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Dentinogenic ghost cell tumor in a Sumatran Rhinoceros

An adult female Sumatran rhinoceros was observed with a swelling in the left infraorbital region in March 2017. The swelling rapidly grew into a mass. A radiograph revealed a cystic radiolucent area in the left maxilla. In June 2017, the rhinoceros was euthanized. At necropsy, the infraorbital mass...

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Main Authors: Salleh, Annas, Zainuddin, Zainal Zahari, Mohamed Tarmizi, Mohamed Reza, Yap, Chee K., Chian, Ren Jeng, Saad, Mohd Zamri
Format: Article
Language:English
Published: Multidisciplinary Digital Publishing Institute 2021
Online Access:http://psasir.upm.edu.my/id/eprint/96616/1/ABSTRACT.pdf
http://psasir.upm.edu.my/id/eprint/96616/
https://www.mdpi.com/2076-2615/11/4/1173
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spelling my.upm.eprints.966162023-01-11T07:00:50Z http://psasir.upm.edu.my/id/eprint/96616/ Dentinogenic ghost cell tumor in a Sumatran Rhinoceros Salleh, Annas Zainuddin, Zainal Zahari Mohamed Tarmizi, Mohamed Reza Yap, Chee K. Chian, Ren Jeng Saad, Mohd Zamri An adult female Sumatran rhinoceros was observed with a swelling in the left infraorbital region in March 2017. The swelling rapidly grew into a mass. A radiograph revealed a cystic radiolucent area in the left maxilla. In June 2017, the rhinoceros was euthanized. At necropsy, the infraorbital mass measured 21 cm × 30 cm. Samples of the infraorbital mass, left parotid gland, and left masseter muscle were collected for histopathology (Hematoxylin & Eosin, Von Kossa, Masson’s trichrome, cytokeratin AE1/AE3, EMA, p53, and S-100). Numerous neoplastic epithelial cells showing pleomorphism and infiltration were observed. Islands of dentinoid material containing ghost cells and keratin pearls were observed with the aid of the two special histochemistry stains. Mitotic figures were rarely observed. All the neoplastic odontogenic cells and keratin pearls showed an intense positive stain for cytokeratin AE1/AE3, while some keratin pearls showed mild positive stains for S-100. All samples were negative for p53 and S-100 immunodetection. The mass was diagnosed as a dentinogenic ghost cell tumor. Multidisciplinary Digital Publishing Institute 2021 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/96616/1/ABSTRACT.pdf Salleh, Annas and Zainuddin, Zainal Zahari and Mohamed Tarmizi, Mohamed Reza and Yap, Chee K. and Chian, Ren Jeng and Saad, Mohd Zamri (2021) Dentinogenic ghost cell tumor in a Sumatran Rhinoceros. Animals, 11 (4). pp. 1-8. ISSN 2076-2615 https://www.mdpi.com/2076-2615/11/4/1173 10.3390/ani11041173
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description An adult female Sumatran rhinoceros was observed with a swelling in the left infraorbital region in March 2017. The swelling rapidly grew into a mass. A radiograph revealed a cystic radiolucent area in the left maxilla. In June 2017, the rhinoceros was euthanized. At necropsy, the infraorbital mass measured 21 cm × 30 cm. Samples of the infraorbital mass, left parotid gland, and left masseter muscle were collected for histopathology (Hematoxylin & Eosin, Von Kossa, Masson’s trichrome, cytokeratin AE1/AE3, EMA, p53, and S-100). Numerous neoplastic epithelial cells showing pleomorphism and infiltration were observed. Islands of dentinoid material containing ghost cells and keratin pearls were observed with the aid of the two special histochemistry stains. Mitotic figures were rarely observed. All the neoplastic odontogenic cells and keratin pearls showed an intense positive stain for cytokeratin AE1/AE3, while some keratin pearls showed mild positive stains for S-100. All samples were negative for p53 and S-100 immunodetection. The mass was diagnosed as a dentinogenic ghost cell tumor.
format Article
author Salleh, Annas
Zainuddin, Zainal Zahari
Mohamed Tarmizi, Mohamed Reza
Yap, Chee K.
Chian, Ren Jeng
Saad, Mohd Zamri
spellingShingle Salleh, Annas
Zainuddin, Zainal Zahari
Mohamed Tarmizi, Mohamed Reza
Yap, Chee K.
Chian, Ren Jeng
Saad, Mohd Zamri
Dentinogenic ghost cell tumor in a Sumatran Rhinoceros
author_facet Salleh, Annas
Zainuddin, Zainal Zahari
Mohamed Tarmizi, Mohamed Reza
Yap, Chee K.
Chian, Ren Jeng
Saad, Mohd Zamri
author_sort Salleh, Annas
title Dentinogenic ghost cell tumor in a Sumatran Rhinoceros
title_short Dentinogenic ghost cell tumor in a Sumatran Rhinoceros
title_full Dentinogenic ghost cell tumor in a Sumatran Rhinoceros
title_fullStr Dentinogenic ghost cell tumor in a Sumatran Rhinoceros
title_full_unstemmed Dentinogenic ghost cell tumor in a Sumatran Rhinoceros
title_sort dentinogenic ghost cell tumor in a sumatran rhinoceros
publisher Multidisciplinary Digital Publishing Institute
publishDate 2021
url http://psasir.upm.edu.my/id/eprint/96616/1/ABSTRACT.pdf
http://psasir.upm.edu.my/id/eprint/96616/
https://www.mdpi.com/2076-2615/11/4/1173
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score 13.211869

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