025/
https://www.mdpi.com/2076-393X/9/1/51
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spelling my.upm.eprints.970252022-10-17T09:11:29Z http://psasir.upm.edu.my/id/eprint/97025/ Efficacy of feed-based formalin-killed vaccine of Streptococcus iniae stimulates the gut-associated lymphoid tissues and immune response of red hybrid tilapia Hayat, Mohammad Mohd Yusoff, Md Sabri Samad, Mohd Jamil Abdul Razak, Intan Shameha Md Yasin, Ina Salwany Thompson, Kim D. Hasni, Khalil Red hybrid tilapia were fed a formalin-killed oral Streptococcus iniae vaccine (FKV) in the present study was assessed. Three hundred Red hybrid tilapia 80 ± 10 g were divided into five groups (1A, 1B, 2A, 2B, and Cx), each consisting of 60 fish. Fish from Groups 1A, 1B, 2A, and 2B were fed with FKV over different periods of administration, while Group 2B was the only group of fish to receive an oral booster vaccination on day 14- and 21-days post-vaccination (dpv). Group Cx was fed with normal pellets containing no vaccine as a control group. At four weeks post-vaccination (wpv), all fish were experimentally infected with S. iniae. Groups 2A and 2B had the lowest level of mortalities following vaccination (45% and 30%, respectively) compared to Groups 1A and 1B (80% and 55%, respectively), while the level of mortalities in Group Cx was 100%. All vaccinated groups showed a significant increase in anti-S. iniae IgM levels (p < 0.05) in serum, mucus, and gut-lavage, while Group Cx did not (p > 0.05) and all fish in this group died by five weeks post-infection. In conclusion, fish fed with the S. iniae FKV had a greater level of protection against S. iniae, with increased specific antibody response to the vaccine and there was also evidence of GALT stimulation by the vaccine. Multidisciplinary Digital Publishing Institute 2021 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/97025/1/ABSTRACT.pdf Hayat, Mohammad and Mohd Yusoff, Md Sabri and Samad, Mohd Jamil and Abdul Razak, Intan Shameha and Md Yasin, Ina Salwany and Thompson, Kim D. and Hasni, Khalil (2021) Efficacy of feed-based formalin-killed vaccine of Streptococcus iniae stimulates the gut-associated lymphoid tissues and immune response of red hybrid tilapia. Vaccines, 9 (1). pp. 1-17. ISSN 2076-393X https://www.mdpi.com/2076-393X/9/1/51 10.3390/vaccines9010051
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Red hybrid tilapia were fed a formalin-killed oral Streptococcus iniae vaccine (FKV) in the present study was assessed. Three hundred Red hybrid tilapia 80 ± 10 g were divided into five groups (1A, 1B, 2A, 2B, and Cx), each consisting of 60 fish. Fish from Groups 1A, 1B, 2A, and 2B were fed with FKV over different periods of administration, while Group 2B was the only group of fish to receive an oral booster vaccination on day 14- and 21-days post-vaccination (dpv). Group Cx was fed with normal pellets containing no vaccine as a control group. At four weeks post-vaccination (wpv), all fish were experimentally infected with S. iniae. Groups 2A and 2B had the lowest level of mortalities following vaccination (45% and 30%, respectively) compared to Groups 1A and 1B (80% and 55%, respectively), while the level of mortalities in Group Cx was 100%. All vaccinated groups showed a significant increase in anti-S. iniae IgM levels (p < 0.05) in serum, mucus, and gut-lavage, while Group Cx did not (p > 0.05) and all fish in this group died by five weeks post-infection. In conclusion, fish fed with the S. iniae FKV had a greater level of protection against S. iniae, with increased specific antibody response to the vaccine and there was also evidence of GALT stimulation by the vaccine.
format Article
author Hayat, Mohammad
Mohd Yusoff, Md Sabri
Samad, Mohd Jamil
Abdul Razak, Intan Shameha
Md Yasin, Ina Salwany
Thompson, Kim D.
Hasni, Khalil
spellingShingle Hayat, Mohammad
Mohd Yusoff, Md Sabri
Samad, Mohd Jamil
Abdul Razak, Intan Shameha
Md Yasin, Ina Salwany
Thompson, Kim D.
Hasni, Khalil
Efficacy of feed-based formalin-killed vaccine of Streptococcus iniae stimulates the gut-associated lymphoid tissues and immune response of red hybrid tilapia
author_facet Hayat, Mohammad
Mohd Yusoff, Md Sabri
Samad, Mohd Jamil
Abdul Razak, Intan Shameha
Md Yasin, Ina Salwany
Thompson, Kim D.
Hasni, Khalil
author_sort Hayat, Mohammad
title Efficacy of feed-based formalin-killed vaccine of Streptococcus iniae stimulates the gut-associated lymphoid tissues and immune response of red hybrid tilapia
title_short Efficacy of feed-based formalin-killed vaccine of Streptococcus iniae stimulates the gut-associated lymphoid tissues and immune response of red hybrid tilapia
title_full Efficacy of feed-based formalin-killed vaccine of Streptococcus iniae stimulates the gut-associated lymphoid tissues and immune response of red hybrid tilapia
title_fullStr Efficacy of feed-based formalin-killed vaccine of Streptococcus iniae stimulates the gut-associated lymphoid tissues and immune response of red hybrid tilapia
title_full_unstemmed Efficacy of feed-based formalin-killed vaccine of Streptococcus iniae stimulates the gut-associated lymphoid tissues and immune response of red hybrid tilapia
title_sort efficacy of feed-based formalin-killed vaccine of streptococcus iniae stimulates the gut-associated lymphoid tissues and immune response of red hybrid tilapia
publisher Multidisciplinary Digital Publishing Institute
publishDate 2021
url http://psasir.upm.edu.my/id/eprint/97025/1/ABSTRACT.pdf
http://psasir.upm.edu.my/id/eprint/97025/
https://www.mdpi.com/2076-393X/9/1/51
_version_ 1748704636162801664
score 13.211869

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